日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Novel Allosteric Mechanism of Dual p53/MDM2 and p53/MDM4 Inhibition by a Small Molecule

小分子双重抑制 p53/MDM2 和 p53/MDM4 的新型变构机制

Vera V Grinkevich, Aparna Vema, Karin Fawkner, Natalia Issaeva, Virginia Andreotti, Eleanor R Dickinson, Elisabeth Hedström, Clemens Spinnler, Alberto Inga, Lars-Gunnar Larsson, Anders Karlén, Margareta Wilhelm, Perdita E Barran, Andrei L Okorokov, Galina Selivanova, Joanna E Zawacka-Pankau

MYCMI-7: A Small MYC-Binding Compound that Inhibits MYC: MAX Interaction and Tumor Growth in a MYC-Dependent Manner

MYCMI-7:一种小型 MYC 结合化合物,以 MYC 依赖的方式抑制 MYC:MAX 相互作用和肿瘤生长

Alina Castell, Qinzi Yan, Karin Fawkner, Wesam Bazzar, Fan Zhang, Malin Wickström, Mohammad Alzrigat, Marcela Franco, Cecilia Krona, Donald P Cameron, Cecilia Dyberg, Thale Kristin Olsen, Vasiliki Verschut, Linnéa Schmidt, Sheryl Y Lim, Loay Mahmoud, Per Hydbring, Sören Lehmann, Laura Baranello, Sve

A selective high affinity MYC-binding compound inhibits MYC:MAX interaction and MYC-dependent tumor cell proliferation

选择性高亲和力 MYC 结合化合物可抑制 MYC:MAX 相互作用和 MYC 依赖性肿瘤细胞增殖

Alina Castell, Qinzi Yan, Karin Fawkner, Per Hydbring, Fan Zhang, Vasiliki Verschut, Marcela Franco, Siti Mariam Zakaria, Wesam Bazzar, Jacob Goodwin, Giovanna Zinzalla, Lars-Gunnar Larsson