日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Phase Ib Study of Wnt Inhibitor Ipafricept with Gemcitabine and nab-paclitaxel in Patients with Previously Untreated Stage IV Pancreatic Cancer

一项针对既往未接受治疗的IV期胰腺癌患者的Wnt抑制剂Ipafricept联合吉西他滨和白蛋白紫杉醇的Ib期研究

期刊:Clinical Cancer Research
影响因子:10.2
doi:10.1158/1078-0432.CCR-20-0489
Dotan, Efrat; Cardin, Dana B; Lenz, Heinz-Josef; Messersmith, Wells; O'Neil, Bert; Cohen, Steven J; Denlinger, Crystal S; Shahda, Safi; Astsaturov, Igor; Kapoun, Ann M; Brachmann, Rainer K; Uttamsingh, Shailaja; Stagg, Robert J; Weekes, Colin
胰腺癌
肿瘤
Wnt/β-Catenin
肿瘤免疫
发表日期：2020
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Phase Ib clinical trial of the anti-frizzled antibody vantictumab (OMP-18R5) plus paclitaxel in patients with locally advanced or metastatic HER2-negative breast cancer

抗卷曲抗体vantictumab (OMP-18R5)联合紫杉醇治疗局部晚期或转移性HER2阴性乳腺癌患者的Ib期临床试验

期刊:Breast Cancer Research and Treatment
影响因子:3
doi:10.1007/s10549-020-05817-w
Diamond, Jennifer R; Becerra, Carlos; Richards, Donald; Mita, Alain; Osborne, Cynthia; O'Shaughnessy, Joyce; Zhang, Chun; Henner, Randall; Kapoun, Ann M; Xu, Lu; Stagg, Bob; Uttamsingh, Shailaja; Brachmann, Rainer K; Farooki, Azeez; Mita, Monica
肿瘤
HER2
肿瘤免疫
乳腺癌
OMP
发表日期：2020
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Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs

通过 R-spondin 3 靶向 Wnt 信号通路确定多器官抗纤维化治疗策略

期刊:PLoS One
影响因子:2.9
doi:10.1371/journal.pone.0229445
Mingjun Zhang, Michael Haughey, Nai-Yu Wang, Kate Blease, Ann M Kapoun, Suzana Couto, Igor Belka, Timothy Hoey, Matthew Groza, James Hartke, Brydon Bennett, Jennifer Cain, Austin Gurney, Brent Benish, Paola Castiglioni, Clifton Drew, Jean Lachowicz, Leon Carayannopoulos, Steven D Nathan, Jorg Distle
信号转导
Wnt/β-Catenin
发表日期：2020
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A phase 1b dose escalation study of Wnt pathway inhibitor vantictumab in combination with nab-paclitaxel and gemcitabine in patients with previously untreated metastatic pancreatic cancer

一项针对既往未接受治疗的转移性胰腺癌患者的Wnt通路抑制剂vantictumab联合nab-紫杉醇和吉西他滨的1b期剂量递增研究

期刊:Investigational New Drugs
影响因子:2.7
doi:10.1007/s10637-019-00824-1
Davis, S Lindsey; Cardin, Dana B; Shahda, Safi; Lenz, Heinz-Josef; Dotan, Efrat; O'Neil, Bert H; Kapoun, Ann M; Stagg, Robert J; Berlin, Jordan; Messersmith, Wells A; Cohen, Steven J
肿瘤
肿瘤免疫
信号转导
Wnt/β-Catenin
胰腺癌
发表日期：2020
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A phase 1 dose escalation and expansion study of Tarextumab (OMP-59R5) in patients with solid tumors

Tarextumab (OMP-59R5) 在实体瘤患者中的 1 期剂量递增和扩展研究

期刊:Investigational New Drugs
影响因子:2.7
doi:10.1007/s10637-018-0714-6
Smith, David C; Chugh, Rashmi; Patnaik, Amita; Papadopoulos, Kyriakos P; Wang, Min; Kapoun, Ann M; Xu, Lu; Dupont, Jakob; Stagg, Robert J; Tolcher, Anthony
OMP
发表日期：2019
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Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer

