日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Hijacking Extracellular Targeted Protein Degrader-Drug Conjugates for Enhanced Drug Delivery

利用细胞外靶向蛋白降解剂-药物偶联物增强药物递送

Fangzhu Zhao ,Yan Wu ,Kaitlin Schaefer ,Yun Zhang ,Kun Miao ,Zi Yao ,Snehal D Ganjave ,Kaan Kumru ,Trenton M Peters-Clarke ,Alex Inague ,James A Olzmann ,Kevin K Leung ,James A Wells

Multiscale photocatalytic proximity labeling reveals cell surface neighbors on and between cells

多尺度光催化邻近标记揭示了细胞表面及细胞间的邻近分子

Zhi Lin ,Kaitlin Schaefer ,Irene Lui ,Zi Yao ,Andrea Fossati ,Danielle L Swaney ,Ajikarunia Palar ,Andrej Sali ,James A Wells

Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability

硒蛋白翻译过程中核糖体停滞会暴露铁死亡的脆弱性。

Zhipeng Li ,Lucas Ferguson ,Kirandeep K Deol ,Melissa A Roberts ,Leslie Magtanong ,Joseph M Hendricks ,Gergey Alzaem Mousa ,Seda Kilinc ,Kaitlin Schaefer ,James A Wells ,Michael C Bassik ,Andrei Goga ,Scott J Dixon ,Nicholas T Ingolia ,James A Olzmann

Structure and reconstitution of a hydrolase complex that may release peptidoglycan from the membrane after polymerization

水解酶复合物的结构和重组,该复合物可能在聚合后从膜上释放肽聚糖。

Kaitlin Schaefer #,Tristan W Owens #,Julia E Page,Marina Santiago,Daniel Kahne,Suzanne Walker

Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2

双互补位和多价 VH 结构域阻断 ACE2 结合并中和 SARS-CoV-2

Colton J Bracken, Shion A Lim, Paige Solomon, Nicholas J Rettko, Duy P Nguyen, Beth Shoshana Zha, Kaitlin Schaefer, James R Byrnes, Jie Zhou, Irene Lui, Jia Liu, Katarina Pance; QCRG Structural Biology Consortium; Xin X Zhou, Kevin K Leung, James A Wells

Sentinel cells enable genetic detection of SARS-CoV-2 Spike protein

哨兵细胞可实现 SARS-CoV-2 刺突蛋白的基因检测

Zara Y Weinberg, Claire E Hilburger, Matthew Kim, Longxing Cao, Mir Khalid, Sarah Elmes, Devan Diwanji, Evelyn Hernandez, Jocelyne Lopez, Kaitlin Schaefer, Amber M Smith, Fengbo Zhou; QCRG Structural Biology Consortium; G Renuka Kumar, Melanie Ott, David Baker, Hana El-Samad

