Structure-Based Optimization of a Fragment-like TLR8 Binding Screening Hit to an In Vivo Efficacious TLR7/8 Antagonist
基于结构的TLR8结合筛选先导化合物结构优化,得到体内有效的TLR7/8拮抗剂
期刊:ACS Medicinal Chemistry Letters
影响因子:4
doi:10.1021/acsmedchemlett.1c00696
Betschart, Claudia; Faller, Michael; Zink, Florence; Hemmig, René; Blank, Jutta; Vangrevelinghe, Eric; Bourrel, Marjorie; Glatthar, Ralf; Behnke, Dirk; Barker, Kerstin; Heizmann, Andreas; Angst, Daniela; Nimsgern, Pierre; Jacquier, Sébastien; Junt, Tobias; Zipfel, Géraldine; Ruzzante, Giulia; Loetscher, Pius; Limonta, Sarah; Hawtin, Stuart; Andre, Cedric Bernard; Boulay, Thomas; Feifel, Roland; Knoepfel, Thomas