Spatial transcriptomic analysis of Sonic hedgehog medulloblastoma identifies that the loss of heterogeneity and promotion of differentiation underlies the response to CDK4/6 inhibition
对Sonic hedgehog髓母细胞瘤的空间转录组分析表明,异质性的丧失和分化的促进是CDK4/6抑制剂作用的基础。
期刊:Genome Medicine
影响因子:10.4
doi:10.1186/s13073-023-01185-4
Tuan Vo ,Brad Balderson ,Kahli Jones ,Guiyan Ni ,Joanna Crawford ,Amanda Millar ,Elissa Tolson ,Matthew Singleton ,Marija Kojic ,Thomas Robertson ,Shaun Walters ,Onkar Mulay ,Dharmesh D Bhuva ,Melissa J Davis ,Brandon J Wainwright # ,Quan Nguyen # ,Laura A Genovesi #