日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Attenuating nicotine's effects with high affinity human anti-nicotine monoclonal antibodies

利用高亲和力人类抗尼古丁单克隆抗体减弱尼古丁的影响

Michael D Raleigh, Nicola Beltraminelli, Stephanie Fallot, Mark G LeSage, Amy Saykao, Paul R Pentel, Steve Fuller, Thomas Thisted, Zuzanna Biesova, Stephen Horrigan, Darryl Sampey, Bin Zhou, Matthew W Kalnik

Optimization of a nicotine degrading enzyme for potential use in treatment of nicotine addiction

优化尼古丁降解酶以用于治疗尼古丁成瘾

Thomas Thisted, Zuzana Biesova, Celine Walmacq, Everett Stone, Max Rodnick-Smith, Shaheda S Ahmed, Stephen K Horrigan, Bo Van Engelen, Charles Reed, Matthew W Kalnik

The nicotine-degrading enzyme NicA2 reduces nicotine levels in blood, nicotine distribution to brain, and nicotine discrimination and reinforcement in rats

尼古丁降解酶NicA2可降低大鼠血液中的尼古丁水平、减少尼古丁向大脑的分布,并减弱大鼠对尼古丁的辨别和强化作用。

Pentel, Paul R; Raleigh, Michael D; LeSage, Mark G; Thisted, Thomas; Horrigan, Stephen; Biesova, Zuzana; Kalnik, Matthew W