日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PAC-FOS: A novel translational concordance framework identifies preclinical seizure models with highest predictive validity for clinical focal onset seizures

PAC-FOS:一种新型转化一致性框架,用于识别对临床局灶性癫痫发作具有最高预测效度的临床前癫痫模型

Anderson, Lyndsey L; Kahlig, Kristopher M; Barker-Haliski, Melissa L; Matthews, Lillian G; Toop, Hamish D; Hannigan, Brian; French, Jacqueline; White, H Steve; Souza, Marcio; Petrou, Steven

The novel persistent sodium current inhibitor PRAX-562 has potent anticonvulsant activity with improved protective index relative to standard of care sodium channel blockers.

新型持续性钠电流抑制剂 PRAX-562 具有强效抗惊厥活性,与标准钠通道阻滞剂相比,其保护指数有所提高

Kahlig Kristopher M, Scott Liam, Hatch Robert J, Griffin Andrew, Martinez Botella Gabriel, Hughes Zoë A, Wittmann Marion

Discovery of the First Orally Available, Selective K(Na)1.1 Inhibitor: In Vitro and In Vivo Activity of an Oxadiazole Series

首个口服选择性K(Na)1.1抑制剂的发现:恶二唑系列化合物的体外和体内活性

Griffin, Andrew M; Kahlig, Kristopher M; Hatch, Robert John; Hughes, Zoë A; Chapman, Mark L; Antonio, Brett; Marron, Brian E; Wittmann, Marion; Martinez-Botella, Gabriel

Early somatic mosaicism is a rare cause of long-QT syndrome

早期体细胞嵌合是长QT综合征的一种罕见病因。

Priest, James Rush; Gawad, Charles; Kahlig, Kristopher M; Yu, Joseph K; O'Hara, Thomas; Boyle, Patrick M; Rajamani, Sridharan; Clark, Michael J; Garcia, Sarah T K; Ceresnak, Scott; Harris, Jason; Boyle, Sean; Dewey, Frederick E; Malloy-Walton, Lindsey; Dunn, Kyla; Grove, Megan; Perez, Marco V; Neff, Norma F; Chen, Richard; Maeda, Katsuhide; Dubin, Anne; Belardinelli, Luiz; West, John; Antolik, Christian; Macaya, Daniela; Quertermous, Thomas; Trayanova, Natalia A; Quake, Stephen R; Ashley, Euan A

SCN1A splice variants exhibit divergent sensitivity to commonly used antiepileptic drugs

SCN1A剪接变体对常用抗癫痫药物表现出不同的敏感性

Thompson, Christopher H; Kahlig, Kristopher M; George, Alfred L Jr

Multiplexed transposon-mediated stable gene transfer in human cells

人类细胞中多重转座子介导的稳定基因转移

Kahlig, Kristopher M; Saridey, Sai K; Kaja, Aparna; Daniels, Melissa A; George, Alfred L Jr; Wilson, Matthew H

Propranolol blocks cardiac and neuronal voltage-gated sodium channels

普萘洛尔阻断心脏和神经元电压门控钠通道

Wang, Dao W; Mistry, Akshitkumar M; Kahlig, Kristopher M; Kearney, Jennifer A; Xiang, Jizhou; George, Alfred L Jr

Impaired NaV1.2 function and reduced cell surface expression in benign familial neonatal-infantile seizures

良性家族性新生儿-婴儿癫痫中NaV1.2功能受损和细胞表面表达减少

Misra, Sunita N; Kahlig, Kristopher M; George, Alfred L Jr