日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19

第二代口服SARS-CoV-2主蛋白酶抑制剂:COVID-19治疗的临床候选药物

Allerton, Charlotte M N; Arcari, Joel T; Aschenbrenner, Lisa M; Avery, Melissa; Bechle, Bruce M; Behzadi, Mohammad Amin; Boras, Britton; Buzon, Leanne M; Cardin, Rhonda D; Catlin, Natasha R; Carlo, Anthony A; Coffman, Karen J; Dantonio, Alyssa; Di, Li; Eng, Heather; Farley, Kathleen A; Ferre, Rose Ann; Gernhardt, Steven S; Gibson, Scott A; Greasley, Samantha E; Greenfield, Siennah R; Hurst, Brett L; Kalgutkar, Amit S; Kimoto, Emi; Lanyon, Lorraine F; Lovett, Gabrielle H; Lian, Yajing; Liu, Wei; Martínez Alsina, Luis A; Noell, Stephen; Obach, R Scott; Owen, Dafydd R; Patel, Nandini C; Rai, Devendra K; Reese, Matthew R; Rothan, Hussin A; Sakata, Sylvie; Sammons, Matthew F; Sathish, Jean G; Sharma, Raman; Steppan, Claire M; Tuttle, Jamison B; Verhoest, Patrick R; Wei, Liuqing; Yang, Qingyi; Yurgelonis, Irina; Zhu, Yuao

Development of a sensitive LC-MS/MS assay to support human microdose study for an oral agonist of the GLP-1 receptor

开发一种灵敏的液相色谱-串联质谱(LC-MS/MS)分析方法,以支持口服GLP-1受体激动剂的人体微剂量研究。

Kadar, Eugene P; Eng, Heather; Kalgutkar, Amit S; Holliman, Christopher L; Steeno, Gregory S

A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor

人胰高血糖素样肽-1受体的小分子口服激动剂

Griffith, David A; Edmonds, David J; Fortin, Jean-Philippe; Kalgutkar, Amit S; Kuzmiski, J Brent; Loria, Paula M; Saxena, Aditi R; Bagley, Scott W; Buckeridge, Clare; Curto, John M; Derksen, David R; Dias, João M; Griffor, Matthew C; Han, Seungil; Jackson, V Margaret; Landis, Margaret S; Lettiere, Daniel; Limberakis, Chris; Liu, Yuhang; Mathiowetz, Alan M; Patel, Jayesh C; Piotrowski, David W; Price, David A; Ruggeri, Roger B; Tess, David A

Practical and Science-Based Strategy for Establishing Acceptable Intakes for Drug Product N-Nitrosamine Impurities

建立药品中N-亚硝胺杂质可接受摄入量的实用且科学的策略

Dobo, Krista L; Kenyon, Michelle O; Dirat, Olivier; Engel, Maria; Fleetwood, Andrew; Martin, Matthew; Mattano, Susan; Musso, Alyssa; McWilliams, James Christopher; Papanikolaou, Alexandros; Parris, Patricia; Whritenour, Jessica; Yu, Shu; Kalgutkar, Amit S

Biotransformation novel advances - 2021 year in review

生物转化领域最新进展——2021年回顾

Khojasteh, S Cyrus; Argikar, Upendra A; Cho, Sungjoon; Crouch, Rachel; Heck, Carley J S; Johnson, Kevin M; Kalgutkar, Amit S; King, Lloyd; Maw, Hlaing Holly; Seneviratne, Herana Kamal; Wang, Shuai; Wei, Cong; Zhang, Donglu; Jackson, Klarissa D

Comprehensive Nonclinical Safety Assessment of Nirmatrelvir Supporting Timely Development of the SARS-COV-2 Antiviral Therapeutic, Paxlovid™

对尼马替韦进行全面的非临床安全性评估,支持及时开发SARS-CoV-2抗病毒疗法Paxlovid™。

Sathish, Jean G; Bhatt, Siddhartha; DaSilva, Jamie K; Flynn, Declan; Jenkinson, Stephen; Kalgutkar, Amit S; Liu, Maggie; Manickam, Balasubramanian; Pinkstaff, Jason; Reagan, William J; Shirai, Norimitsu; Shoieb, Ahmed M; Sirivelu, Madhu; Vispute, Saurabh; Vitsky, Allison; Walters, Karen; Wisialowski, Todd A; Updyke, Lawrence W

Novel advances in biotransformation and bioactivation research - 2020 year in review

生物转化和生物活化研究的新进展——2020年回顾

Khojasteh, S Cyrus; Argikar, Upendra A; Driscoll, James P; Heck, Carley J S; King, Lloyd; Jackson, Klarissa D; Jian, Wenying; Kalgutkar, Amit S; Miller, Grover P; Kramlinger, Valerie; Rietjens, Ivonne M C M; Teitelbaum, Aaron M; Wang, Kai; Wei, Cong

SARS-CoV-2 detection in sewage samples: Standardization of method & preliminary observations

污水样本中SARS-CoV-2的检测:方法标准化及初步观察

Sharma, Deepa Kailash; Nalavade, Uma Prajwal; Kalgutkar, Kamlesh; Gupta, Nivedita; Deshpande, Jagadish Mohanrao

Myeloperoxidase inhibition in mice alters atherosclerotic lesion composition

小鼠髓过氧化物酶抑制改变动脉粥样硬化病变组成

Rachel J Roth Flach, Chunyan Su, Eliza Bollinger, Christian Cortes, Andrew W Robertson, Alan C Opsahl, Timothy M Coskran, Kevin P Maresca, Edmund J Keliher, Phillip D Yates, Albert M Kim, Amit S Kalgutkar, Leonard Buckbinder

Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models

PF-06409577激活肝脏AMPK可纠正啮齿动物和灵长类动物临床前模型中的非酒精性脂肪性肝病并降低胆固醇

Ryan M Esquejo ,Christopher T Salatto ,Jake Delmore ,Bina Albuquerque ,Allan Reyes ,Yuji Shi ,Rob Moccia ,Emily Cokorinos ,Matthew Peloquin ,Mara Monetti ,Jason Barricklow ,Eliza Bollinger ,Brennan K Smith ,Emily A Day ,Chuong Nguyen ,Kieran F Geoghegan ,John M Kreeger ,Alan Opsahl ,Jessica Ward ,Amit S Kalgutkar ,David Tess ,Lynne Butler ,Norimitsu Shirai ,Timothy F Osborne ,Gregory R Steinberg ,Morris J Birnbaum ,Kimberly O Cameron ,Russell A Miller