Notch信号通路产生的肿瘤内异质性促进小细胞肺癌的发生发展

期刊:Nature
影响因子:50.5
doi:10.1038/nature22323
Jing Shan Lim ，Alvaro Ibaseta ，Marcus M Fischer ，Belinda Cancilla ，Gilbert O'Young ，Sandra Cristea ，Vincent C Luca ，Dian Yang ，Nadine S Jahchan ，Cécile Hamard ，Martine Antoine ，Marie Wislez ，Christina Kong ，Jennifer Cain ，Yu-Wang Liu ，Ann M Kapoun ，K Christopher Garcia ，Timothy Hoey ，Christopher L Murriel ，Julien Sage
细胞生物学
肺癌
信号转导
肿瘤
肿瘤免疫
Notch
发表日期：2017
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Activating NOTCH1 Mutations Define a Distinct Subgroup of Patients With Adenoid Cystic Carcinoma Who Have Poor Prognosis, Propensity to Bone and Liver Metastasis, and Potential Responsiveness to Notch1 Inhibitors

NOTCH1 激活突变定义了腺样囊性癌患者中的一个独特亚组，该亚组患者预后不良，易发生骨和肝转移，并且可能对 Notch1 抑制剂有反应。

期刊:Journal of Clinical Oncology
影响因子:41.9
doi:10.1200/JCO.2016.67.5264
Ferrarotto, Renata; Mitani, Yoshitsugu; Diao, Lixia; Guijarro, Irene; Wang, Jing; Zweidler-McKay, Patrick; Bell, Diana; William, William N Jr; Glisson, Bonnie S; Wick, Michael J; Kapoun, Ann M; Patnaik, Amita; Eckhardt, Gail; Munster, Pamela; Faoro, Leonardo; Dupont, Jakob; Lee, J Jack; Futreal, Andrew; El-Naggar, Adel K; Heymach, John V
肿瘤
OTC
NOTCH
肿瘤免疫
Notch
Notch1
发表日期：2017
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WNT antagonists exhibit unique combinatorial antitumor activity with taxanes by potentiating mitotic cell death

WNT拮抗剂与紫杉烷类药物联用，通过增强有丝分裂细胞死亡，表现出独特的抗肿瘤活性。

期刊:Science Advances
影响因子:11.7
doi:10.1126/sciadv.1700090
Marcus M Fischer ，Belinda Cancilla ，V Pete Yeung ，Fiore Cattaruzza ，Cecile Chartier ，Christopher L Murriel ，Jennifer Cain ，Raymond Tam ，Chieh-Yang Cheng ，James W Evans ，Gilbert O'Young ，Xiaomei Song ，John Lewicki ，Ann M Kapoun ，Austin Gurney ，Wan-Ching Yen ，Timothy Hoey
细胞生物学
肿瘤
肿瘤免疫
发表日期：2017
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RSPO3 antagonism inhibits growth and tumorigenicity in colorectal tumors harboring common Wnt pathway mutations

RSPO3 拮抗剂可抑制携带常见 Wnt 通路突变的结肠直肠肿瘤的生长和致瘤性

期刊:Scientific Reports
影响因子:3.8
doi:10.1038/s41598-017-15704-y
Marcus M Fischer, V Pete Yeung, Fiore Cattaruzza, Rajaa Hussein, Wan-Ching Yen, Christopher Murriel, James W Evans, Gilbert O'Young, Alayne L Brunner, Min Wang, Jennifer Cain, Belinda Cancilla, Ann Kapoun, Timothy Hoey
肿瘤
Wnt/β-Catenin
发表日期：2017
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Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types

肿瘤衍生的 R-Spondin 治疗靶向减弱多种癌症类型的 β-Catenin 信号传导和肿瘤发生

期刊:Cancer Research
影响因子:12.5
doi:10.1158/0008-5472.CAN-15-0561
Cecile Chartier, Janak Raval, Fumiko Axelrod, Chris Bond, Jennifer Cain, Cristina Dee-Hoskins, Shirley Ma, Marcus M Fischer, Jalpa Shah, Jie Wei, May Ji, Andrew Lam, Michelle Stroud, Wan-Ching Yen, Pete Yeung, Belinda Cancilla, Gilbert O'Young, Min Wang, Ann M Kapoun, John Lewicki, Timothy Hoey, Aus
信号转导
肿瘤
Wnt/β-Catenin
发表日期：2016
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