日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Acquired On-Target Alterations Drive Clinical Resistance to p53-Y220C Reactivators

获得的靶向改变导致对 p53-Y220C 激活剂的临床耐药性

Fece de la Cruz, Ferran; Varkaris, Andreas; Patel, Parasvi S; Kushner, Elijah W; Morales-Giron, Alvin A; Lee, Sangmi Sandra; Singh, Ankit; Kim, Clara T; Norden, Bryanna L; Ehnstrom, Sara; Riedl, Jakob M; Curtis, Jacquelyn M; Barnes, Haley; Kehlmann, Allison M; Chevalier, Nicholas J; Okuma, Hitomi S; Patel, Manisha; Wirth, Lori J; Connell, Brendan; Nugent, Francis; Pappas, Leontios; Lau, Kayao; Juric, Dejan; Hopkins, Jessica L; Guiley, Keelan Z; Shokat, Kevan M; Gulhan, Doga C; Parikh, Aparna R; Corcoran, Ryan B

PI3Kα Inhibitor and Degrader Inavolisib Can Co-opt FGFR2 to Enhance Responses in Patients with PIK3CA-Mutated Solid Tumors and in Preclinical Models.

PI3Kα抑制剂和降解剂Inavolisib可利用FGFR2增强PIK3CA突变实体瘤患者和临床前模型的疗效。

Juric Dejan, Song Kyung, Johnson Radia M, Accordino Melissa K, Bedard Philippe L, Cervantes Andrés, Gambardella Valentina, Hamilton Erika, Italiano Antoine, Kalinsky Kevin, Krop Ian E, Oliveira Mafalda, Saura Cristina, Schmid Peter, Turner Nicholas C, Varga Andreea, Gendreau Steven, Hwang Michael S, Kuang Zheng, Lau Jeffrey T, Lin Eva, Pham Trang, Maddalo Danilo, Rees Matthew G, Ronan Melissa M, Roth Jennifer A, Martin Scott, Sodir Nicole M, Sokol Ethan S, Whitfield Zachary J, Wong Alice, Yauch Robert L, Aimi Junko, Cheeti Sravanthi, Fredrickson Jill, Hilz Stephanie, Hafner Marc, Hutchinson Katherine E, Jin Yanling, Peters Ubong, Zingg Daniel, Royer-Joo Stephanie, Shankar Noopur, Schutzman Jennifer L, Jhaveri Komal L, Dey Anwesha

BH3 mimetics targeting BCL-XL have efficacy in solid tumors with RB1 loss and replication stress.

靶向 BCL-XL 的 BH3 模拟物对 RB1 缺失和复制压力的实体瘤有效

Varkaris Andreas, Wang Keshan, Nouri Mannan, Kozlova Nina, Schmidt Daniel R, Stavridi Anastasia, Arai Seiji, Ambrosio Nicholas, Poluben Larysa, Jimenez-Vacas Juan M, Westaby Daniel, Carmichael Juliet, Xie Fang, Figueiredo Ines, Buroni Lorenzo, Neeb Antje, Gurel Bora, Chevalier Nicholas, Brown Lisha, Voznesensky Olga, Chen Shao-Yong, Russo Joshua W, Yuan Xin, Juric Dejan, Beltran Himisha, De Bono Johann S, Vander Heiden Matthew G, Einstein David J, Muranen Taru, Corey Eva, Sharp Adam, Balk Steven P

Phase I dose-escalation and pharmacodynamic study of STING agonist E7766 in advanced solid tumors

STING激动剂E7766治疗晚期实体瘤的I期剂量递增和药效学研究

Luke, Jason J; Pinato, David J; Juric, Dejan; LoRusso, Patricia; Hosein, Peter J; Desai, Anupam M; Haddad, Robert; de Miguel, María; Cervantes, Andrés; Kim, Won Seog; Marabelle, Aurélien; Zhang, Yan; Rong, Yuanxin; Yuan, Xiaobin; Champiat, Stéphane

TOP1 Mutations and Cross-Resistance to Antibody-Drug Conjugates in Patients with Metastatic Breast Cancer.

转移性乳腺癌患者中TOP1突变和抗体药物偶联物的交叉耐药性

Abelman Rachel O, Wu Bogang, Barnes Haley, Medford Arielle, Norden Bryanna, Putur Annika, Bitman Elena, Thant Win, Liu Ting, Weipert Caroline, Fell Geoffrey, Spring Laura M, Wander Seth A, Moy Beverly, Vidula Neelima, Isakoff Steven J, Varkaris Andreas, Juric Dejan, Corcoran Ryan B, Ellisen Leif W, Bardia Aditya

Phase 1/2 study of H3B-6545 in women with locally advanced/metastatic estrogen receptor-positive, HER2-negative breast cancer

H3B-6545治疗局部晚期/转移性雌激素受体阳性、HER2阴性乳腺癌女性患者的I/II期研究

Hamilton, Erika; Pluard, Timothy; Wang, Judy S; Morikawa, Aki; Johnston, Stephen; Dees, E Claire; Vaklavas, Christos; Armstrong, Anne; Munster, Pamela; Unni, Nisha; Wright, Gail S; Kayali, Fadi; Song, Tingting; Rong, Yuanxin; Yamaguchi, Kohei; Juric, Dejan

Immune responses in checkpoint myocarditis across heart, blood and tumour.

