日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitis

肝脏脂滴胆固醇含量是代谢功能障碍相关性脂肪性肝炎的关键决定因素。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2502978122
Sakuma, Ikki; Gaspar, Rafael C; Nasiri, Ali R; Dufour, Sylvie; Kahn, Mario; Zheng, Jie; LaMoia, Traci E; Guerra, Mateus T; Taki, Yuki; Kawashima, Yusuke; Yimlamai, Dean; Perelis, Mark; Vatner, Daniel F; Petersen, Kitt Falk; Huttasch, Maximilian; Knebel, Birgit; Kahl, Sabine; Roden, Michael; Samuel, Varman T; Tanaka, Tomoaki; Shulman, Gerald I
肝炎
代谢
发表日期：2025
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Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitis

肝脏脂滴胆固醇含量是代谢功能障碍相关性脂肪性肝炎的关键决定因素。

期刊:
影响因子:
doi:10.1101/2025.02.25.640203
Sakuma, Ikki; Gaspar, Rafael C; Nasiri, Ali R; Dufour, Sylvie; Kahn, Mario; Zheng, Jie; LaMoia, Traci E; Guerra, Mateus T; Taki, Yuki; Kawashima, Yusuke; Yimlamai, Dean; Perelis, Mark; Vatner, Daniel F; Petersen, Kitt Falk; Huttasch, Maximilian; Knebel, Birgit; Kahl, Sabine; Roden, Michael; Samuel, Varman T; Tanaka, Tomoaki; Shulman, Gerald I
肝炎
代谢
发表日期：2025
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Hepatic ferredoxin reductase modulates mitochondrial function and iron homeostasis in metabolic dysfunction-associated steatotic liver disease

肝脏铁氧还蛋白还原酶在代谢功能障碍相关的脂肪肝疾病中调节线粒体功能和铁稳态

期刊:
影响因子:
doi:10.21203/rs.3.rs-7014857/v1
Tanaka, Tomoaki; Sakuma, Ikki; Gaspar, Rafael; Luukkonen, Panu; Hubbard, Brandon; Vatner, Daniel; Nasiri, Ali; Dufour, Sylvie; Kahn, Mario; Perelis, Mark; Taki, Yuki; Nakayama, Akitoshi; Fujimoto, Masanori; Kono, Takashi; Miki, Takashi; Yokote, Koutaro; Petersen, Kitt; Samuel, Varman; Shulman, Gerald
线粒体
脂肪肝
代谢
发表日期：2025
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Cytosolic calcium regulates hepatic mitochondrial oxidation, intrahepatic lipolysis, and gluconeogenesis via CAMKII activation.

胞质钙通过 CAMKII 激活调节肝线粒体氧化、肝内脂肪分解和糖异生

期刊:Cell Metabolism
影响因子:30.9
doi:10.1016/j.cmet.2024.07.016
LaMoia Traci E, Hubbard Brandon T, Guerra Mateus T, Nasiri Ali, Sakuma Ikki, Kahn Mario, Zhang Dongyan, Goodman Russell P, Nathanson Michael H, Sancak Yasemin, Perelis Mark, Mootha Vamsi K, Shulman Gerald I
线粒体
发表日期：2024
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SGLT2 inhibition alters substrate utilization and mitochondrial redox in healthy and failing rat hearts

SGLT2抑制剂可改变健康和衰竭大鼠心脏的底物利用率和线粒体氧化还原状态

期刊:Journal of Clinical Investigation
影响因子:13.6
doi:10.1172/JCI176708
Goedeke, Leigh; Ma, Yina; Gaspar, Rafael C; Nasiri, Ali; Lee, Jieun; Zhang, Dongyan; Galsgaard, Katrine Douglas; Hu, Xiaoyue; Zhang, Jiasheng; Guerrera, Nicole; Li, Xiruo; LaMoia, Traci; Hubbard, Brandon T; Haedersdal, Sofie; Wu, Xiaohong; Stack, John; Dufour, Sylvie; Butrico, Gina Marie; Kahn, Mario; Perry, Rachel J; Cline, Gary W; Young, Lawrence H; Shulman, Gerald I
SGLT2
线粒体
Rat
发表日期：2024
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Effect of Weight Loss on Skeletal Muscle Bioactive Lipids in People With Obesity and Type 2 Diabetes

