日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Inhibitor design to target a unique feature in the folate pocket of Staphylococcus aureus dihydrofolate reductase

抑制剂设计针对金黄色葡萄球菌二氢叶酸还原酶叶酸袋中的独特功能

N Prasad Muddala, John C White, Baskar Nammalwar, Ian Pratt, Leonard M Thomas, Richard A Bunce, K Darrell Berlin, Christina R Bourne

SHetA2 interference with mortalin binding to p66shc and p53 identified using drug-conjugated magnetic microspheres

使用药物偶联磁性微球鉴定 SHetA2 对 Mortalin 与 p66shc 和 p53 结合的干扰

Doris Mangiaracina Benbrook, Baskar Nammalwar, Andrew Long, Hiroyuki Matsumoto, Anil Singh, Richard A Bunce, K Darrell Berlin

The structure and competitive substrate inhibition of dihydrofolate reductase from Enterococcus faecalis reveal restrictions to cofactor docking

粪肠球菌二氢叶酸还原酶的结构和竞争性底物抑制揭示了辅因子对接的限制

Bourne, Christina R; Wakeham, Nancy; Webb, Nicole; Nammalwar, Baskar; Bunce, Richard A; Berlin, K Darrell; Barrow, William W

Comparative Study of the Frech Catalyst with Two Conventional Catalysts in the Heck Synthesis of 2,4-Diaminopyrimidine-based Antibiotics

Frech催化剂与两种传统催化剂在Heck法合成2,4-二氨基嘧啶类抗生素中的比较研究

Nammalwar, Baskar; Bunce, Richard A; Berlin, K Darrell; Bourne, Christina R; Bourne, Philip C; Barrow, Esther W; Barrow, William W

Structure-activity relationship for enantiomers of potent inhibitors of B. anthracis dihydrofolate reductase

炭疽杆菌二氢叶酸还原酶强效抑制剂对映异构体的构效关系

Bourne, Christina R; Wakeham, Nancy; Nammalwar, Baskar; Tseitin, Vladimir; Bourne, Philip C; Barrow, Esther W; Mylvaganam, Shankari; Ramnarayan, Kal; Bunce, Richard A; Berlin, K Darrell; Barrow, William W

Inhibition of bacterial dihydrofolate reductase by 6-alkyl-2,4-diaminopyrimidines

6-烷基-2,4-二氨基嘧啶对细菌二氢叶酸还原酶的抑制作用

Nammalwar, Baskar; Bourne, Christina R; Bunce, Richard A; Wakeham, Nancy; Bourne, Philip C; Ramnarayan, Kal; Mylvaganam, Shankari; Berlin, K Darrell; Barrow, Esther W; Barrow, William W

Development of flexible-heteroarotinoids for kidney cancer

开发用于肾癌治疗的柔性杂环芳烃类化合物

Liu, Tongzu; Masamha, Chioniso Patience; Chengedza, Shylet; Berlin, K Darrell; Lightfoot, Stan; He, Feng; Benbrook, Doris Mangiaracina

Crystal structure of Bacillus anthracis dihydrofolate reductase with the dihydrophthalazine-based trimethoprim derivative RAB1 provides a structural explanation of potency and selectivity

炭疽杆菌二氢叶酸还原酶与二氢酞嗪类甲氧苄啶衍生物RAB1的晶体结构提供了效力和选择性的结构解释。

Bourne, Christina R; Bunce, Richard A; Bourne, Philip C; Berlin, K Darrell; Barrow, Esther W; Barrow, William W