检查点心肌炎在心脏、血液和肿瘤中的免疫反应。

Blum Steven M, Zlotoff Daniel A, Smith Neal P, Kernin Isabela J, Ramesh Swetha, Zubiri Leyre, Caplin Joshua, Samanta Nandini, Martin Sidney, Wang Mike, Tirard Alice, Song Yuhui, Xu Katherine H, Barth Jaimie, Sen Pritha, Slowikowski Kamil, Tantivit Jessica, Manakongtreecheep Kasidet, Arnold Benjamin Y, Nasrallah Mazen, Pinto Christopher J, McLoughlin Daniel, Jackson Monica, Chan PuiYee, Lawless Aleigha, Michaud William A, Sharova Tatyana, Nieman Linda T, Gainor Justin F, Wu Catherine J, Juric Dejan, Mino-Kenudson Mari, Oliveira Giacomo, Sullivan Ryan J, Boland Genevieve M, Stone James R, Thomas Molly F, Neilan Tomas G, Reynolds Kerry L, Villani Alexandra-Chloé

Datopotamab Deruxtecan in Advanced or Metastatic HR+/HER2- and Triple-Negative Breast Cancer: Results From the Phase I TROPION-PanTumor01 Study

Datopotamab Deruxtecan 治疗晚期或转移性 HR+/HER2- 和三阴性乳腺癌:来自 I 期 TROPION-PanTumor01 研究的结果

Bardia, Aditya; Krop, Ian E; Kogawa, Takahiro; Juric, Dejan; Tolcher, Anthony W; Hamilton, Erika P; Mukohara, Toru; Lisberg, Aaron; Shimizu, Toshio; Spira, Alexander I; Tsurutani, Junji; Damodaran, Senthil; Papadopoulos, Kyriakos P; Greenberg, Jonathan; Kobayashi, Fumiaki; Zebger-Gong, Hong; Wong, Rie; Kawasaki, Yui; Nakamura, Tadakatsu; Meric-Bernstam, Funda

Phase I/Ib Trial of Inavolisib Plus Palbociclib and Endocrine Therapy for PIK3CA-Mutated, Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Advanced or Metastatic Breast Cancer

Inavolisib联合Palbociclib和内分泌疗法治疗PIK3CA突变、激素受体阳性、人表皮生长因子受体2阴性晚期或转移性乳腺癌的I/Ib期临床试验

Jhaveri, Komal L; Accordino, Melissa K; Bedard, Philippe L; Cervantes, Andrés; Gambardella, Valentina; Hamilton, Erika; Italiano, Antoine; Kalinsky, Kevin; Krop, Ian E; Oliveira, Mafalda; Schmid, Peter; Saura, Cristina; Turner, Nicholas C; Varga, Andrea; Cheeti, Sravanthi; Hilz, Stephanie; Hutchinson, Katherine E; Jin, Yanling; Royer-Joo, Stephanie; Peters, Ubong; Shankar, Noopur; Schutzman, Jennifer L; Juric, Dejan

Phase I/II Study of Combined BCL-xL and MEK Inhibition with Navitoclax and Trametinib in KRAS or NRAS Mutant Advanced Solid Tumors

纳维托克和曲美替尼联合抑制BCL-xL和MEK治疗KRAS或NRAS突变晚期实体瘤的I/II期研究

Corcoran, Ryan B; Do, Khanh T; Kim, Jeong E; Cleary, James M; Parikh, Aparna R; Yeku, Oladapo O; Xiong, Niya; Weekes, Colin D; Veneris, Jennifer; Ahronian, Leanne G; Mauri, Gianluca; Tian, Jun; Norden, Bryanna L; Michel, Alexa G; Van Seventer, Emily E; Siravegna, Giulia; Camphausen, Kyle; Chi, Gary; Fetter, Isobel J; Brugge, Joan S; Chen, Helen; Takebe, Naoko; Penson, Richard T; Juric, Dejan; Flaherty, Keith T; Sullivan, Ryan J; Clark, Jeffrey W; Heist, Rebecca S; Matulonis, Ursula A; Liu, Joyce F; Shapiro, Geoffrey I