An aminosterol breaks the autocatalytic cycle of Aβ(42) aggregation and protects cell membranes from its soluble aggregates
氨基甾醇可破坏Aβ(42)聚集的自催化循环,并保护细胞膜免受其可溶性聚集体的侵害。
期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2417944122
Fallot, Lucas B; Pinc, Johnathan R; Buselmeier, Joseph E; Palchak, Julia C; Shroff, Supria S; Zang, Kaitlyn; Rinauro, Dillon J; Bacon, Kate M; Nguyen, Michael; Schleck, Mary Claire; Cornell, Alyssa R; Oshidar, Alexandra; Darrell, Donald J; Gabriel, Justus M; Wright, Aidan K; Sasser, Liam R; Kreiser, Ryan P; Burpo, F John; Santambrogio, Alessia; Xu, Peifeng; Kubiak, Robert W 2nd; Loverde, Joseph; Jaffett, Victor A; Toole, Justin R; Barbut, Denise; Zasloff, Michael; Chiti, Fabrizio; Dear, Alexander J; Vendruscolo, Michele; Limbocker, Ryan