体重减轻对肥胖和2型糖尿病患者骨骼肌生物活性脂质的影响

期刊:Diabetes
影响因子:7.5
doi:10.2337/db24-0083
Petersen, Max C; Yoshino, Mihoko; Smith, Gordon I; Gaspar, Rafael C; Kahn, Mario; Samovski, Dmitri; Shulman, Gerald I; Klein, Samuel
肥胖
代谢
糖尿病
发表日期：2024
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Distinct subcellular localisation of intramyocellular lipids and reduced PKCε/PKCθ activity preserve muscle insulin sensitivity in exercise-trained mice

肌细胞内脂质的独特亚细胞定位和降低的 PKCε/PKCθ 活性可维持运动训练小鼠的肌肉胰岛素敏感性

期刊:Diabetologia
影响因子:10.2
doi:10.1007/s00125-022-05838-8
Gaspar, Rafael C; Lyu, Kun; Hubbard, Brandon T; Leitner, Brooks P; Luukkonen, Panu K; Hirabara, Sandro M; Sakuma, Ikki; Nasiri, Ali; Zhang, Dongyan; Kahn, Mario; Cline, Gary W; Pauli, José Rodrigo; Perry, Rachel J; Petersen, Kitt F; Shulman, Gerald I
PKCε
细胞生物学
PKC
免疫/内分泌
发表日期：2023
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Inhibition of HSD17B13 protects against liver fibrosis by inhibition of pyrimidine catabolism in nonalcoholic steatohepatitis

抑制 HSD17B13 可通过抑制嘧啶分解代谢来预防非酒精性脂肪性肝炎中的肝纤维化。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2217543120
Luukkonen, Panu K; Sakuma, Ikki; Gaspar, Rafael C; Mooring, Meghan; Nasiri, Ali; Kahn, Mario; Zhang, Xian-Man; Zhang, Dongyan; Sammalkorpi, Henna; Penttilä, Anne K; Orho-Melander, Marju; Arola, Johanna; Juuti, Anne; Zhang, Xuchen; Yimlamai, Dean; Yki-Järvinen, Hannele; Petersen, Kitt Falk; Shulman, Gerald I
肝炎
代谢
发表日期：2023
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Lysophosphatidic acid triggers inflammation in the liver and white adipose tissue in rat models of 1-acyl-sn-glycerol-3-phosphate acyltransferase 2 deficiency and overnutrition

溶血磷脂酸在1-酰基-sn-甘油-3-磷酸酰基转移酶2缺乏和营养过剩的大鼠模型中引发肝脏和白色脂肪组织的炎症

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2312666120
Sakuma, Ikki; Gaspar, Rafael C; Luukkonen, Panu K; Kahn, Mario; Zhang, Dongyan; Zhang, Xuchen; Murray, Sue; Golla, Jaya Prakash; Vatner, Daniel F; Samuel, Varman T; Petersen, Kitt Falk; Shulman, Gerald I
炎症/感染
炎症
Rat
发表日期：2023
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In vivo studies on the mechanism of methylene cyclopropyl acetic acid and methylene cyclopropyl glycine-induced hypoglycemia

亚甲基环丙基乙酸和亚甲基环丙基甘氨酸诱导低血糖机制的体内研究

期刊:Biochemical Journal
影响因子:4.3
doi:10.1042/BCJ20180063
Qiu, Yang; Perry, Rachel J; Camporez, João-Paulo G; Zhang, Xian-Man; Kahn, Mario; Cline, Gary W; Shulman, Gerald I; Vatner, Daniel F
发表日期：2018
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