Coexistent PTEN and PIK3CA alterations hyperactivate mTORC1 signaling in endometrial cancers and cause their selective sensitivity to mTORC1 inhibition
PTEN 和 PIK3CA 的共存改变会过度激活子宫内膜癌中的 mTORC1 信号通路,并导致其对 mTORC1 抑制剂的选择性敏感性。
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doi:10.64898/2026.02.12.705558
Solomon, Hilla; Mukherjee, Radha; Yang, Yu Chi; Meredith, Julia; Schram, Alison M; Yi, Sang Ah; Chen, Xiaoping; Tribuzio, Michael; Gundlapalli, Harika; Meyerowitz, Justin; de Stanchina, Elisa; Weigelt, Britta; An, Heeseon; Barry, Simon T; Smith, Jacqueline A M; Singh, Mallika; Rosen, Neal