日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Transposable elements as novel therapeutic targets for PARPi-induced synthetic lethality in PcG-mutated blood cancer

转座因子作为PARPi诱导的PcG突变血癌合成致死性的新型治疗靶点

Zeisig, Bernd B; Tsai, Chiou-Tsun; Virely, Clemence; Fung, Tsz Kan; Akin, Ali Tuğrul; Troadec, Estelle; Jiao, Bo; Thompson, I Richard; Lau, Priscilla Nga Ieng; Li, Nanjun; Charalambous, Andriani; Bomfim, Larissa; Lynch, Jennifer; Georgiou, Athina; Hoogeboom, Robbert; Lynn, Claire; Zhang, Si-Yi; Patten, Piers E M; Fisher, Cynthia L; Schuh, Anna; Ogawa, Seishi; Mufti, Ghulam; Karimi, Mohammad M; So, Chi Wai Eric

Clinical response to azacitidine in MDS is associated with distinct DNA methylation changes in HSPCs.

MDS 对阿扎胞苷的临床反应与 HSPC 中独特的 DNA 甲基化变化有关

Thoms Julie A I, Yan Feng, Hampton Henry R, Davidson Sarah, Joshi Swapna, Saw Jesslyn, Sarowar Chowdhury H, Lim Xin Ying, Nunez Andrea C, Kakadia Purvi M, Bhuyan Golam Sarower, Zou Xiaoheng, Nguyen Mary, Ghodousi Elaheh S, Koch Forrest C, Vafaee Fatemeh, Thompson I Richard, Karimi Mohammad M, Pickford Russell, Raftery Mark J, Hough Sally, Buckland Griselda, Bailey Michelle, Ghodke Yuvaraj, Absar Noorul, Vaughan Lachlin, Pasalic Leonardo, Fong Chun Y, Kenealy Melita, Hiwase Devendra K, Stoddart Rohanna I, Mohammed Soma, Lee Linda, Passam Freda H, Larsen Stephen R, Spring Kevin J, Skarratt Kristen K, Rebeiro Patricia, Presgrave Peter, Stevenson William S, Ling Silvia, Tiley Campbell, Fuller Stephen J, Roncolato Fernando, Enjeti Anoop K, Hoenemann Dirk, Lemech Charlotte, Jolly Christopher J, Bohlander Stefan K, Curtis David J, Wong Jason W H, Unnikrishnan Ashwin, Hertzberg Mark, Olivier Jake, Polizzotto Mark N, Pimanda John E

Identification of novel myelodysplastic syndromes prognostic subgroups by integration of inflammation, cell-type composition, and immune signatures in the bone marrow

通过整合骨髓中的炎症、细胞类型组成和免疫特征,鉴定新的骨髓增生异常综合征预后亚组

Gerlevik, Sila; Seymen, Nogayhan; Hama, Shan; Mumtaz, Warisha; Thompson, I Richard; Jalili, Seyed R; Kaya, Deniz E; Iacoangeli, Alfredo; Pellagatti, Andrea; Boultwood, Jacqueline; Napolitani, Giorgio; Mufti, Ghulam J; Karimi, Mohammad M

Expression of most retrotransposons in human blood correlates with biological aging

大多数逆转录转座子在人类血液中的表达与生物衰老相关。

Tsai, Yi-Ting; Seymen, Nogayhan; Thompson, I Richard; Zou, Xinchen; Mumtaz, Warisha; Gerlevik, Sila; Mufti, Ghulam J; Karimi, Mohammad M

ModEx: a general purpose computer model exploration system

ModEx:通用计算机模型探索系统

Younesy, Hamid; Pober, Joseph; Möller, Torsten; Karimi, Mohammad M

Spontaneous Cholemia in C57BL/6 Mice Predisposes to Liver Cancer in NASH

C57BL/6小鼠自发性胆汁酸血症易导致非酒精性脂肪性肝炎(NASH)患者发生肝癌。

Gallage, Suchira; Ali, Adnan; Barragan Avila, Jose Efren; Herebian, Diran; Karimi, Mohammad M; Irvine, Elaine E; McHugh, Domhnall; Schneider, Anne T; Vucur, Mihael; Keitel, Verena; Gil, Jesús; Withers, Dominic J; Luedde, Tom; Heikenwalder, Mathias

iNucs: inter-nucleosome interactions

iNucs:核小体间相互作用

Oveisi, Mehrdad; Shukla, Manu; Seymen, Nogayhan; Ohno, Masae; Taniguchi, Yuichi; Nahata, Sunil; Loos, Remco; Mufti, Ghulam J; Allshire, Robin C; Dimitrov, Stefan; Karimi, Mohammad M

Evolution of an Amniote-Specific Mechanism for Modulating Ubiquitin Signaling via Phosphoregulation of the E2 Enzyme UBE2D3

羊膜动物特有的泛素信号传导调控机制的进化:通过E2酶UBE2D3的磷酸化调控

Roman-Trufero, Monica; Ito, Constance M; Pedebos, Conrado; Magdalou, Indiana; Wang, Yi-Fang; Karimi, Mohammad M; Moyon, Benjamin; Webster, Zoe; di Gregorio, Aida; Azuara, Veronique; Khalid, Syma; Speck, Christian; Rodriguez, Tristan; Dillon, Niall

Development and application of an integrated allele-specific pipeline for methylomic and epigenomic analysis (MEA)

开发和应用用于甲基化组学和表观基因组学分析(MEA)的集成等位基因特异性流程

Richard Albert, Julien; Koike, Tasuku; Younesy, Hamid; Thompson, Richard; Bogutz, Aaron B; Karimi, Mohammad M; Lorincz, Matthew C

ChAsE: chromatin analysis and exploration tool

ChAsE:染色质分析和探索工具

Younesy, Hamid; Nielsen, Cydney B; Lorincz, Matthew C; Jones, Steven J M; Karimi, Mohammad M; Möller, Torsten