日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An adapted consensus protein design strategy for identifying globally optimal biotherapeutics

一种用于识别全局最优生物治疗药物的改进型共识蛋白设计策略

Yanyun Liu ,Kenny Tsang ,Michelle Mays ,Gale Hansen ,Jeffrey Chiecko ,Maureen Crames ,Yangjie Wei ,Weijie Zhou ,Chase Fredrick ,James Hu ,Dongmei Liu ,Douglas Gebhard ,Zhong-Fu Huang ,Akshita Datar ,Anthony Kronkaitis ,Kristina Gueneva-Boucheva ,Daniel Seeliger ,Fei Han ,Saurabh Sen ,Srinath Kasturirangan ,Justin M Scheer ,Andrew E Nixon ,Tadas Panavas ,Michael S Marlow ,Sandeep Kumar

Antibodies with Weakly Basic Isoelectric Points Minimize Trade-offs between Formulation and Physiological Colloidal Properties

具有弱碱性等电点的抗体可最大限度地减少配方和生理胶体性质之间的权衡

Priyanka Gupta, Emily K Makowski, Sandeep Kumar, Yulei Zhang, Justin M Scheer, Peter M Tessier

Intrinsic physicochemical profile of marketed antibody-based biotherapeutics

已上市抗体生物治疗药物的内在物理化学特征

Lucky Ahmed, Priyanka Gupta, Kyle P Martin, Justin M Scheer, Andrew E Nixon, Sandeep Kumar

Identification and characterization of an octameric PEG-protein conjugate system for intravitreal long-acting delivery to the back of the eye

鉴定和表征用于玻璃体内长效递送至眼后部的八聚体 PEG-蛋白质结合系统

Whitney Shatz, Philip E Hass, Nikhil Peer, Maciej T Paluch, Craig Blanchette, Guanghui Han, Wendy Sandoval, Ashley Morando, Kelly M Loyet, Vladimir Bantseev, Helen Booler, Susan Crowell, Amrita Kamath, Justin M Scheer, Robert F Kelley

Protein engineering to increase the potential of a therapeutic antibody Fab for long-acting delivery to the eye

蛋白质工程可提高治疗性抗体 Fab 长效递送至眼部的潜力

Devin Tesar, Jacob Luoma, Emily A Wyatt, Catherine Shi, Whitney Shatz, Philip E Hass, Mary Mathieu, Li Yi, Jacob E Corn, Katie F Maass, Kathryn Wang, Michelle Z Dion, Nisana Andersen, Kelly M Loyet, Menno van Lookeren Campagne, Karthikan Rajagopal, Leslie Dickmann, Justin M Scheer, Robert F Kelley

bisFabs: Tools for rapidly screening hybridoma IgGs for their activities as bispecific antibodies

bisFabs:快速筛选杂交瘤 IgG 作为双特异性抗体活性的工具

Sanket Patke, Ji Li, Peiyin Wang, Dion Slaga, Jennifer Johnston, Sunil Bhakta, Siler Panowski, Liping L Sun, Teemu Junttila, Justin M Scheer, Diego A Ellerman

Development of a human IgG4 bispecific antibody for dual targeting of interleukin-4 (IL-4) and interleukin-13 (IL-13) cytokines

开发人类 IgG4 双特异性抗体,用于双重靶向白细胞介素 4 (IL-4) 和白细胞介素 13 (IL-13) 细胞因子

Christoph Spiess, Jack Bevers 3rd, Janet Jackman, Nancy Chiang, Gerald Nakamura, Michael Dillon, Hongbin Liu, Patricia Molina, J Michael Elliott, Whitney Shatz, Justin M Scheer, Glen Giese, Josefine Persson, Yin Zhang, Mark S Dennis, James Giulianotti, Prateek Gupta, Dorothea Reilly, Enzo Palma, Jia

Reorienting the Fab domains of trastuzumab results in potent HER2 activators

重新调整曲妥珠单抗的 Fab 结构域可产生强效的 HER2 激活剂

Justin M Scheer, Wendy Sandoval, J Michael Elliott, Lily Shao, Elizabeth Luis, Sock-Cheng Lewin-Koh, Gabriele Schaefer, Richard Vandlen

Development of a two-part strategy to identify a therapeutic human bispecific antibody that inhibits IgE receptor signaling

开发一种双特异性抗体来识别治疗性人类双特异性抗体,以抑制 IgE 受体信号传导

Janet Jackman, Yongmei Chen, Arthur Huang, Barbara Moffat, Justin M Scheer, Steven R Leong, Wyne P Lee, Juan Zhang, Navneet Sharma, Yanmei Lu, Suhasini Iyer, Robert L Shields, Nancy Chiang, Michele C Bauer, Diana Wadley, Merone Roose-Girma, Richard Vandlen, Daniel G Yansura, Yan Wu, Lawren C Wu