日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Structure-Based Evolution of G Protein-Biased μ-Opioid Receptor Agonists

基于结构的G蛋白偏向性μ-阿片受体激动剂的进化

期刊:Angewandte Chemie-International Edition
影响因子:16.9
doi:10.1002/anie.202200269
Wang, Haoqing; Hetzer, Florian; Huang, Weijiao; Qu, Qianhui; Meyerowitz, Justin; Kaindl, Jonas; Hübner, Harald; Skiniotis, Georgios; Kobilka, Brian K; Gmeiner, Peter
信号转导
发表日期：2022
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Binding pathway determines norepinephrine selectivity for the human β(1)AR over β(2)AR.

结合途径决定了去甲肾上腺素对人类β(1)AR 的选择性高于对β(2)AR 的选择性

期刊:Cell Research
影响因子:25.9
doi:10.1038/s41422-020-00424-2
Xu Xinyu, Kaindl Jonas, Clark Mary J, Hübner Harald, Hirata Kunio, Sunahara Roger K, Gmeiner Peter, Kobilka Brian K, Liu Xiangyu
Human
发表日期：2021
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Presynaptic vesicular accumulation is required for antipsychotic efficacy in psychotic-like rats

突触前囊泡的积累是精神病样大鼠抗精神病药物发挥疗效的必要条件。

期刊:Journal of Psychopharmacology
影响因子:5.5
doi:10.1177/0269881120965908
Uzuneser, Taygun C; Weiss, Eva-Maria; Dahlmanns, Jana; Kalinichenko, Liubov S; Amato, Davide; Kornhuber, Johannes; Alzheimer, Christian; Hellmann, Jan; Kaindl, Jonas; Hübner, Harald; Löber, Stefan; Gmeiner, Peter; Grömer, Teja W; Müller, Christian P
囊泡
Rat
神经科学
发表日期：2021
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An allosteric modulator binds to a conformational hub in the β(2) adrenergic receptor.

变构调节剂与β(2)肾上腺素能受体的构象枢纽结合

期刊:Nature Chemical Biology
影响因子:13.7
doi:10.1038/s41589-020-0549-2
Liu Xiangyu, Kaindl Jonas, Korczynska Magdalena, Stößel Anne, Dengler Daniela, Stanek Markus, Hübner Harald, Clark Mary J, Mahoney Jake, Matt Rachel Ann, Xu Xinyu, Hirata Kunio, Shoichet Brian K, Sunahara Roger K, Kobilka Brian K, Gmeiner Peter
信号转导
免疫/内分泌
发表日期：2020
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Basal Histamine H(4) Receptor Activation: Agonist Mimicry by the Diphenylalanine Motif.

基础组胺 H(4) 受体激活：二苯丙氨酸基序的激动剂模拟

期刊:Chemistry-A European Journal
影响因子:2.4
doi:10.1002/chem.201902801
Wifling David, Pfleger Christopher, Kaindl Jonas, Ibrahim Passainte, Kling Ralf C, Buschauer Armin, Gohlke Holger, Clark Timothy
其它
发表日期：2019
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Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists

结构导向的选择性M3毒蕈碱乙酰胆碱受体拮抗剂的开发

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.1813988115
Liu, Hongtao; Hofmann, Josefa; Fish, Inbar; Schaake, Benjamin; Eitel, Katrin; Bartuschat, Amelie; Kaindl, Jonas; Rampp, Hannelore; Banerjee, Ashutosh; Hübner, Harald; Clark, Mary J; Vincent, Sandra G; Fisher, John T; Heinrich, Markus R; Hirata, Kunio; Liu, Xiangyu; Sunahara, Roger K; Shoichet, Brian K; Kobilka, Brian K; Gmeiner, Peter
信号转导
发表日期：2018
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Structure-guided development of heterodimer-selective GPCR ligands

基于结构的异二聚体选择性GPCR配体开发

期刊:Nature Communications
影响因子:15.7
doi:10.1038/ncomms12298
Hübner, Harald; Schellhorn, Tamara; Gienger, Marie; Schaab, Carolin; Kaindl, Jonas; Leeb, Laurin; Clark, Timothy; Möller, Dorothee; Gmeiner, Peter
GPCR/Calcium/cAMP
发表日期：2016
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