日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Hepatic glutathione depletion ameliorates MASLD through selective protein oxidation and inhibition of lipogenesis.

肝脏谷胱甘肽耗竭可通过选择性蛋白质氧化和抑制脂肪生成来改善 MASLD。

期刊:Journal of Clinical Investigation
影响因子:13.6
doi:10.1172/JCI197556
Liu Xiang-Yu, Wang Guoxiao, Yu Yingying, Xiao Haopeng, Oh-Hashi Kentaro, Shi Xu, Zheng Shuning, Gerszten Robert, Kahn C Ronald
Mas
发表日期：2026
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Fatty acid regulation of feeding in Caenorhabditis elegans reveals the potential ancestral origin of a GLP-1-like multiagonist signaling system

秀丽隐杆线虫中脂肪酸对摄食的调控揭示了GLP-1样多激动剂信号系统的潜在祖先起源

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2530979123
Zhu, Feimei; Castillo-Quan, Jorge Iván; Ogawa, Takafumi; Wu, Ziyun; Ding, Lang; Sura, Mansi; Watanabe, Yoshiyuki; Lentschat, Hannah; Fernández-Cárdenas, L Paulette; Dag, Ugur; Beck-Sickinger, Annette; Wang, Meng C; Kahn, C Ronald; Blackwell, T Keith
信号转导
GLP-1
C. elegans
代谢
发表日期：2026
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Portal vein-enriched metabolites as intermediate regulators of the gut microbiome in insulin resistance.

门静脉富集代谢物作为肠道微生物群在胰岛素抵抗中的中间调节因子。

期刊:Cell Metabolism
影响因子:30.9
doi:10.1016/j.cmet.2025.08.005
Muñoz Vitor Rosetto, Moreau Francois, Soto Marion, Watanabe Yoshiyuki, Pham Loc-Duyen, Zhong Jimmy, Zimmerman Sam, Brandao Bruna B, Girdhar Khyati, Avila Julian, Pan Hui, Dreyfuss Jonathan M, Mi Michael Y, Gerszten Robert E, Altindis Emrah, Kostic Aleksandar, Clish Clary B, Kahn C Ronald
微生物学
发表日期：2025
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Cell-intrinsic insulin signaling defects in human iPS cell-derived hepatocytes in type 2 diabetes.

2 型糖尿病中人类 iPS 细胞衍生肝细胞的细胞内在胰岛素信号传导缺陷

期刊:Journal of Clinical Investigation
影响因子:13.6
doi:10.1172/JCI183513
Gattu Arijeet K, Tanzer Maria, Yaron-Barir Tomer M, Johnson Jared L, Jayavelu Ashok Kumar, Pan Hui, Dreyfuss Jonathan M, Cantley Lewis C, Mann Matthias, Kahn C Ronald
细胞生物学
糖尿病
Human
发表日期：2025
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Loss of insulin signaling in microglia impairs cellular uptake of Aβ and neuroinflammatory response exacerbating AD-like neuropathology

小胶质细胞中胰岛素信号的缺失会损害细胞对Aβ的摄取和神经炎症反应，从而加剧类似阿尔茨海默病（AD）的神经病理学改变。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2501527122
Chen, Wenqiang; Liu, Xiangyu; Muñoz, Vitor Rosetto; Kahn, C Ronald
胶质细胞
炎症
炎症/感染
信号转导
阿尔茨海默症
神经科学
细胞生物学
神经炎症
免疫/内分泌
发表日期：2025
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Lrtm1: A Novel Sensor of Insulin Signaling and Regulator of Metabolism and Activity.

Lrtm1：一种新型的胰岛素信号传感器和代谢及活动调节器

期刊:Diabetes
影响因子:7.5
doi:10.2337/db24-1031
Yu Yingying, Wang Guoxiao, Chen Wenqiang, Liu Xiangyu, Munoz Vitor Rosetto, Cai Weikang, Gomes Antonio S, Kahn C Ronald
代谢
发表日期：2025
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Response to Comment on Samovski et al. Effect of Marked Weight Loss on Adipose Tissue Biology in People With Obesity and Type 2 Diabetes. Diabetes Care 2025;48:1342-1351

对 Samovski 等人发表的题为“显著体重减轻对肥胖和 2 型糖尿病患者脂肪组织生物学的影响”的文章的回应。Diabetes Care 2025;48:1342-1351

期刊:
影响因子:
doi:10.2337/dci25-0101
Samovski, Dmitri; Smith, Gordon I; Palacios, Hector; Pietka, Terri; Fuchs, Anja; Patti, Gary J; Nawaz, Allah; Kahn, C Ronald; Klein, Samuel
糖尿病
351
肥胖
代谢
发表日期：2025
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Effect of Marked Weight Loss on Adipose Tissue Biology in People With Obesity and Type 2 Diabetes

显著减重对肥胖和2型糖尿病患者脂肪组织生物学的影响

期刊:
影响因子:
doi:10.2337/dc24-2739
Samovski, Dmitri; Smith, Gordon I; Palacios, Hector; Pietka, Terri; Fuchs, Anja; Patti, Gary J; Nawaz, Allah; Kahn, C Ronald; Klein, Samuel
糖尿病
肥胖
代谢
发表日期：2025
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Protein Kinase C δ: a critical hub regulating macrophage immunomodulatory functions during Mycobacterium tuberculosis infection.

蛋白激酶 C α：结核分枝杆菌感染期间调节巨噬细胞免疫调节功能的关键枢纽

期刊:
影响因子:
doi:10.1101/2025.05.19.653976
Hazra Rudranil, Ozturk Mumin, Peton Nashied, Ganief Tariq, Poswayo Sibongiseni Kl, Rousseau Robert P, Naidoo Saiyukthi, Jones Shelby-Sara, Savulescu Anca F, Moseki Raymond M, Abhimanyu, Du Plessis Nelita, Blackburn Jonathan, Mhlanga Musa M, Kahn C Ronald, Brombacher Frank, Wilkinson Robert J, Parihar Suraj P
细胞生物学
发表日期：2025
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Ketohexokinase-C regulates global protein acetylation to decrease carnitine palmitoyltransferase 1a-mediated fatty acid oxidation

酮己糖激酶C通过调节整体蛋白质乙酰化来降低肉碱棕榈酰转移酶1a介导的脂肪酸氧化。

期刊:Journal of Hepatology
影响因子:33
doi:10.1016/j.jhep.2023.02.010
Helsley, Robert N; Park, Se-Hyung; Vekaria, Hemendra J; Sullivan, Patrick G; Conroy, Lindsey R; Sun, Ramon C; Romero, María Del Mar; Herrero, Laura; Bons, Joanna; King, Christina D; Rose, Jacob; Meyer, Jesse G; Schilling, Birgit; Kahn, C Ronald; Softic, Samir
信号转导
乙酰化
表观遗传
代谢
发表日期：2023
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