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

比较宿主-冠状病毒蛋白相互作用网络揭示了泛病毒疾病机制

David E Gordon # ,Joseph Hiatt # ,Mehdi Bouhaddou # ,Veronica V Rezelj # ,Svenja Ulferts # ,Hannes Braberg # ,Alexander S Jureka # ,Kirsten Obernier # ,Jeffrey Z Guo # ,Jyoti Batra # ,Robyn M Kaake # ,Andrew R Weckstein # ,Tristan W Owens # ,Meghna Gupta # ,Sergei Pourmal # ,Erron W Titus # ,Merve Cakir # ,Margaret Soucheray ,Michael McGregor ,Zeynep Cakir ,Gwendolyn Jang ,Matthew J O'Meara ,Tia A Tummino ,Ziyang Zhang ,Helene Foussard ,Ajda Rojc ,Yuan Zhou ,Dmitry Kuchenov ,Ruth Hüttenhain ,Jiewei Xu ,Manon Eckhardt ,Danielle L Swaney ,Jacqueline M Fabius ,Manisha Ummadi ,Beril Tutuncuoglu ,Ujjwal Rathore ,Maya Modak ,Paige Haas ,Kelsey M Haas ,Zun Zar Chi Naing ,Ernst H Pulido ,Ying Shi ,Inigo Barrio-Hernandez ,Danish Memon ,Eirini Petsalaki ,Alistair Dunham ,Miguel Correa Marrero ,David Burke ,Cassandra Koh ,Thomas Vallet ,Jesus A Silvas ,Caleigh M Azumaya ,Christian Billesbølle ,Axel F Brilot ,Melody G Campbell ,Amy Diallo ,Miles Sasha Dickinson ,Devan Diwanji ,Nadia Herrera ,Nick Hoppe ,Huong T Kratochvil ,Yanxin Liu ,Gregory E Merz ,Michelle Moritz ,Henry C Nguyen ,Carlos Nowotny ,Cristina Puchades ,Alexandrea N Rizo ,Ursula Schulze-Gahmen ,Amber M Smith ,Ming Sun ,Iris D Young ,Jianhua Zhao ,Daniel Asarnow ,Justin Biel ,Alisa Bowen ,Julian R Braxton ,Jen Chen ,Cynthia M Chio ,Un Seng Chio ,Ishan Deshpande ,Loan Doan ,Bryan Faust ,Sebastian Flores ,Mingliang Jin ,Kate Kim ,Victor L Lam ,Fei Li ,Junrui Li ,Yen-Li Li ,Yang Li ,Xi Liu ,Megan Lo ,Kyle E Lopez ,Arthur A Melo ,Frank R Moss 3rd ,Phuong Nguyen ,Joana Paulino ,Komal Ishwar Pawar ,Jessica K Peters ,Thomas H Pospiech Jr ,Maliheh Safari ,Smriti Sangwan ,Kaitlin Schaefer ,Paul V Thomas ,Aye C Thwin ,Raphael Trenker ,Eric Tse ,Tsz Kin Martin Tsui ,Feng Wang ,Natalie Whitis ,Zanlin Yu ,Kaihua Zhang ,Yang Zhang ,Fengbo Zhou ,Daniel Saltzberg ,Amber S Shun-Shion ,Daniel M Williams ,Kris M White ,Romel Rosales ,Thomas Kehrer ,Lisa Miorin ,Elena Moreno ,Arvind H Patel ,Suzannah Rihn ,Mir M Khalid ,Albert Vallejo-Gracia ,Parinaz Fozouni ,Camille R Simoneau ,Theodore L Roth ,David Wu ,Mohd Anisul Karim ,Maya Ghoussaini ,Ian Dunham ,Francesco Berardi ,Sebastian Weigang ,Maxime Chazal ,Jisoo Park ,James Logue ,Marisa McGrath ,Stuart Weston ,Robert Haupt ,C James Hastie ,Matthew Elliott ,Fiona Brown ,Kerry A Burness ,Elaine Reid ,Mark Dorward ,Clare Johnson ,Stuart G Wilkinson ,Anna Geyer ,Daniel M Giesel ,Carla Baillie ,Samantha Raggett ,Hannah Leech ,Rachel Toth ,Nicola Goodman ,Kathleen C Keough ,Abigail L Lind ,Kafi R Hemphill ,Jared Carlson-Stevermer ,Jennifer Oki ,Kevin Holden ,Travis Maures ,Katherine S Pollard ,Andrej Sali ,David A Agard ,Yifan Cheng ,James S Fraser ,Adam Frost ,Natalia Jura ,Tanja Kortemme ,Aashish Manglik ,Daniel R Southworth ,Robert M Stroud ,Dario R Alessi ,Paul Davies ,Matthew B Frieman ,Trey Ideker ,Carmen Abate ,Nolwenn Jouvenet ,Georg Kochs ,Brian Shoichet ,Melanie Ott ,Massimo Palmarini ,Kevan M Shokat ,Adolfo García-Sastre ,Jeremy A Rassen ,Robert Grosse ,Oren S Rosenberg ,Kliment A Verba ,Christopher F Basler ,Marco Vignuzzi ,Andrew A Peden ,Pedro Beltrao ,Nevan J Krogan

Staphylococcus aureus cell growth and division are regulated by an amidase that trims peptides from uncrosslinked peptidoglycan

金黄色葡萄球菌细胞的生长和分裂受一种酰胺酶的调控,该酶可修剪未交联的肽聚糖中的肽

Truc Do, Kaitlin Schaefer, Ace George Santiago, Kathryn A Coe, Pedro B Fernandes, Daniel Kahne, Mariana G Pinho, Suzanne Walker

Bi-paratopic and multivalent human VH domains neutralize SARS-CoV-2 by targeting distinct epitopes within the ACE2 binding interface of Spike

双互补位和多价人类 VH 结构域通过靶向 Spike 的 ACE2 结合界面内的不同表位来中和 SARS-CoV-2

Colton J Bracken, Shion A Lim, Paige Solomon, Nicholas J Rettko, Duy P Nguyen, Beth Shoshana Zha, Kaitlin Schaefer, James R Byrnes, Jie Zhou, Irene Lui, Jia Liu, Katarina Pance; QCRG Structural Biology Consortium; Xin X Zhou, Kevin K Leung, James A Wells

MreB filaments align along greatest principal membrane curvature to orient cell wall synthesis

MreB 丝状体沿着最大主膜曲率排列,以定向细胞壁合成

Saman Hussain #, Carl N Wivagg #, Piotr Szwedziak, Felix Wong, Kaitlin Schaefer, Thierry Izoré, Lars D Renner, Matthew J Holmes, Yingjie Sun, Alexandre W Bisson-Filho, Suzanne Walker, Ariel Amir, Jan Löwe, Ethan C Garner