日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structural basis for pseudokinase-mediated regulation of GCN2 in the integrated stress response

假激酶介导的GCN2在整合应激反应中的调控的结构基础

Liu, Yixin; Misra, Jagannath; Bhowmik, Debarshi Ryan; O'Boyle, Brady; Staschke, Kirk A; Kannan, Natarajan; Wek, Ronald C; Jura, Natalia

Structural mechanism of anti-MHC-I antibody blocking of inhibitory NK cell receptors in tumor immunity

抗MHC-I抗体阻断肿瘤免疫中抑制性NK细胞受体的结构机制

Jiansheng Jiang #,Abir K Panda #,Kannan Natarajan #,Haotian Lei,Shikha Sharma,Lisa F Boyd,Reanne R Towler,Sruthi Chempati,Javeed Ahmad,Abraham J Morton,Zabrina C Lang,Yi Sun,Nikolaos Sgourakis,Martin Meier-Schellersheim,Rick K Huang,Ethan M Shevach,David H Margulies

Mechanistic basis of teichoic acid transport by a gatekeeper flippase

门控翻转酶介导的磷壁酸转运机制

Cebrero, Gonzalo; Chidananda, Amrutha H; Cester, Eric; Dénéréaz, Julien; Demir, Elif Sena; Mathew, Alen T; Bhowmik, D Ryan; de Capitani, Mario; Reymond, Jean-Louis; Kannan, Natarajan; Avci, Fikri Y; Veening, Jan-Willem; Mehdipour, Ahmad Reza; Perez, Camilo

Antibody-Mediated Inhibition of HLA/LILR Interactions Breaks Innate Immune Tolerance and Induces Antitumor Immunity

抗体介导的HLA/LILR相互作用抑制可打破先天免疫耐受并诱导抗肿瘤免疫

Abir K Panda,Kannan Natarajan,Surajit Sinha,Jiansheng Jiang,Sruthi Chempati,Lisa F Boyd,Priyanka P Desai,Maja Buszko,Yong-Hee Kim,Soha Kazmi,Bryan Fisk,Martha E Teke,Carolina M Larrain,Kirsten Remmert,Andrew M Blakely,Iyadh Douagi,Jonathan M Hernandez,David H Margulies,Ethan M Shevach

An atlas of bacterial serine-threonine kinases reveals functional diversity and key distinctions from eukaryotic kinases

细菌丝氨酸/苏氨酸激酶图谱揭示了其功能多样性以及与真核生物激酶的关键区别

O'Boyle, Brady; Yeung, Wayland; Lu, Jason D; Katiyar, Samiksha; Yaron-Barir, Tomer M; Johnson, Jared L; Cantley, Lewis C; Kannan, Natarajan

Redox regulation and dynamic control of brain-selective kinases BRSK1/2 in the AMPK family through cysteine-based mechanisms.

通过半胱氨酸机制对 AMPK 家族中脑选择性激酶 BRSK1/2 进行氧化还原调节和动态控制

Bendzunas George N, Byrne Dominic P, Shrestha Safal, Daly Leonard A, Oswald Sally O, Katiyar Samiksha, Venkat Aarya, Yeung Wayland, Eyers Claire E, Eyers Patrick A, Kannan Natarajan

Structural and evolutionary insights into understudied bacterial serine-threonine pseudokinase families

对研究不足的细菌丝氨酸/苏氨酸假激酶家族的结构和进化见解

O'Boyle, Brady; Bhowmik, Debarshi Ryan; Eyers, Patrick A; Byrne, Dominic P; Kannan, Natarajan

Deciphering the unique autoregulatory mechanisms and substrate specificity of the understudied DCLK3 kinase linked to neurodegenerative diseases

解析与神经退行性疾病相关的、研究不足的DCLK3激酶独特的自调节机制和底物特异性

Lu, Jason D; Zhao, Peng; Prasad, Anup; Gupta, Neha; Gravel, Nathan; Shidhaye, Tej; Wells, Lance; Katiyar, Samiksha; Kannan, Natarajan

Modeling glycans with AlphaFold 3: capabilities, caveats, and limitations

使用 AlphaFold 3 进行聚糖建模:功能、注意事项和局限性

Huang, Chin; Kannan, Natarajan; Moremen, Kelley W

Identification and classification of ion-channels across the tree of life provide functional insights into understudied CALHM channels

对生命之树中离子通道的鉴定和分类,为深入了解研究不足的CALHM通道提供了重要信息。

Taujale, Rahil; Park, Sung Jin; Gravel, Nathan; Soleymani, Saber; Carter, Rayna; Boyd, Kennady; Keuning, Sarah; Ruan, Zheng; Lü, Wei; Kannan, Natarajan