日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Charting γ-secretase substrates by explainable AI.

利用可解释人工智能绘制 α-分泌酶底物图

Breimann Stephan, Kamp Frits, Basset Gabriele, Abou-Ajram Claudia, Güner Gökhan, Yanagida Kanta, Okochi Masayasu, Müller Stephan A, Lichtenthaler Stefan F, Langosch Dieter, Frishman Dmitrij, Steiner Harald

Endotoxinemia Accelerates Atherosclerosis Through Electrostatic Charge-Mediated Monocyte Adhesion

内毒素血症通过静电荷介导的单核细胞黏附加速动脉粥样硬化

Schumski, Ariane; Ortega-Gómez, Almudena; Wichapong, Kanin; Winter, Carla; Lemnitzer, Patricia; Viola, Joana R; Pinilla-Vera, Mayra; Folco, Eduardo; Solis-Mezarino, Victor; Völker-Albert, Moritz; Maas, Sanne L; Pan, Chang; Perez Olivares, Laura; Winter, Janine; Hackeng, Tilman; Karlsson, Mikael C I; Zeller, Tanja; Imhof, Axel; Baron, Rebecca M; Nicolaes, Gerry A F; Libby, Peter; Maegdefessel, Lars; Kamp, Frits; Benoit, Martin; Döring, Yvonne; Soehnlein, Oliver

The Glycosylation Site of Myelin Oligodendrocyte Glycoprotein Affects Autoantibody Recognition in a Large Proportion of Patients

髓鞘少突胶质细胞糖蛋白的糖基化位点影响很大一部分患者的自身抗体识别

Marti Fernandez, Iris; Macrini, Caterina; Krumbholz, Markus; Hensbergen, Paul J; Hipgrave Ederveen, Agnes L; Winklmeier, Stephan; Vural, Atay; Kurne, Asli; Jenne, Dieter; Kamp, Frits; Gerdes, Lisa Ann; Hohlfeld, Reinhard; Wuhrer, Manfred; Kümpfel, Tania; Meinl, Edgar

Intramembrane proteolysis of β-amyloid precursor protein by γ-secretase is an unusually slow process

γ-分泌酶对β-淀粉样前体蛋白的膜内蛋白水解是一个异常缓慢的过程。

Kamp, Frits; Winkler, Edith; Trambauer, Johannes; Ebke, Amelie; Fluhrer, Regina; Steiner, Harald

Modelling Ser129 phosphorylation inhibits membrane binding of pore-forming alpha-synuclein oligomers

Ser129磷酸化模型抑制成孔α-突触核蛋白寡聚体的膜结合

Nübling, Georg Sebastian; Levin, Johannes; Bader, Benedikt; Lorenzl, Stefan; Hillmer, Andreas; Högen, Tobias; Kamp, Frits; Giese, Armin

Generation of Alzheimer disease-associated amyloid β42/43 peptide by γ-secretase can be inhibited directly by modulation of membrane thickness.

α-分泌酶产生的阿尔茨海默病相关淀粉样蛋白β42/43肽可通过调节膜厚度直接抑制

Winkler Edith, Kamp Frits, Scheuring Johannes, Ebke Amelie, Fukumori Akio, Steiner Harald

Two different binding modes of α-synuclein to lipid vesicles depending on its aggregation state

α-突触核蛋白与脂质囊泡的结合模式有两种,取决于其聚集状态。

Högen, Tobias; Levin, Johannes; Schmidt, Felix; Caruana, Mario; Vassallo, Neville; Kretzschmar, Hans; Bötzel, Kai; Kamp, Frits; Giese, Armin

Single-channel electrophysiology reveals a distinct and uniform pore complex formed by α-synuclein oligomers in lipid membranes

单通道电生理学揭示了脂质膜中由α-突触核蛋白寡聚体形成的独特且均匀的孔道复合物。

Schmidt, Felix; Levin, Johannes; Kamp, Frits; Kretzschmar, Hans; Giese, Armin; Bötzel, Kai

Translational repression of the disintegrin and metalloprotease ADAM10 by a stable G-quadruplex secondary structure in its 5'-untranslated region.

5'非翻译区中稳定的G-四链体二级结构抑制解整合素和金属蛋白酶ADAM10的翻译

Lammich Sven, Kamp Frits, Wagner Judith, Nuscher Brigitte, Zilow Sonja, Ludwig Ann-Katrin, Willem Michael, Haass Christian

Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms

倍普地尔和胺碘酮通过不同的机制同时靶向阿尔茨海默病β-分泌酶和γ-分泌酶。

Mitterreiter, Stefan; Page, Richard M; Kamp, Frits; Hopson, Jessika; Winkler, Edith; Ha, Huy-Riem; Hamid, Runa; Herms, Jochen; Mayer, Thomas U; Nelson, Deborah J; Steiner, Harald; Stahl, Tobias; Zeitschel, Ulrike; Rossner, Steffen; Haass, Christian; Lichtenthaler, Stefan F