日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling

稳定 RAS:PDE6D 复合物是抑制 RAS 信号传导的新策略

Tamas Yelland, Esther Garcia, Charles Parry, Dominika Kowalczyk, Marta Wojnowska, Andrea Gohlke, Matja Zalar, Kenneth Cameron, Gillian Goodwin, Qing Yu, Peng-Cheng Zhu, Yasmin ElMaghloob, Angelo Pugliese, Lewis Archibald, Andrew Jamieson, Yong Xiang Chen, Duncan McArthur, Justin Bower, Shehab Ismail

The development of theory-informed participant-centred interventions to maximise participant retention in randomised controlled trials

制定以理论为指导、以参与者为中心的干预措施,以最大限度地提高随机对照试验中参与者的保留率

Newlands, Rumana; Duncan, Eilidh; Treweek, Shaun; Elliott, Jim; Presseau, Justin; Bower, Peter; MacLennan, Graeme; Ogden, Margaret; Wells, Mary; Witham, Miles D; Young, Bridget; Gillies, Katie

Re-introducing non-optimal synonymous codons into codon-optimized constructs enhances soluble recovery of recombinant proteins from Escherichia coli

将非最优同义密码子重新引入密码子优化的构建体中可增强大肠杆菌中重组蛋白的可溶性回收率

Jennifer Konczal, Justin Bower, Christopher H Gray

Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer

发现对皮肤癌具有治疗作用的强效选择性 MRCK 抑制剂

Mathieu Unbekandt, Simone Belshaw, Justin Bower, Maeve Clarke, Jacqueline Cordes, Diane Crighton, Daniel R Croft, Martin J Drysdale, Mathew J Garnett, Kathryn Gill, Christopher Gray, David A Greenhalgh, James A M Hall, Jennifer Konczal, Sergio Lilla, Duncan McArthur, Patricia McConnell, Laura McDona

A fully automated procedure for the parallel, multidimensional purification and nucleotide loading of the human GTPases KRas, Rac1 and RalB

用于人类 GTPases KRas、Rac1 和 RalB 的并行、多维纯化和核苷酸加载的全自动程序

Christopher H Gray, Jennifer Konczal, Mokdad Mezna, Shehab Ismail, Justin Bower, Martin Drysdale

Identification of a Selective G1-Phase Benzimidazolone Inhibitor by a Senescence-Targeted Virtual Screen Using Artificial Neural Networks

使用人工神经网络通过针对衰老的虚拟筛选鉴定选择性 G1 期苯并咪唑酮抑制剂

Alan E Bilsland, Angelo Pugliese, Yu Liu, John Revie, Sharon Burns, Carol McCormick, Claire J Cairney, Justin Bower, Martin Drysdale, Masashi Narita, Mahito Sadaie, W Nicol Keith

A novel small-molecule MRCK inhibitor blocks cancer cell invasion

新型小分子MRCK抑制剂可阻断癌细胞侵袭

Mathieu Unbekandt, Daniel R Croft, Diane Crighton, Mokdad Mezna, Duncan McArthur, Patricia McConnell, Alexander W Schüttelkopf, Simone Belshaw, Andrew Pannifer, Mairi Sime, Justin Bower, Martin Drysdale, Michael F Olson