Justin Langerman相关文献与解析，生知库 | 链接生命科学的每一步

Shreya Udani # ,Justin Langerman # ,Doyeon Koo ,Sevana Baghdasarian ,Brian Cheng ,Simran Kang ,Citradewi Soemardy ,Joseph de Rutte ,Kathrin Plath ,Dino Di Carlo

细胞生物学

发表日期：2024

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Genetic Screen in a Preclinical Model of Sarcoma Development Defines Drivers and Therapeutic Vulnerabilities

在肉瘤发展的临床前模型中进行基因筛选，确定驱动因素和治疗弱点

期刊:Clinical Cancer Research

影响因子:10

doi:10.1158/1078-0432.CCR-24-1238

Jack Freeland # ，Maria Muñoz # ，Edmond O'Donnell 3rd ，Justin Langerman ，Morgan Darrow ，Jessica Bergonio ，Julissa Suarez-Navarro ，Steven Thorpe ，Robert Canter ，Robert Lor Randall ，Kathrin Plath ，Kermit L Carraway 3rd ，Owen N Witte ，Thomas G Graeber ，Janai R Carr-Ascher

发表日期：2024

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Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1 transcription factor in antitumor immunity

IRF1转录因子在抗肿瘤免疫中发挥着截然相反的肿瘤细胞内在和外在作用

期刊:Cell Reports

影响因子:7.5

doi:10.1016/j.celrep.2024.114289

Prabhat K Purbey ，Joowon Seo ，Manash K Paul ，Keisuke S Iwamoto ，Allison E Daly ，An-Chieh Feng ，Ameya S Champhekar ，Justin Langerman ，Katie M Campbell ，Dörthe Schaue ，William H McBride ，Steven M Dubinett ，Antoni Ribas ，Stephen T Smale ，Philip O Scumpia

H3K36 methylation maintains cell identity by regulating opposing lineage programmes

H3K36甲基化通过调控相反的谱系程序来维持细胞身份。

期刊:Nature Cell Biology

影响因子:17.3

doi:10.1038/s41556-023-01191-z

Michael S Hoetker ，Masaki Yagi ，Bruno Di Stefano ，Justin Langerman ，Simona Cristea ，Lai Ping Wong ，Aaron J Huebner ，Jocelyn Charlton ，Weixian Deng ，Chuck Haggerty ，Ruslan I Sadreyev ，Alexander Meissner ，Franziska Michor ，Kathrin Plath ，Konrad Hochedlinger

Secretion encoded single-cell sequencing (SEC-seq) uncovers gene expression signatures associated with high VEGF-A secretion in mesenchymal stromal cells

分泌编码单细胞测序 (SEC-seq) 揭示了与间充质基质细胞中高 VEGF-A 分泌相关的基因表达特征

期刊:

影响因子:

doi:10.1101/2023.01.07.523110

Shreya Udani, Justin Langerman, Doyeon Koo, Sevana Baghdasarian, Brian Cheng, Simran Kang, Citradewi Soemardy, Joseph de Rutte, Kathrin Plath, Dino Di Carlo

Oct4:Sox2 binding is essential for establishing but not maintaining active and silent states of dynamically regulated genes in pluripotent cells

Oct4：Sox2 结合对于多能细胞中动态调控基因的建立（但不维持）活跃和沉默状态至关重要

期刊:Genes & Development

影响因子:1.9

doi:10.1101/gad.350113.122

Jerry Hung-Hao Lo, Miguel Edwards, Justin Langerman, Rupa Sridharan, Kathrin Plath, Stephen T Smale

Transcriptional analysis of cystic fibrosis airways at single-cell resolution reveals altered epithelial cell states and composition

对囊性纤维化气道进行单细胞分辨率的转录组分析揭示了上皮细胞状态和组成的改变

期刊:Nature Medicine

影响因子:58.7

doi:10.1038/s41591-021-01332-7

Gianni Carraro # ，Justin Langerman # ，Shan Sabri ，Zareeb Lorenzana ，Arunima Purkayastha ，Guangzhu Zhang ，Bindu Konda ，Cody J Aros ，Ben A Calvert ，Aleks Szymaniak ，Emily Wilson ，Michael Mulligan ，Priyanka Bhatt ，Junjie Lu ，Preethi Vijayaraj ，Changfu Yao ，David W Shia ，Andrew J Lund ，Edo Israely ，Tammy M Rickabaugh ，Jason Ernst ，Martin Mense ，Scott H Randell ，Eszter K Vladar ，Amy L Ryan ，Kathrin Plath ，John E Mahoney ，Barry R Stripp ，Brigitte N Gomperts

SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition

SARS-CoV-2 感染会改变宿主细胞代谢，并且可能易受 mTORC1 抑制的影响

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-021-22166-4

Peter J Mullen, Gustavo Garcia Jr, Arunima Purkayastha, Nedas Matulionis, Ernst W Schmid, Milica Momcilovic, Chandani Sen, Justin Langerman, Arunachalam Ramaiah, David B Shackelford, Robert Damoiseaux, Samuel W French, Kathrin Plath, Brigitte N Gomperts, Vaithilingaraja Arumugaswami, Heather R Chris

Species-Specific Relationships between DNA and Chromatin Properties of CpG Islands in Embryonic Stem Cells and Differentiated Cells

胚胎干细胞和分化细胞中 CpG 岛 DNA 和染色质特性之间的物种特异性关系

期刊:Stem Cell Reports

影响因子:5.9

doi:10.1016/j.stemcr.2021.02.016

Justin Langerman, David Lopez, Matteo Pellegrini, Stephen T Smale

Direct Exposure to SARS-CoV-2 and Cigarette Smoke Increases Infection Severity and Alters the Stem Cell-Derived Airway Repair Response

直接接触SARS-CoV-2病毒和香烟烟雾会加重感染严重程度并改变干细胞衍生的气道修复反应。

期刊:Cell Stem Cell

影响因子:19.8

doi:10.1016/j.stem.2020.11.010

Arunima Purkayastha ,Chandani Sen ,Gustavo Garcia Jr ,Justin Langerman ,David W Shia ,Luisa K Meneses ,Preethi Vijayaraj ,Abdo Durra ,Caroline R Koloff ,Delilah R Freund ,Justin Chi ,Tammy M Rickabaugh ,Apoorva Mulay ,Bindu Konda ,Myung S Sim ,Barry R Stripp ,Kathrin Plath ,Vaithilingaraja Arumugaswami ,Brigitte N Gomperts

Associating growth factor secretions and transcriptomes of single cells in nanovials using SEC-seq

利用SEC-seq技术将纳米管中单个细胞的生长因子分泌和转录组关联起来

Genetic Screen in a Preclinical Model of Sarcoma Development Defines Drivers and Therapeutic Vulnerabilities

在肉瘤发展的临床前模型中进行基因筛选，确定驱动因素和治疗弱点

Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1 transcription factor in antitumor immunity

IRF1转录因子在抗肿瘤免疫中发挥着截然相反的肿瘤细胞内在和外在作用

H3K36 methylation maintains cell identity by regulating opposing lineage programmes

H3K36甲基化通过调控相反的谱系程序来维持细胞身份。

Secretion encoded single-cell sequencing (SEC-seq) uncovers gene expression signatures associated with high VEGF-A secretion in mesenchymal stromal cells

分泌编码单细胞测序 (SEC-seq) 揭示了与间充质基质细胞中高 VEGF-A 分泌相关的基因表达特征

Oct4:Sox2 binding is essential for establishing but not maintaining active and silent states of dynamically regulated genes in pluripotent cells

Oct4：Sox2 结合对于多能细胞中动态调控基因的建立（但不维持）活跃和沉默状态至关重要

Transcriptional analysis of cystic fibrosis airways at single-cell resolution reveals altered epithelial cell states and composition

对囊性纤维化气道进行单细胞分辨率的转录组分析揭示了上皮细胞状态和组成的改变

SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition

SARS-CoV-2 感染会改变宿主细胞代谢，并且可能易受 mTORC1 抑制的影响

Species-Specific Relationships between DNA and Chromatin Properties of CpG Islands in Embryonic Stem Cells and Differentiated Cells

胚胎干细胞和分化细胞中 CpG 岛 DNA 和染色质特性之间的物种特异性关系

Direct Exposure to SARS-CoV-2 and Cigarette Smoke Increases Infection Severity and Alters the Stem Cell-Derived Airway Repair Response

直接接触SARS-CoV-2病毒和香烟烟雾会加重感染严重程度并改变干细胞衍生的气道修复反应。