日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Synthesis, Experimental and Computational Evaluation of SERAAK1 as a 5-HT(2A) Receptor Ligand

SERAAK1作为5-HT(2A)受体配体的合成、实验和计算评价

Zięba, Agata; Kędzierska, Ewa; Jastrzębski, Michał K; Karcz, Tadeusz; Olejarz-Maciej, Agnieszka; Sumara, Agata; Laitinen, Tuomo; Wróbel, Tomasz M; Fornal, Emilia; Castro, Marián; Kaczor, Agnieszka A

SERAAK2 as a Serotonin Receptor Ligand: Structural and Pharmacological In Vitro and In Vivo Evaluation

SERAAK2 作为血清素受体配体:体外和体内结构及药理学评价

Kaczor, Agnieszka A; Zięba, Agata; Karcz, Tadeusz; Jastrzębski, Michał K; Szczepańska, Katarzyna; Laitinen, Tuomo; Castro, Marián; Kędzierska, Ewa

Procognitive Potential of Neuroprotective Triazine 5-HT(6) Receptor Antagonists Tested on Chronic Activity In Vivo in Rats: Computer-Aided Insight into the Role of Chalcogen-Differences on the Pharmacological Profile.

在大鼠体内慢性活动中测试神经保护性三嗪 5-HT(6) 受体拮抗剂的促认知潜力:计算机辅助深入了解硫族元素差异对药理学特征的作用

Jastrzębska-Więsek Magdalena, Garbo Sabrina, Cios Agnieszka, Wilczyńska-Zawal Natalia, Partyka Anna, Honkisz-Orzechowska Ewelina, Å»esławska Ewa, Handzlik Jarosław, Mordyl Barbara, Głuch-Lutwin Monika, Raucci Alessia, Hittinger Marius, Starek Małgorzata, DÄ browska Monika, Nitek Wojciech, Karcz Tadeusz, Skórkowska Alicja, Gdula-Argasińska Joanna, Czarnota-Łydka Kinga, Pyka Patryk, Szymańska Ewa, Kucwaj-Brysz Katarzyna, Zwergel Clemens, Wesołowska Anna, Battistelli Cecilia, Handzlik Jadwiga

P2Y(14) Receptor Antagonists: Piperidine Bioisosteres and Mutagenesis-Supported Molecular Modeling

P2Y(14)受体拮抗剂:哌啶生物等排体和诱变支持的分子建模

Pramanik, Asmita; Wen, Zhiwei; Pavan, Matteo; Kurma, Siva Hariprasad; Karcz, Tadeusz; Lewicki, Sarah A; Liu, Naili; Demby, Tamar; Gavrilova, Oksana; Oliva, Paola; Erlitz, Katharina S; Junker, Anna; Jung, Young-Hwan; Chen, Zhoumou; Salvemini, Daniela; Kousouros, Joseph; Gao, Zhan-Guo; Fay, Jonathan F; Jacobson, Kenneth A

Funnel metadynamics and behavioral studies reveal complex effect of D2AAK1 ligand on anxiety-like processes

漏斗元动力学和行为学研究揭示了D2AAK1配体对焦虑样过程的复杂影响

Bartuzi, Damian; Kędzierska, Ewa; Targowska-Duda, Katarzyna M; Koszła, Oliwia; Wróbel, Tomasz M; Jademyr, Simon; Karcz, Tadeusz; Szczepańska, Katarzyna; Stępnicki, Piotr; Wronikowska-Denysiuk, Olga; Biała, Grażyna; Handzlik, Jadwiga; Kristensen, Jesper L; Poso, Antti; Kaczor, Agnieszka A

Effects of Purinergic Receptor Deletion or Pharmacologic Modulation on Pulmonary Inflammation in Mice

嘌呤能受体缺失或药物调节对小鼠肺部炎症的影响

Whitehead, Gregory S; Karcz, Tadeusz P; Tosh, Dilip K; Jung, Young-Hwan; Wen, Zhiwei; Campbell, Ryan G; Gopinatth, Varun; Gao, Zhan-Guo; Jacobson, Kenneth A; Cook, Donald N

Structure-Activity Relationship of Heterocyclic P2Y(14) Receptor Antagonists: Removal of the Zwitterionic Character with Piperidine Bioisosteres

杂环P2Y(14)受体拮抗剂的构效关系:哌啶生物等排体消除两性离子特性

Jung, Young-Hwan; Salmaso, Veronica; Wen, Zhiwei; Bennett, John M; Phung, Ngan B; Lieberman, David I; Gopinatth, Varun; Randle, John C R; Chen, Zhoumou; Salvemini, Daniela; Karcz, Tadeusz P; Cook, Donald N; Jacobson, Kenneth A

Adipocyte P2Y14 receptors play a key role in regulating whole-body glucose and lipid homeostasis

脂肪细胞P2Y14受体在调节全身葡萄糖和脂质稳态中起关键作用

Jain, Shanu; Pydi, Sai P; Jung, Young-Hwan; Scortichini, Mirko; Kesner, Efrat L; Karcz, Tadeusz P; Cook, Donald N; Gavrilova, Oksana; Wess, Jürgen; Jacobson, Kenneth A

Exploration of Alternative Scaffolds for P2Y(14) Receptor Antagonists Containing a Biaryl Core

探索含联芳基核心的P2Y(14)受体拮抗剂的替代骨架

Jung, Young-Hwan; Yu, Jinha; Wen, Zhiwei; Salmaso, Veronica; Karcz, Tadeusz P; Phung, Ngan B; Chen, Zhoumou; Duca, Sierra; Bennett, John M; Dudas, Steven; Salvemini, Daniela; Gao, Zhan-Guo; Cook, Donald N; Jacobson, Kenneth A

Molecular mechanism of action and safety of 5-(3-chlorophenyl)-4-hexyl-2,4-dihydro-3H-1,2,4-triazole-3-thione - a novel anticonvulsant drug candidate

5-(3-氯苯基)-4-己基-2,4-二氢-3H-1,2,4-三唑-3-硫酮——一种新型抗惊厥候选药物的分子作用机制和安全性

Kaproń, Barbara; Łuszczki, Jarogniew; Paneth, Agata; Wujec, Monika; Siwek, Agata; Karcz, Tadeusz; Mordyl, Barbara; Głuch-Lutwin, Monika; Gryboś, Anna; Nowak, Gabriel; Pająk, Karolina; Jóźwiak, Krzysztof; Tomczykowski, Adam; Plech, Tomasz