日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis.

利用 iPSC 衍生神经元进行 CRISPR 筛选揭示了 tau 蛋白稳态的原理。

Samelson Avi J, Ariqat Nabeela, McKetney Justin, Rohanitazangi Gita, Parra Bravo Celeste, Bose Rudra S, Travaglini Kyle J, Lam Victor L, Goodness Darrin, Ta Thomas, Dixon Gary, Marzette Emily, Jin Julianne, Tian Ruilin, Tse Eric, Abskharon Romany, Pan Henry S, Carroll Emma C, Lawrence Rosalie E, Gestwicki Jason E, Rexach Jessica E, Eisenberg David S, Kanaan Nicholas M, Southworth Daniel R, Gross John D, Gan Li, Swaney Danielle L, Kampmann Martin

Extracellular matrix proteolysis maintains synapse plasticity during brain development

细胞外基质蛋白水解在脑发育过程中维持突触可塑性

Nakajo, Haruna; Cao, Ran; Mula, Supriya A; McKetney, Justin; Silva, Nicholas J; Li, Kathy H; Chalkley, Robert J; Randolph, Lisa K; Shah, Muskaan; Rose, Indigo V L; Kampmann, Martin; Swaney, Danielle L; Kirst, Christoph; Molofsky, Anna V

Comparative lipidomics of iPSC-derived microglia protocols reveal lipid droplet and immune differences mediated by media composition.

对 iPSC 衍生的小胶质细胞方案进行比较脂质组学分析,揭示了培养基成分介导的脂滴和免疫差异。

Toda Robert Aiko, McQuade Amanda, Koppes-den Hertog Sascha J, Erlebach Lena, Kronenberg-Versteeg Deborah, Kampmann Martin, Giera Martin, van der Kant Rik

The Hsp40 cochaperone DNAJC7 regulates polyglutamine aggregation and exhibits context-dependent effects on polyglycine aggregation

Hsp40辅助伴侣蛋白DNAJC7调控多聚谷氨酰胺聚集,并对多聚甘氨酸聚集表现出依赖于环境的效应。

Ramani, Biswarathan; Ehsani, Kean; Kampmann, Martin

Multi-omic phenotyping of MAPT V337M neurons reveals early changes in axonogenesis and tau phosphorylation

MAPT V337M神经元的多组学表型分析揭示了轴突发生和tau蛋白磷酸化的早期变化

Mohl, Gregory A; Dixon, Gary; Marzette, Emily; McKetney, Justin; Samelson, Avi J; Serras, Carlota Pereda; Jin, Julianne; Ariqat, Nabeela; Keys, Andrea; Chavira, Cristian; Li, Andrew; Boggess, Steven C; Swaney, Danielle L; Kampmann, Martin

A genetic screen in enteroendocrine cells reveals mechanisms that control protein sensing and GLP-1 release

肠内分泌细胞的基因筛选揭示了控制蛋白质感知和GLP-1释放的机制

Yu, Shenliang; Lee, Yoochae; Boggess, Steven C; Klein, Nicole R; Teyssier, Noam; Kampmann, Martin; Knight, Zachary A

In vivo Proximity & Spatial Proteomics with CRISPR Screening Identify STXBP1 as a Protective Modifier of α-synuclein Toxicity in Dopamine Neurons

利用 CRISPR 筛选技术进行体内邻近性和空间蛋白质组学分析,发现 STXBP1 是多巴胺神经元中 α-突触核蛋白毒性的保护性调节因子。

Shonai, Daichi; Kent, Julie; Okafor, Arinze; Gao, Yudong; Parameswaran, Pooja; Bustamante, Edwin; Ramani, Biswarathan; Diao, Yarui; Kampmann, Martin; Soderblom, Erik; Soderling, Scott

CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes

利用腺相关病毒(AAV)游离体测序技术进行CRISPR筛选(CrAAVe-seq):一种可扩展的细胞类型特异性体内平台,用于揭示神经元必需基因

Ramani, Biswarathan; Rose, Indigo V L; Teyssier, Noam; Pan, Andrew; Danner-Bocks, Spencer; Sanghal, Tanya; Yadanar, Lin; Tian, Ruilin; Ma, Keran; Palop, Jorge J; Kampmann, Martin

β-Amyloid induces microglial expression of GPC4 and APOE leading to increased neuronal tau pathology and toxicity.

β-淀粉样蛋白诱导小胶质细胞表达GPC4和APOE,导致神经元tau蛋白病理和毒性增加

Holmes Brandon B, Weigel Thaddeus K, Chung Jesseca M, Kaufman Sarah K, Apresa Brandon I, Byrnes James R, Kumru Kaan S, Vaquer-Alicea Jaime, Gupta Ankit, Rose Indigo V L, Zhang Yun, Nana Alissa L, Alter Dina, Grinberg Lea T, Spina Salvatore, Leung Kevin K, Miller Bruce L, Condello Carlo, Kampmann Martin, Seeley William W, Coutinho-Budd Jaeda C, Wells James A

A Molecular Glue Approach to Control the Half-Life of CRISPR-Based Technologies

利用分子胶控制CRISPR技术半衰期的方法

Sreekanth, Vedagopuram; Jan, Max; Zhao, Kevin T; Lim, Donghyun; Siriwongsup, Surached; Davis, Jessie R; McConkey, Marie; Kovalcik, Veronica; Barkal, Sam; Law, Benjamin K; Fife, James; Tian, Ruilin; Vinyard, Michael E; Becerra, Basheer; Kampmann, Martin; Sherwood, Richard I; Pinello, Luca; Liu, David R; Ebert, Benjamin L; Choudhary, Amit