日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Preclinical characterization of the Toll-like receptor 7/8 antagonist MHV370 for lupus therapy

用于狼疮治疗的 Toll 样受体 7/8 拮抗剂 MHV370 的临床前特性研究

Stuart Hawtin ,Cédric André ,Géraldine Collignon-Zipfel ,Simone Appenzeller ,Bettina Bannert ,Lea Baumgartner ,Damian Beck ,Claudia Betschart ,Thomas Boulay ,Hermine I Brunner ,Melanie Ceci ,Jonathan Deane ,Roland Feifel ,Enrico Ferrero ,Diego Kyburz ,Frederique Lafossas ,Pius Loetscher ,Christina Merz-Stoeckle ,Pierre Michellys ,Barbara Nuesslein-Hildesheim ,Friedrich Raulf ,James S Rush ,Giulia Ruzzante ,Thomas Stein ,Samantha Zaharevitz ,Grazyna Wieczorek ,Richard Siegel ,Peter Gergely ,Tamas Shisha ,Tobias Junt

Low-molecular weight inhibitors of the alternative complement pathway

低分子量替代补体途径抑制剂

Schubart, Anna; Flohr, Stefanie; Junt, Tobias; Eder, Jörg

First-in-Human Study of the Safety, Pharmacokinetics, and Pharmacodynamics of MHV370, a Dual Inhibitor of Toll-Like Receptors 7 and 8, in Healthy Adults

MHV370(一种 Toll 样受体 7 和 8 的双重抑制剂)在健康成年人中的安全性、药代动力学和药效学的首次人体研究

Shisha, Tamas; Posch, Maximilian G; Lehmann, Jeanette; Feifel, Roland; Junt, Tobias; Hawtin, Stuart; Schuemann, Jens; Avrameas, Alexandre; Danekula, Rambabu; Misiolek, Patrycja; Siegel, Richard; Gergely, Peter

Distinct pathogenic roles for resident and monocyte-derived macrophages in lupus nephritis

狼疮性肾炎中驻留巨噬细胞和单核细胞衍生巨噬细胞的不同致病作用

Nathan Richoz, Zewen K Tuong, Kevin W Loudon, Eduardo Patiño-Martínez, John R Ferdinand, Anaïs Portet, Kathleen R Bashant, Emeline Thevenon, Francesca Rucci, Thomas Hoyler, Tobias Junt, Mariana J Kaplan, Richard M Siegel, Menna R Clatworthy

Unbiased screen for pathogens in human paraffin-embedded tissue samples by whole genome sequencing and metagenomics

利用全基因组测序和宏基因组学对人类石蜡包埋组织样本中的病原体进行无偏筛查

Nienhold, Ronny; Mensah, Nadine; Frank, Angela; Graber, Anne; Koike, Jacqueline; Schwab, Nathalie; Hernach, Claudia; Zsikla, Veronika; Willi, Niels; Cathomas, Gieri; Hamelin, Baptiste; Graf, Susanne; Junt, Tobias; Mertz, Kirsten D

Structure-Based Optimization of a Fragment-like TLR8 Binding Screening Hit to an In Vivo Efficacious TLR7/8 Antagonist

基于结构的TLR8结合筛选先导化合物结构优化,得到体内有效的TLR7/8拮抗剂

Betschart, Claudia; Faller, Michael; Zink, Florence; Hemmig, René; Blank, Jutta; Vangrevelinghe, Eric; Bourrel, Marjorie; Glatthar, Ralf; Behnke, Dirk; Barker, Kerstin; Heizmann, Andreas; Angst, Daniela; Nimsgern, Pierre; Jacquier, Sébastien; Junt, Tobias; Zipfel, Géraldine; Ruzzante, Giulia; Loetscher, Pius; Limonta, Sarah; Hawtin, Stuart; Andre, Cedric Bernard; Boulay, Thomas; Feifel, Roland; Knoepfel, Thomas

COVID-19 Autopsies Reveal Underreporting of SARS-CoV-2 Infection and Scarcity of Co-infections

新冠肺炎尸检结果显示,SARS-CoV-2感染病例被低估,合并感染病例也很少见。

Schwab, Nathalie; Nienhold, Ronny; Henkel, Maurice; Baschong, Albert; Graber, Anne; Frank, Angela; Mensah, Nadine; Koike, Jacqueline; Hernach, Claudia; Sachs, Melanie; Daun, Till; Zsikla, Veronika; Willi, Niels; Junt, Tobias; Mertz, Kirsten D

Butyrate inhibits human mast cell activation via epigenetic regulation of FcεRI-mediated signaling

丁酸通过表观遗传调控 FcεRI 介导的信号抑制人类肥大细胞活化

Jelle Folkerts, Frank Redegeld, Gert Folkerts, Bart Blokhuis, Mariska P M van den Berg, Marjolein J W de Bruijn, Wilfred F J van IJcken, Tobias Junt, See-Ying Tam, Stephen J Galli, Rudi W Hendriks, Ralph Stadhouders, Marcus Maurer

Malt1 Protease Deficiency in Mice Disrupts Immune Homeostasis at Environmental Barriers and Drives Systemic T Cell-Mediated Autoimmunity

小鼠体内Malt1蛋白酶缺乏会破坏环境屏障处的免疫稳态,并引发系统性T细胞介导的自身免疫性疾病。

Kea Martin,Ratiba Touil,Yeter Kolb,Grozdan Cvijetic,Kiichi Murakami,Laura Israel,Fernanda Duraes,David Buffet,Anton Glück,Satoru Niwa,Marc Bigaud,Tobias Junt,Natasa Zamurovic,Philip Smith,Kathy D McCoy,Pamela S Ohashi,Frédéric Bornancin,Thomas Calzascia

GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis

GPR91 感知炎性巨噬细胞释放的细胞外琥珀酸并加剧类风湿性关节炎

Amanda Littlewood-Evans, Sophie Sarret, Verena Apfel, Perrine Loesle, Janet Dawson, Juan Zhang, Alban Muller, Bruno Tigani, Rainer Kneuer, Saijel Patel, Stephanie Valeaux, Nina Gommermann, Tina Rubic-Schneider, Tobias Junt, José M Carballido