日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Inositol (1,4,5)-trisphosphate 5-phosphatase promotes survival of uveal melanoma by regulating oncogenic G protein-driven calcium oscillations

肌醇(1,4,5)-三磷酸5-磷酸酶通过调节致癌G蛋白驱动的钙振荡促进葡萄膜黑色素瘤的存活

Onken, Michael D; Makepeace, Carol M; Kaltenbronn, Kevin M; Demourelle-Washington, McKenzie; Piggott, Kisha D; Goldfarb, Dennis; Kast, David J; Jansen, Silvia; Blumer, Kendall J

Protein Kinase Signaling Networks Driven by Oncogenic Gq/11 in Uveal Melanoma Identified by Phosphoproteomic and Bioinformatic Analyses

通过磷酸化蛋白质组学和生物信息学分析鉴定葡萄膜黑色素瘤中致癌基因 Gq/11 驱动的蛋白激酶信号网络

Michael D Onken, Petra Erdmann-Gilmore, Qiang Zhang, Kisan Thapa, Emily King, Kevin M Kaltenbronn, Sarah E Noda, Carol M Makepeace, Dennis Goldfarb, Özgün Babur, R Reid Townsend, Kendall J Blumer

A Building Block Approach for the Total Synthesis of YM-385781

YM-385781 全合成的结构单元法

Zhu, Yu; Liu, Siyue; Zigmond, Johnny; Kaltenbronn, Kevin M; Blumer, Kendall J; Moeller, Kevin D

Building Chemical Probes Based on the Natural Products YM-254890 and FR900359: Advances toward Scalability

基于天然产物YM-254890和FR900359构建化学探针:迈向可扩展性的研究进展

Medcalf, Matthew R; Krueger, Ruby L; Medcalf, Zach T; Rosston, Peter A; Zhu, Yu; Kaltenbronn, Kevin M; Blumer, Kendall J; Moeller, Kevin D

Oncogenic Gq/11 signaling acutely drives and chronically sustains metabolic reprogramming in uveal melanoma

致癌 Gq/11 信号急性驱动并长期维持葡萄膜黑色素瘤的代谢重编程

Michael D Onken, Sarah E Noda, Kevin M Kaltenbronn, Cheryl Frankfater, Carol M Makepeace, Nikki Fettig, Kisha D Piggott, Philip L Custer, Joseph E Ippolito, Kendall J Blumer

Targeting primary and metastatic uveal melanoma with a G protein inhibitor

使用 G 蛋白抑制剂治疗原发性和转移性葡萄膜黑色素瘤

Michael D Onken, Carol M Makepeace, Kevin M Kaltenbronn, Joelle Choi, Leonel Hernandez-Aya, Katherine N Weilbaecher, Kisha D Piggott, P Kumar Rao, Carla M Yuede, Alethia J Dixon, Patrick Osei-Owusu, John A Cooper, Kendall J Blumer

Targeting nucleotide exchange to inhibit constitutively active G protein α subunits in cancer cells

靶向核苷酸交换抑制癌细胞中组成性活性 G 蛋白 α 亚基

Michael D Onken, Carol M Makepeace, Kevin M Kaltenbronn, Stanley M Kanai, Tyson D Todd, Shiqi Wang, Thomas J Broekelmann, Prabakar Kumar Rao, John A Cooper, Kendall J Blumer

Regulation of neurite morphogenesis by interaction between R7 regulator of G protein signaling complexes and G protein subunit Gα13

通过 G 蛋白信号复合物的 R7 调节剂与 G 蛋白亚基 Gα13 之间的相互作用来调节神经突形态发生

Stephanie L Scherer, Matthew D Cain, Stanley M Kanai, Kevin M Kaltenbronn, Kendall J Blumer

Breast cancer cell targeting by prenylation inhibitors elucidated in living animals with a bioluminescence reporter

利用生物发光报告基因在活体动物中阐明异戊烯化抑制剂对乳腺癌细胞的靶向作用

Sharon L Chinault, Julie L Prior, Kevin M Kaltenbronn, Anya Penly, Katherine N Weilbaecher, David Piwnica-Worms, Kendall J Blumer

GIRK channel modulation by assembly with allosterically regulated RGS proteins

GIRK通道通过与变构调节的RGS蛋白组装而发生调控。

Zhou, Hao; Chisari, Mariangela; Raehal, Kirsten M; Kaltenbronn, Kevin M; Bohn, Laura M; Mennerick, Steven J; Blumer, Kendall J