日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Modified Polycyclic Compounds Rescue Mis-splicing in Myotonic Dystrophy Type 1 Disease Models.

修饰的多环化合物可挽救 1 型强直性肌营养不良症疾病模型中的错误剪接。

Frias Jesus A, Hicks Sawyer M, Mazdiyasni Hormoz, Mishra Subodh K, Sarkar Kahini, Yeboah Clara, LeFever Noah M, Scotti Marina M, Zeghal Hana, Brandt Naomi, Vangaveti Sweta, Chakma Pramita, Wang Ting, Reid Tammy S, McMichael Omari, Crumbaugh Christopher, Provenzano Marina, Hale Melissa A, Cleary John D, Johnson Nicholas E, Wang Eric T, Reddy Kaalak, Berglund J Andrew

Identification of enzymatically modified isoquercitrin as a therapeutic lead for myotonic dystrophy type 1

酶修饰异槲皮苷作为1型强直性肌营养不良症治疗先导化合物的鉴定

Mishra, Subodh K; Hicks, Sawyer M; Frias, Jesus A; Zhang, Jing; Handley, Mark T; Vangaveti, Sweta; Reid, Tammy S; Pandey, Aradhana; McMichael, Omari; Crumbaugh, Christopher; Provenzano, Marina; Hale, Melissa A; Johnson, Nicholas E; Nakamori, Masayuki; Cleary, John D; Reddy, Kaalak; Berglund, J Andrew

Inosine misincorporation into mRNA triggers the integrated stress response and activates an innate immune gene expression signature.

肌苷错误掺入mRNA会触发整合应激反应,并激活先天免疫基因表达特征。

Schroader Jacob H, Adade Naa N, Adade Emmanuel E, Bratslavsky Mark A, Shorrock Hannah K, Smith Bradley R, Zhou Ting, Lotz Steven, Bertucci Taylor, Temple Sally, Valm Alex M, Pager Cara T, Berglund J Andrew, Handley Mark T, Fuchs Gabriele, Reddy Kaalak

The unusual structural properties and potential biological relevance of switchback DNA

折返 DNA 的独特结构特性和潜在生物学意义

Bharath Raj Madhanagopal, Hannah Talbot, Arlin Rodriguez, Jiss Maria Louis, Hana Zeghal, Sweta Vangaveti, Kaalak Reddy, Arun Richard Chandrasekaran

Inosine-Induced Base Pairing Diversity during Reverse Transcription

肌苷诱导的逆转录过程中碱基配对多样性

Zheng, Ya Ying; Reddy, Kaalak; Vangaveti, Sweta; Sheng, Jia

Expression levels of core spliceosomal proteins modulate the MBNL-mediated spliceopathy in DM1

核心剪接体蛋白的表达水平调节 DM1 中的 MBNL 介导的剪接病

Jiss M Louis, Jesus A Frias, Jacob H Schroader, Lindsey A Jones, Emily E Davey, Claudia D Lennon, Jacob Chacko, John D Cleary, J Andrew Berglund, Kaalak Reddy

The unusual structural properties and potential biological relevance of switchback DNA

折返 DNA 的独特结构特性和潜在生物学意义

Bharath Raj Madhanagopal, Hannah Talbot, Arlin Rodriguez, Jiss Maria Louis, Hana Zeghal, Sweta Vangaveti, Kaalak Reddy, Arun Richard Chandrasekaran

Quercetin selectively reduces expanded repeat RNA levels in models of myotonic dystrophy

槲皮素选择性降低肌强直性营养不良模型中的扩增重复 RNA 水平

Subodh K Mishra, Sawyer M Hicks, Jesus A Frias, Sweta Vangaveti, Masayuki Nakamori, John D Cleary, Kaalak Reddy, J Andrew Berglund

Disease-associated inosine misincorporation into RNA hinders translation

疾病相关的肌苷错误掺入 RNA 会阻碍翻译

Jacob H Schroader, Lindsey A Jones, Ryan Meng, Hannah K Shorrock, Jared I Richardson, Sharon M Shaughnessy, Qishan Lin, Thomas J Begley, J Andrew Berglund, Gabriele Fuchs, Mark T Handley, Kaalak Reddy

CCG•CGG interruptions in high-penetrance SCA8 families increase RAN translation and protein toxicity

高外显率SCA8家族中的CCG•CGG中断会增加RAN翻译和蛋白质毒性

Barbara A Perez ,Hannah K Shorrock ,Monica Banez-Coronel ,Tao Zu ,Lisa El Romano ,Lauren A Laboissonniere ,Tammy Reid ,Yoshio Ikeda ,Kaalak Reddy ,Christopher M Gomez ,Thomas Bird ,Tetsuo Ashizawa ,Lawrence J Schut ,Alfredo Brusco ,J Andrew Berglund ,Lis F Hasholt ,Jorgen E Nielsen ,S H Subramony ,Laura Pw Ranum