Age-Related Increases in PDE11A4 Protein Expression Trigger Liquid-Liquid Phase Separation (LLPS) of the Enzyme That Can Be Reversed by PDE11A4 Small Molecule Inhibitors.
与年龄相关的 PDE11A4 蛋白表达增加会引发该酶的液-液相分离 (LLPS),而 PDE11A4 小分子抑制剂可以逆转这一现象
期刊:Cells
影响因子:5.2
doi:10.3390/cells14120897
Amurrio Elvis, Patel Janvi H, Danaher Marie, Goodwin Madison, Kargbo Porschderek, Klimentova Eliska, Lin Sonia, Kelly Michy P