日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Longitudinal T-Cell Phenotypic Dynamics During Sustained Antiretroviral Therapy in People With HIV

HIV感染者持续抗逆转录病毒治疗期间T细胞表型纵向动态变化

Vanpouille, Christophe; Wells, Alan; DeGruttola, Victor; Lynch, Miranda; Zhang, Xinlian; Tu, Xin M; Chaillon, Antoine; Woodworth, Brendon; Gaitan, Noah; Rawlings, Stephen A; Landay, Alan; Weber, Kathleen M; Scully, Eileen P; Karn, Jonathan; Gianella, Sara

RasGRP1 agonists stimulate P-TEFb biogenesis via MEK-ERK-mTORC1 signaling to reverse HIV latency with minimal CD4 downregulation

RasGRP1激动剂通过MEK-ERK-mTORC1信号通路刺激P-TEFb生物合成,从而逆转HIV潜伏,且CD4下调程度极低。

Mbonye, Uri; Bellomo, Ana; Elhalem, Eleonora; Donadio, Lucia Gandolfi; Yang, Muda; Donner, Amie; Comin, Maria Julieta; Karn, Jonathan

Reduction of the HIV-1 reservoir in T cells from people with HIV-1 on suppressive antiretroviral therapy using expanded natural killer cells

利用扩增的自然杀伤细胞减少接受抑制性抗逆转录病毒疗法的 HIV-1 感染者 T 细胞中的 HIV-1 病毒库

Checkley, Mary Ann; Luttge, Benjamin G; Cameron, Cheryl M; Leskov, Konstantin S; Dobrowolski, Curtis; Wald, David N; McMahon, Deborah; Haidar, Ghady; Sobolewski, Michele D; Enick, P Nathan; Cyktor, Joshua; Mellors, John W; Karn, Jonathan

Non-neutralizing antibodies against SARS-CoV-2 nucleocapsid protein mediate variant transcendent antibody-dependent cellular cytotoxicity

针对SARS-CoV-2核衣壳蛋白的非中和抗体介导变异型超抗体依赖性细胞毒性

Osuagwu, Anthonia E; Payne, Michael; Bosch, Jürgen; Mbonye, Uri; Nguyen, Kien; Karn, Jonathan; Bruchez, Anna; King, Christopher L

HIV infection in microglia leads to senescence, triggering activation of neurotoxicity pathways

HIV感染小胶质细胞会导致其衰老,进而激活神经毒性通路。

Mason, Sara J; Sreeram, Sheetal; Niazi, Farshad; Leskov, Konstantin; Levine, Alan D; Karn, Jonathan; Valadkhan, Saba

Interleukin-2 is a potent latency reversal agent in people with treated HIV-1

白细胞介素-2是治疗后HIV-1感染者体内一种有效的潜伏期逆转剂。

Freeman, Michael L; Clagett, Brian M; Leskov, Konstantin; Moisi, Daniela; Yendewa, George A; Sieg, Scott F; Laird, Gregory M; Karn, Jonathan; Jacobson, Jeffrey M; Rodriguez, Benigno; Lederman, Michael M

Cytokine trajectory over time in men and women with HIV on long-term antiretroviral therapy

长期接受抗逆转录病毒治疗的HIV感染男性和女性的细胞因子随时间变化的轨迹

Vanpouille, Christophe; Wells, Alan; DeGruttola, Victor; Lynch, Miranda; Zhang, Xinlian; Fitzgerald, Wendy; Tu, Xin; Chaillon, Antoine; Landay, Alan; Weber, Kathleen; Scully, Eileen; Karn, Jonathan; Gianella, Sara

The sounds of silencing: dynamic epigenetic control of HIV latency

沉默之声:HIV潜伏期的动态表观遗传调控

Nguyen, Kien; Karn, Jonathan

Pre-exposure immunohematologic features of heart failure associate with COVID-19 mortality

心力衰竭患者在感染新冠病毒前已存在的免疫血液学特征与新冠病毒感染死亡率相关

Zidar, David A; Wilson, Brigid M; Al-Kindi, Sadeer G; Sweet, David; Juchnowski, Steven; Huntington, Lauren; Shive, Carey; Bosch, Jürgen; King, Christopher; Karn, Jonathan; Chung, Mina K; Gillombardo, Carl B; Karnib, Mohammad; Sundaram, Varun; Parikh, Sahil A; Jain, Mukesh; Gunzler, Douglas D; Skarbinski, Jacek; Tang, W H Wilson; Anthony, Donald D; Chan, Timothy A; Dalton, Jarrod E

Direct Analysis of HIV mRNA m(6)A Methylation by Nanopore Sequencing

利用纳米孔测序直接分析HIV mRNA m(6)A甲基化

Honeycutt, Ethan; Kizito, Fredrick; Karn, Jonathan; Sweet, Thomas