日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease

通过筛选 nsp14/nsp10 核酸外切酶的小分子抑制剂来鉴定 SARS-CoV-2 抗病毒化合物

Berta Canal #, Allison W McClure #, Joseph F Curran #, Mary Wu, Rachel Ulferts, Florian Weissmann, Jingkun Zeng, Agustina P Bertolin, Jennifer C Milligan, Souradeep Basu, Lucy S Drury, Tom D Deegan, Ryo Fujisawa, Emma L Roberts, Clovis Basier, Karim Labib, Rupert Beale, Michael Howell, John F X Diff

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease

通过筛选 Nsp3 木瓜蛋白酶样蛋白酶的小分子抑制剂来鉴定 SARS-CoV-2 抗病毒化合物

Chew Theng Lim #, Kang Wei Tan #, Mary Wu, Rachel Ulferts, Lee A Armstrong, Eiko Ozono, Lucy S Drury, Jennifer C Milligan, Theresa U Zeisner, Jingkun Zeng, Florian Weissmann, Berta Canal, Ganka Bineva-Todd, Michael Howell, Nicola O'Reilly, Rupert Beale, Yogesh Kulathu, Karim Labib, John F X Diffley

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease

通过筛选 nsp15 内切核糖核酸酶的小分子抑制剂来鉴定 SARS-CoV-2 抗病毒化合物

Berta Canal #, Ryo Fujisawa #, Allison W McClure #, Tom D Deegan #, Mary Wu, Rachel Ulferts, Florian Weissmann, Lucy S Drury, Agustina P Bertolin, Jingkun Zeng, Rupert Beale, Michael Howell, Karim Labib, John F X Diffley

CMG helicase disassembly is controlled by replication fork DNA, replisome components and a ubiquitin threshold

CMG 解旋酶的拆卸由复制叉 DNA、复制体成分和泛素阈值控制

Tom D Deegan, Progya P Mukherjee #, Ryo Fujisawa #, Cristian Polo Rivera #, Karim Labib

Mitotic CDK Promotes Replisome Disassembly, Fork Breakage, and Complex DNA Rearrangements

有丝分裂 CDK 促进复制体解体、叉断裂和复杂的 DNA 重排

Lin Deng, R Alex Wu, Remi Sonneville, Olga V Kochenova, Karim Labib, David Pellman, Johannes C Walter

TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication

TRAIP 在 DNA 复制不完全的位点驱动复制体的拆卸和有丝分裂 DNA 修复合成

Remi Sonneville #, Rahul Bhowmick #, Saskia Hoffmann, Niels Mailand, Ian D Hickson, Karim Labib

The Mcm2-Ctf4-Polα Axis Facilitates Parental Histone H3-H4 Transfer to Lagging Strands

Mcm2-Ctf4-Polα 轴促进亲本组蛋白 H3-H4 转移到滞后链

Haiyun Gan, Albert Serra-Cardona, Xu Hua, Hui Zhou, Karim Labib, Chuanhe Yu, Zhiguo Zhang

Histone H2A-H2B binding by Pol α in the eukaryotic replisome contributes to the maintenance of repressive chromatin

真核复制体中组蛋白H2A-H2B与Polα的结合有助于抑制性染色质的维持

Cecile Evrin, Joseph D Maman, Aurora Diamante, Luca Pellegrini, Karim Labib

CUL-2LRR-1 and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis

CUL-2LRR-1 和 UBXN-3 在 DNA 复制终止和有丝分裂期间驱动复制体分解

Remi Sonneville, Sara Priego Moreno, Axel Knebel, Clare Johnson, C James Hastie, Anton Gartner, Agnieszka Gambus, Karim Labib

The Replisome-Coupled E3 Ubiquitin Ligase Rtt101Mms22 Counteracts Mrc1 Function to Tolerate Genotoxic Stress

复制体偶联的 E3 泛素连接酶 Rtt101Mms22 抵消 Mrc1 功能以耐受基因毒性应激

Raymond Buser, Vanessa Kellner, Andre Melnik, Caroline Wilson-Zbinden, René Schellhaas, Lisa Kastner, Wojciech Piwko, Martina Dees, Paola Picotti, Marija Maric, Karim Labib, Brian Luke, Matthias Peter