日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

P21-positive senescent stromal cells promote prostate cancer immune suppression and progression that can be reversed by senolytic therapy

P21阳性衰老基质细胞促进前列腺癌免疫抑制和进展,而衰老细胞清除疗法可以逆转这一过程。

Lin Zhou ,Kelly D DeMarco ,Katherine C Murphy ,Zhenpeng Wu ,Jinping Li ,Calvin Johnson ,Bin Liu ,Hadiya K Giwa ,Boyang Ma ,Nikita Bhalerao ,Junhui Li ,Zhong Jiang ,Shi Bai ,Chaitanya N Parikh ,Tianyi Ye ,Karl Simin ,Lihua J Zhu ,Jason R Pitarresi ,Hong Wu ,Marcus Ruscetti

Targeting the GPI transamidase subunit GPAA1 abrogates the CD24 immune checkpoint in ovarian cancer

靶向 GPI 转酰胺酶亚基 GPAA1 可消除卵巢癌中的 CD24 免疫检查点

Alok K Mishra, Tianyi Ye, Shahid Banday, Ritesh P Thakare, Chinh Tran-To Su, Ngoc N H Pham, Amjad Ali, Ankur Kulshreshtha, Shreya Roy Chowdhury, Tessa M Simone, Kai Hu, Lihua Julie Zhu, Birgit Eisenhaber, Sara K Deibler, Karl Simin, Paul R Thompson, Michelle A Kelliher, Frank Eisenhaber, Sunil K Mal

MYC and p53 alterations cooperate through VEGF signaling to repress cytotoxic T cell and immunotherapy responses in prostate cancer

MYC 和 p53 变异通过 VEGF 信号传导协同抑制前列腺癌中的细胞毒性 T 细胞和免疫治疗反应

Katherine C Murphy, Kelly D DeMarco, Lin Zhou, Yvette Lopez-Diaz, Yu-Jui Ho, Junhui Li, Shi Bai, Karl Simin, Lihua Julie Zhu, Arthur M Mercurio, Marcus Ruscetti

Disruption of sugar nucleotide clearance is a therapeutic vulnerability of cancer cells

糖核苷酸清除的破坏是癌细胞治疗的弱点

Mihir B Doshi, Namgyu Lee, Tenzin Tseyang, Olga Ponomarova, Hira Lal Goel, Meghan Spears, Rui Li, Lihua Julie Zhu, Christopher Ashwood, Karl Simin, Cholsoon Jang, Arthur M Mercurio, Albertha J M Walhout, Jessica B Spinelli, Dohoon Kim

EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype to potentiate pancreatic cancer immune surveillance

EZH2 抑制重塑炎症衰老相关分泌表型,增强胰腺癌免疫监视

Loretah Chibaya, Katherine C Murphy, Kelly D DeMarco, Sneha Gopalan, Haibo Liu, Chaitanya N Parikh, Yvette Lopez-Diaz, Melissa Faulkner, Junhui Li, John P Morris 4th, Yu-Jui Ho, Sachliv K Chana, Janelle Simon, Wei Luan, Amanda Kulick, Elisa de Stanchina, Karl Simin, Lihua Julie Zhu, Thomas G Fazzio,

De novo sphingolipid biosynthesis necessitates detoxification in cancer cells

癌细胞中从头合成鞘脂需要解毒作用。

Meghan E Spears ,Namgyu Lee ,Sunyoung Hwang ,Sung Jin Park ,Anne E Carlisle ,Rui Li ,Mihir B Doshi ,Aaron M Armando ,Jenny Gao ,Karl Simin ,Lihua Julie Zhu ,Paul L Greer ,Oswald Quehenberger ,Eduardo M Torres ,Dohoon Kim

Selenium detoxification is required for cancer-cell survival

硒解毒是癌细胞存活的必要条件

Anne E Carlisle #, Namgyu Lee #, Asia N Matthew-Onabanjo, Meghan E Spears, Sung Jin Park, Daniel Youkana, Mihir B Doshi, Austin Peppers, Rui Li, Alexander B Joseph, Miles Smith, Karl Simin, Lihua Julie Zhu, Paul L Greer, Leslie M Shaw, Dohoon Kim

Evidence for phenotypic plasticity in aggressive triple-negative breast cancer: human biology is recapitulated by a novel model system

侵袭性三阴性乳腺癌表型可塑性的证据:一种新的模型系统重现了人类生物学

Nicholas C D'Amato, Julie H Ostrander, Michelle L Bowie, Christopher Sistrunk, Alexander Borowsky, Robert D Cardiff, Katie Bell, Lawrence J T Young, Karl Simin, Robin E Bachelder, Jeff Delrow, Alyssa Dawson, Lisa D Yee, Krzysztof Mrózek, Timothy M Clay, Takuya Osada, Victoria L Seewaldt