日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Systematic optimization of prime editing for the efficient functional correction of CFTR F508del in human airway epithelial cells

系统优化主编辑策略,以实现人呼吸道上皮细胞中CFTR F508del突变的有效功能性矫正

Sousa, Alexander A; Hemez, Colin; Lei, Lei; Traore, Soumba; Kulhankova, Katarina; Newby, Gregory A; Doman, Jordan L; Oye, Keyede; Pandey, Smriti; Karp, Philip H; McCray, Paul B Jr; Liu, David R

Mitochondrial uncoupling proteins protect human airway epithelial ciliated cells from oxidative damage

线粒体解偶联蛋白保护人呼吸道上皮纤毛细胞免受氧化损伤

Jain, Akansha; Kim, Bo Ram; Yu, Wenjie; Moninger, Thomas O; Karp, Philip H; Wagner, Brett A; Welsh, Michael J

WNK Inhibition Increases Surface Liquid pH and Host Defense in Cystic Fibrosis Airway Epithelia

WNK抑制可增加囊性纤维化气道上皮细胞表面液pH值并增强宿主防御能力。

Rehman, Tayyab; Karp, Philip H; Thurman, Andrew L; Mather, Steven E; Jain, Akansha; Cooney, Ashley L; Sinn, Patrick L; Pezzulo, Alejandro A; Duffey, Michael E; Welsh, Michael J

Heterogeneous expression of the SARS-Coronavirus-2 receptor ACE2 in the human respiratory tract

SARS冠状病毒2受体ACE2在人类呼吸道中的异质性表达

Ortiz, Miguel E; Thurman, Andrew; