文献库，生知库 | 链接生命科学的每一步

日期影响因子

Anti-vascular endothelial growth factor treatment potentiates immune checkpoint blockade through a BAFF- and IL-12-dependent reprogramming of the TME

抗血管内皮生长因子治疗通过BAFF和IL-12依赖的肿瘤微环境重编程增强免疫检查点阻断作用。

期刊:Immunity

影响因子:25.5

doi:10.1016/j.immuni.2025.02.017

Mohamed-Reda Benmebarek ，Cihan Oguz ，Matthias Seifert ，Benjamin Ruf ，Yuta Myojin ，Kylynda C Bauer ，Patrick Huang ，Chi Ma ，Marina Villamor-Payà ，Francisco Rodriguez-Matos ，Marlaine Soliman ，Rajiv Trehan ，Cecilia Monge ，Changqing Xie ，David E Kleiner ，Bradford J Wood ，Elliot B Levy ，Anuradha Budhu ，Noemi Kedei ，Christian T Mayer ，Xin Wei Wang ，Justin Lack ，William Telford ，Firouzeh Korangy ，Tim F Greten

肿瘤微环境

免疫/内分泌

发表日期：2025

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Genetic variation in IL-4 activated tissue resident macrophages determines strain-specific synergistic responses to LPS epigenetically

IL-4激活的组织驻留巨噬细胞的遗传变异决定了菌株特异性的LPS协同反应的表观遗传学特征。

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-025-56379-8

Mingming Zhao ,Dragana Jankovic ,Verena M Link ,Camila Oliveira Silva Souza ,Katherine M Hornick ,Oyebola Oyesola ,Yasmine Belkaid ,Justin Lack ,Png Loke

免疫/内分泌

细胞生物学

发表日期：2025

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Topical Steroid Withdrawal Is a Targetable Excess of Mitochondrial NAD

局部类固醇停药是线粒体NAD过量的可靶向治疗目标。

期刊:Journal of Investigative Dermatology

影响因子:5.7

doi:10.1016/j.jid.2024.11.026

Nadia Shobnam ，Grace Ratley ，Sarini Saksena ，Manoj Yadav ，Prem Prashant Chaudhary ，Ashleigh A Sun ，Katherine N Howe ，Manasi Gadkari ，Luis M Franco ，Sundar Ganesan ，Katelyn J McCann ，Amy P Hsu ，Kishore Kanakabandi ，Stacy Ricklefs ，Justin Lack ，Weiming Yu ，Morgan Similuk ，Magdalena A Walkiewicz ，Donna D Gardner ，Kelly Barta ，Kathryn Tullos ，Ian A Myles

发表日期：2025

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Immunologic Profiling of CSF in Subarachnoid Neurocysticercosis Reveals Specific Interleukin-10-Producing Cell Populations During Treatment

蛛网膜下腔神经囊虫病脑脊液免疫学分析揭示治疗期间特定的白细胞介素-10产生细胞群

期刊:Neurology-Neuroimmunology & Neuroinflammation

影响因子:7.8

doi:10.1212/NXI.0000000000200320

Nina L Tang ,Paul Schaughency ,Pedro Gazzinelli-Guimaraes ,Justin Lack ,Lauren Thumm ,Emily Miltenberger ,Theodore E Nash ,Thomas B Nutman ,Elise M O'Connell

细胞生物学

免疫/内分泌

发表日期：2024

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Mitochondrial Hyperactivity and Reactive Oxygen Species Drive Innate Immunity to the Yellow Fever Virus-17D Live-Attenuated Vaccine

线粒体过度活跃和活性氧驱动对黄热病毒 17D 减毒活疫苗的先天免疫

doi:10.1101/2024.09.04.611167

Samantha G Muccilli, Benjamin Schwarz, Forrest Jessop, Jeffrey G Shannon, Eric Bohrnsen, Byron Shue, Seon-Hui Hong, Thomas Hsu, Alison W Ashbrook, Joseph W Guarnieri, Justin Lack, Douglas C Wallace, Catharine M Bosio, Margaret R MacDonald, Charles M Rice, Jonathan W Yewdell, Sonja M Best

发表日期：2024

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Environmental sphagnum-associated fungi target thiol homeostasis to compete with Mycobacterium tuberculosis

环境泥炭藓相关真菌以硫醇稳态为目标与结核分枝杆菌竞争

doi:10.1101/2024.09.23.614403

Neha Malhotra, Sangmi Oh, Peter Finin, Jessica Medrano, Jenna Andrews, Michael Goodwin, Tovah E Markowitz, Justin Lack, Helena I M Boshoff, Clifton Earl Barry

发表日期：2024

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Genetic variation in IL-4 activated tissue resident macrophages alters the epigenetic state to determine strain specific synergistic responses to LPS

IL-4 激活的组织驻留巨噬细胞中的遗传变异会改变表观遗传状态，从而决定菌株对 LPS 的特定协同反应

doi:10.21203/rs.3.rs-3759654/v1

Mingming Zhao, Dragana Jankovic, Katherine M Hornick, Verena M Link, Camila Oliveira Silva Souza, Yasmine Belkaid, Justin Lack, P'ng Loke

细胞生物学

发表日期：2024

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Epithelial-intrinsic defects in TGFβR signaling drive local allergic inflammation manifesting as eosinophilic esophagitis

TGFβR信号通路上皮细胞内在缺陷驱动局部过敏性炎症，表现为嗜酸性食管炎。

期刊:Science Immunology

影响因子:17.6

doi:10.1126/sciimmunol.abp9940

Karen Laky ，Jessica L Kinard ，Jenny Min Li ，Ian N Moore ，Justin Lack ，Elizabeth R Fischer ，Juraj Kabat ，Rachel Latanich ，Nicholas C Zachos ，Ajinkya R Limkar ，Katherine A Weissler ，Robert W Thompson ，Thomas A Wynn ，Harry C Dietz ，Anthony L Guerrerio ，Pamela A Frischmeyer-Guerrerio

细胞生物学

发表日期：2023

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CRISPR/Cas9-engineering of HMC-1.2 cells renders a human mast cell line with a single D816V-KIT mutation: An improved preclinical model for research on mastocytosis

CRISPR/Cas9 改造 HMC-1.2 细胞，产生具有单个 D816V-KIT 突变的人类肥大细胞系：一种用于研究肥大细胞增多症的改进临床前模型

期刊:Frontiers in Immunology

影响因子:5.7

doi:10.3389/fimmu.2023.1078958

Geethani Bandara, Guido H Falduto, Andrea Luker, Yun Bai, Annika Pfeiffer, Justin Lack, Dean D Metcalfe, Ana Olivera

细胞生物学

发表日期：2023

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Germline- and Somatic-Inactivating FLCN Variants in Parathyroid Cancer and Atypical Parathyroid Tumors

甲状旁腺癌和非典型甲状旁腺肿瘤中的种系和体细胞失活 FLCN 变异

期刊:Journal of Clinical Endocrinology & Metabolism

doi:10.1210/clinem/dgad136

Smita Jha, James Welch, Rana Tora, Justin Lack, Andrew Warner, Jaydira Del Rivero, Samira M Sadowski, Naris Nilubol, Laura S Schmidt, W Marston Linehan, Lee S Weinstein, William F Simonds, Sunita K Agarwal

发表日期：2023

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