日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Cholesterol Promotes Lung Adenocarcinoma Brain Metastasis by Stabilizing EGFR Protein to Drive EMT, Metabolic Reprogramming, and Premetastatic Niche Formation

胆固醇通过稳定 EGFR 蛋白促进肺腺癌脑转移，进而驱动 EMT、代谢重编程和转移前微环境形成

期刊:Advanced Science
影响因子:14.1
doi:10.1002/advs.73843
Chen, Ying; Cui, Xiaoteng; Shi, Xinyi; Yang, Xu; Cao, Yujing; Li, Haolin; Zhan, Qi; Wang, Qixue; Li, Ang; Cheng, Qihong; Wang, Yunfei; Zhou, Junhu; Wang, MingJie; Kang, Chunsheng; Liu, Xiaomin
肿瘤
肿瘤免疫
EGF
神经科学
代谢
代谢重编程
EGFR
发表日期：2026
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VITA-GBM: EPIC-0502-driven HIF1α degradation overcomes bevacizumab resistance and synergizes with TMZ in glioblastoma

VITA-GBM：EPIC-0502 驱动的 HIF1α 降解克服了贝伐珠单抗耐药性，并与替莫唑胺在胶质母细胞瘤中产生协同作用

期刊:Neuro-Oncology
影响因子:13.4
doi:10.1093/neuonc/noaf293
Ding, Yaqing; Zhan, Qi; Cui, Longtao; Cui, Xiaoteng; Zhao, Yilin; Wang, Qixue; Hong, Biao; Huang, Yanping; Su, Dongyuan; Cheng, Chunchao; Xu, Hanyi; Liang, Siwen; Zhao, Xun; Liu, Yuhao; Kang, Chunsheng
细胞生物学
发表日期：2026
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PEAKS activation by PROTAC EPIC-0726 potentiates temozolomide in glioblastoma via K63/K48 ubiquitination-dependent ERK/AKT suppression and p21 stabilization

PROTAC EPIC-0726 通过 K63/K48 泛素化依赖的 ERK/AKT 抑制和 p21 稳定增强 PEAKS 激活，从而增强替莫唑胺在胶质母细胞瘤中的疗效。

期刊:Neuro-Oncology
影响因子:13.4
doi:10.1093/neuonc/noaf253
Hong, Biao; Su, Dongyuan; Cui, Xiaoteng; Zhao, Jixing; Wang, Qixue; Zhan, Qi; Yang, Eryan; Yang, Shixue; Ju, Jiasheng; Huang, Yanping; Cheng, Chunchao; Ding, Yaqing; Xu, Hanyi; Cui, Longtao; Zhao, Yilin; Zhao, Xun; Liang, Siwen; Liu, Yuhao; Kang, Chunsheng
AKT
表观遗传
泛素化
细胞生物学
MAPK/ERK
发表日期：2026
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LPC-engineered liposomes activate transcytosis for paclitaxel brain delivery and potentiation of TTFields/TMZ via TALECT regimen in glioblastoma

LPC工程化脂质体通过TALECT方案激活胞吞作用，将紫杉醇递送至脑部，并增强TTFields/TMZ在胶质母细胞瘤中的疗效。

期刊:Theranostics
影响因子:13.3
doi:10.7150/thno.122658
Zhan, Qi; Yi, Kaikai; Yang, Shixue; Hong, Biao; Su, Dongyuan; Zhao, Jixing; Wang, Qixue; Cui, Xiaoteng; Huang, Yanping; Ding, Yaqing; Cheng, Chunchao; Ju, Jiasheng; Kang, Chunsheng
细胞生物学
神经科学
发表日期：2026
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[Retracted] Downregulated microRNA‑200a promotes EMT and tumor growth through the Wnt/β‑catenin pathway by targeting the E‑cadherin repressors ZEB1/ZEB2 in gastric adenocarcinoma

【已撤稿】下调的microRNA-200a通过靶向E-钙黏蛋白抑制因子ZEB1/ZEB2，经由Wnt/β-catenin通路促进胃腺癌中的EMT和肿瘤生长

期刊:Oncology Reports
影响因子:3.9
doi:10.3892/or.2026.9045
Cong, Ningning; Du, Ping; Zhang, Anling; Shen, Fajuan; Su, Juan; Pu, Peiyu; Wang, Tao; Zjang, Jie; Kang, Chunsheng; Zhang, Qingyu
肿瘤
肿瘤免疫
信号转导
Wnt/β-Catenin
EB1
ZEB2
ZEB1
发表日期：2026
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Linagliptin synergizes with cPLA2 inhibition to enhance temozolomide efficacy by interrupting DPP4-mediated EGFR stabilization in glioma.

