日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The Allosteric Regulator Inositol Phosphate Dramatically Affects the Efficacy and Selectivity of Inhibitors for Different HDAC Complexes

变构调节剂肌醇磷酸酯显著影响不同HDAC复合物抑制剂的效力和选择性。

Pytel, Wiktoria A; Patel, Urvashi; Smalley, Joshua P; Millard, Christopher J; Brown, Edward A; Pavan, Aline R; Wang, Siyu; Kalin, Jay H; Dos Santos, Jean Leandro; Cole, Philip A; Hodgkinson, James T; Schwabe, John W R

Discovery of a non-nucleoside inhibitor that binds to a novel site in the palm domain of the respiratory syncytial virus RNA-dependent RNA polymerase.

发现一种非核苷类抑制剂,可与呼吸道合胞病毒 RNA 依赖性 RNA 聚合酶掌状结构域中的新位点结合

Kalin Jay H, Yin Yanting, Tran Minh T, Piassek Madison, Fung Amy, Grosse Sandrine, Jacoby Edgar, Bhaumik Anusarka, Adhikary Suraj, Miller Robyn, Lemmens Cynthia, Lutter Ferdinand H, Pieters Serge, Cooymans Ludwig, Rombouts Geert, Oehlrich Daniel, Tomaso Sonia, Lozada Kate, Garcia Miguel Osorio, Anson Brandon, De Bruyn Suzanne, Smith-Monroy Constance, Neefs Jean-Marc, Conceição-Neto Nádia, Stoops Bart, van Vlijmen Herman, Patrick Aaron, Yu Xiaodi, Wong Victoria, Krosky Daniel, Abeywickrema Pravien, Mason Stephen, Jin Zhinan, Jonckers Tim H M, Sharma Sujata

Targeting NEDD9-SH3 with a Covalent Peptide Controls Endothelial Phenotype.

利用共价肽靶向NEDD9-SH3可控制内皮细胞表型

Samokhin Andriy O, Seo Hyuk-Soo, Leed Alison, Hajian Behnoush, Bird Gregory H, McKinney David C, Saha Progyaparamita, Daum Jacqueline, Moroco Jamie A, Yehl Jenna, Kornfilt David, Szczeniowski Anna, Petrunak Elyse, Horner Steven, Kalin Jay H, Leymarie Nancy, Kaushik Virendar K, Walensky Loren D, Cole Philip A, Oldham William M, Steinhauser Matthew L, Dhe-Paganon Sirano, Maron Bradley A

Structure of human spermine oxidase in complex with a highly selective allosteric inhibitor

人精胺氧化酶与高选择性变构抑制剂复合物的结构

Diaz, Elsie; Adhikary, Suraj; Tepper, Armand W J W; Riley, Daniel; Ortiz-Meoz, Rodrigo; Krosky, Daniel; Buyck, Christophe; Lamenca, Carolina Martinez; Llaveria, Josep; Fang, Lichao; Kalin, Jay H; Klaren, Vincent N A; Fahmy, Shorouk; Shaffer, Paul L; Kirkpatrick, Robert; Carbajo, Rodrigo J; Thomsen, Maren; Impagliazzo, Antonietta

HDAC2 targeting stabilizes the CoREST complex in renal tubular cells and protects against renal ischemia/reperfusion injury

靶向 HDAC2 可稳定肾小管细胞中的 CoREST 复合物,并保护肾脏免受缺血/再灌注损伤。

Aufhauser, David D Jr; Hernandez, Paul; Concors, Seth J; O'Brien, Ciaran; Wang, Zhonglin; Murken, Douglas R; Samanta, Arabinda; Beier, Ulf H; Krumeich, Lauren; Bhatti, Tricia R; Wang, Yanfeng; Ge, Guanghui; Wang, Liqing; Cheraghlou, Shayan; Wagner, Florence F; Holson, Edward B; Kalin, Jay H; Cole, Philip A; Hancock, Wayne W; Levine, Matthew H

Site-Specific Protein Labeling with N-Hydroxysuccinimide-Esters and the Analysis of Ubiquitin Ligase Mechanisms

利用N-羟基琥珀酰亚胺酯进行位点特异性蛋白质标记及泛素连接酶机制分析

Dempsey, Daniel R; Jiang, Hanjie; Kalin, Jay H; Chen, Zan; Cole, Philip A

Exploration of the labeling of [11C]tubastatin A at the hydroxamic acid site with [11C]carbon monoxide

利用[11C]一氧化碳对羟肟酸位点的[11C]tubastatin A进行标记的研究

Lu, Shuiyu; Zhang, Yi; Kalin, Jay H; Cai, Lisheng; Kozikowski, Alan P; Pike, Victor W

An Fc domain protein-small molecule conjugate as an enhanced immunomodulator

Fc结构域蛋白-小分子缀合物作为一种增强型免疫调节剂

Chiang, Meng-Jung; Holbert, Marc A; Kalin, Jay H; Ahn, Young-Hoon; Giddens, John; Amin, Mohammed N; Taylor, Martin S; Collins, Samuel L; Chan-Li, Yee; Waickman, Adam; Hsiao, Po-Yuan; Bolduc, David; Leahy, Daniel J; Horton, Maureen R; Wang, Lai-Xi; Powell, Jonathan D; Cole, Philip A

An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity

一种优化的RAD51抑制剂,无需迈克尔受体反应即可破坏同源重组。

Budke, Brian; Kalin, Jay H; Pawlowski, Michal; Zelivianskaia, Anna S; Wu, Megan; Kozikowski, Alan P; Connell, Philip P