日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Peptidoglycan architecture dictates protein interactions, tissue tropism, and arthritis in the Lyme disease spirochete Borrelia burgdorferi

肽聚糖结构决定了莱姆病螺旋体伯氏疏螺旋体(Borrelia burgdorferi)的蛋白质相互作用、组织趋向性和关节炎。

Ahmad, Saadman S; Ebohon, Osamudiamen; McClune, Mecaila E; Trimble, Rebecca N; Kellogg, Casey N; Booth, Carmen J; Zückert, Wolfram R; Jutras, Brandon L

A high-resolution screen identifies a preexisting beta-lactam that specifically treats Lyme disease in mice.

高分辨率筛选发现了一种预先存在的β-内酰胺类抗生素,该抗生素专门用于治疗小鼠的莱姆病

Gabby Maegan E, Bandara Abey, Outrata L M, Ebohon Osamudiamen, Ahmad Saadman S, Dressler Jules M, McClune Mecaila E, Trimble Rebecca N, Mullen Lainey, Jutras Brandon L

The peptidoglycan of Borrelia burgdorferi can persist in discrete tissues and cause systemic responses consistent with chronic illness.

伯氏疏螺旋体的肽聚糖可以持续存在于特定组织中,并引起与慢性疾病一致的全身反应

McClune Mecaila E, Ebohon Osamudiamen, Dressler Jules M, Davis Marisela M, Tupik Juselyn D, Lochhead Robert B, Booth Carmen J, Steere Allen C, Jutras Brandon L

Noninvasive Analysis of Peptidoglycan from Living Animals

对活体动物肽聚糖进行无创分析

Ocius, Karl L; Kolli, Sree H; Ahmad, Saadman S; Dressler, Jules M; Chordia, Mahendra D; Jutras, Brandon L; Rutkowski, Melanie R; Pires, Marcos M

A large screen identifies beta-lactam antibiotics which can be repurposed to target the syphilis agent.

大型筛选器可识别出β-内酰胺类抗生素,这些抗生素可以重新用于治疗梅毒

Hayes Kathryn A, Dressler Jules M, Norris Steven J, Edmondson Diane G, Jutras Brandon L

Recent Progress in Lyme Disease and Remaining Challenges

莱姆病研究的最新进展及尚存挑战

Bobe, Jason R; Jutras, Brandon L; Horn, Elizabeth J; Embers, Monica E; Bailey, Allison; Moritz, Robert L; Zhang, Ying; Soloski, Mark J; Ostfeld, Richard S; Marconi, Richard T; Aucott, John; Ma'ayan, Avi; Keesing, Felicia; Lewis, Kim; Ben Mamoun, Choukri; Rebman, Alison W; McClune, Mecaila E; Breitschwerdt, Edward B; Reddy, Panga Jaipal; Maggi, Ricardo; Yang, Frank; Nemser, Bennett; Ozcan, Aydogan; Garner, Omai; Di Carlo, Dino; Ballard, Zachary; Joung, Hyou-Arm; Garcia-Romeu, Albert; Griffiths, Roland R; Baumgarth, Nicole; Fallon, Brian A

Borrelia burgdorferi peptidoglycan is a persistent antigen in patients with Lyme arthritis

伯氏疏螺旋体肽聚糖是莱姆关节炎患者体内持续存在的抗原

Jutras, Brandon L; Lochhead, Robert B; Kloos, Zachary A; Biboy, Jacob; Strle, Klemen; Booth, Carmen J; Govers, Sander K; Gray, Joe; Schumann, Peter; Vollmer, Waldemar; Bockenstedt, Linda K; Steere, Allen C; Jacobs-Wagner, Christine

Posttranscriptional self-regulation by the Lyme disease bacterium's BpuR DNA/RNA-binding protein

莱姆病细菌BpuR DNA/RNA结合蛋白的转录后自我调控

Jutras, Brandon L; Jones, Grant S; Verma, Ashutosh; Brown, Nicholas A; Antonicello, Alyssa D; Chenail, Alicia M; Stevenson, Brian