利格列汀与 cPLA2 抑制剂协同作用，通过干扰 DPP4 介导的 EGFR 在胶质瘤中的稳定作用来增强替莫唑胺的疗效

期刊:Acta Pharmaceutica Sinica B
影响因子:14.6
doi:10.1016/j.apsb.2025.05.012
Su Dongyuan, Hong Biao, Yang Shixue, Zhao Jixing, Cui Xiaoteng, Zhan Qi, Yi Kaikai, Huang Yanping, Ju Jiasheng, Yang Eryan, Wang Qixue, Zhou Junhu, Wang Yunfei, Liu Xing, Kang Chunsheng
肿瘤
胶质瘤
EGFR
肿瘤免疫
发表日期：2025
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CYP3A5 promotes glioblastoma stemness and chemoresistance through fine-tuning NAD(+)/NADH ratio

CYP3A5 通过精细调节 NAD(+)/NADH 比值来促进胶质母细胞瘤干性和化疗耐药性。

期刊:Journal of Experimental & Clinical Cancer Research
影响因子:12.8
doi:10.1186/s13046-024-03254-x
Hu, Wentao; Cui, Xiaoteng; Liu, Hongyu; Li, Ze; Chen, Xu; Wang, Qixue; Zhang, Guolu; Wen, Er; Lan, Jinxin; Chen, Junyi; Liu, Jialin; Kang, Chunsheng; Chen, Ling
细胞生物学
发表日期：2025
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AQB improves carboplatin sensitivity in endometrial cancer through dual DNA repair modulation: suppression of the p21-E2F1-RAD51 and ATF3-HDAC1-BRCA1 signaling

AQB通过双重DNA修复调节提高子宫内膜癌对卡铂的敏感性：抑制p21-E2F1-RAD51和ATF3-HDAC1-BRCA1信号通路

期刊:Cell Death & Disease
影响因子:9.6
doi:10.1038/s41419-025-08287-4
Zheng, Xingyu; Yang, Eryan; Yan, Ye; Zhao, Shuangshuang; Li, Xianxian; Wang, Tianqi; Piao, Yuening; Liu, Wei; Chen, Jiaxin; Wen, Sitong; Gao, Chao; Tian, Wenyan; Xue, Fengxia; Kang, Chunsheng; Wang, Yingmei
肿瘤
HDAC1
子宫内膜癌
肿瘤免疫
信号转导
E2F1
BRCA1
RAD51
发表日期：2025
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A zinc transporter drives glioblastoma progression via extracellular vesicles-reprogrammed microglial plasticity

锌转运蛋白通过细胞外囊泡重编程小胶质细胞可塑性驱动胶质母细胞瘤进展

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2427073122
Zhang, Liyang; Yang, Jingxuan; Zhou, Zhijun; Ren, Yu; Chen, Bo; Tang, Anliu; Zhang, Kailiang; Li, Chuntao; Zhou, Hongshu; Fung, Kar-Ming; Xu, Chao; Kang, Chunsheng; Battiste, James D; Bronze, Michael S; Houchen, Courtney W; Liu, Zhixiong; Dunn, Ian F; Cavenee, Webster K; Li, Min
胶质细胞
囊泡
细胞生物学
发表日期：2025
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[Expression of Concern] miR‑221/222 promote malignant progression of glioma through activation of the Akt pathway

【关注事项】miR-221/222通过激活Akt通路促进胶质瘤的恶性进展。

期刊:International Journal of Oncology
影响因子:4.9
doi:10.3892/ijo.2025.5808
Zhang, Junxia; Han, Lei; Ge, Youlin; Zhou, Xuan; Zhang, Anling; Zhang, Chunzhi; Zhong, Yue; You, Yongping; Pu, Eiyu; Kang, Chunsheng
信号转导
胶质瘤
发表日期：2025
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