日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis.

利用 iPSC 衍生神经元进行 CRISPR 筛选揭示了 tau 蛋白稳态的原理。

Samelson Avi J, Ariqat Nabeela, McKetney Justin, Rohanitazangi Gita, Parra Bravo Celeste, Bose Rudra S, Travaglini Kyle J, Lam Victor L, Goodness Darrin, Ta Thomas, Dixon Gary, Marzette Emily, Jin Julianne, Tian Ruilin, Tse Eric, Abskharon Romany, Pan Henry S, Carroll Emma C, Lawrence Rosalie E, Gestwicki Jason E, Rexach Jessica E, Eisenberg David S, Kanaan Nicholas M, Southworth Daniel R, Gross John D, Gan Li, Swaney Danielle L, Kampmann Martin

Motor, not cognitive, performance relates to amyloid status in normal older adults

在正常老年人中,运动能力而非认知能力与淀粉样蛋白状态相关。

Cook Maher, Amanda; Rose, Savannah; DuBois, Kelly N; Kanaan, Nicholas M; Koeppe, Robert; Bross, Jordan; Flynn, Emma; Murphey, Yi Lu; Persad, Carol C; Giordani, Bruno

Sex-specific effects of acetylation on tauopathy in aging htau mice.

乙酰化对衰老 htau 小鼠 tau 蛋白病变的性别特异性影响。

Sabir Usman, Csubak Bovinari Alistair, Ilchenko Serguei, Ansari Mohammad Yunus, Kanaan Nicholas M, Tsai Tsung-Heng, Srinivasan Dasarathy, Dengler-Crish Christine M, Kasumov Takhar

Evaluation of a panel of plasma biomarkers for Alzheimer's disease in a diverse research cohort

在多元化的研究队列中评估一组用于诊断阿尔茨海默病的血浆生物标志物

DuBois, Kelly N; Pal, Subhamoy; Reader, Jonathan M; Jackman, Brianna; Perkins, Matthew D; Khobeir, Nahla; Bakulski, Kelly M; Heidebrink, Judith; Hampstead, Benjamin M; Morgan, David G; Kanaan, Nicholas M

Pretangle tau pathology accrual in the default mode network during the progression of Alzheimer's disease

阿尔茨海默病进展过程中默认模式网络中tau蛋白病理的累积

Kara, Betul; Kelly, Ian M; Beck, John S; Kuhn, Nathan; Mufson, Elliott J; Vega, Irving E; Kanaan, Nicholas M; Counts, Scott E

PP2A methylesterase, PME-1, and PP2A methyltransferase, LCMT-1, control sensitivity to impairments caused by injury-related oligomeric tau.

PP2A 甲基酯酶 PME-1 和 PP2A 甲基转移酶 LCMT-1 控制着对损伤相关寡聚 tau 引起的损伤的敏感性。

Sundaresh Sowmya N, Vogel Edward W 3rd, Hue Christopher D, Zhang Hong, Staniszewski Anna, Berman Hanna L, Gill Zafar, Asam Kesava, Liang Siqi, Shen Liwei, Gnanaprakash Madhumathi, Acquarone Erica, Masone Antonio, Fà Mauro, Kanaan Nicholas M, Morrison Barclay 3rd, Arancio Ottavio, Nicholls Russell E

Neuronal gene profiling of tau oligomer-bearing cholinergic nucleus basalis neurons during the onset of Alzheimer's disease

阿尔茨海默病发病过程中基底核胆碱能神经元中tau寡聚体携带者的神经元基因谱分析

Kara, Betul; Beck, John S; Fu, Zhen; Hickey, Stephanie L; Kanaan, Nicholas M; Mufson, Elliott J; Ginsberg, Stephen D; Counts, Scott E

Tau oligomers impair memory and synaptic plasticity through the cellular prion protein.

Tau 寡聚体通过细胞朊病毒蛋白损害记忆和突触可塑性

Balducci Claudia, Orsini Franca, Cerovic Milica, Beeg Marten, Rocutto Beatrice, Dacomo Letizia, Masone Antonio, Busani Eleonora, Raimondi Ilaria, Lavigna Giada, Chen Po-Tao, Leva Susanna, Colombo Laura, Zucchelli Chiara, Musco Giovanna, Kanaan Nicholas M, Gobbi Marco, Chiesa Roberto, Fioriti Luana, Forloni Gianluigi

Polyamination with spermidine enhances pathogenic tau conformations while reducing filamentous aggregate formation in vitro.

亚精胺多胺化作用可增强致病性 tau 蛋白的构象,同时减少体外丝状聚集体的形成

Alhadidy Mohammed M, Mueller Rebecca L, Lamp Jared, Kanaan Nicholas M

Seeding Alzheimer's disease-associated tau pathology in MAPT knock-in primary neurons causes early axonopathy and synaptic dysfunction.

在 MAPT 敲入原代神经元中引入与阿尔茨海默病相关的 tau 病理会导致早期轴突病变和突触功能障碍。

Mueller Rebecca L, Combs Benjamin, Kanaan Nicholas M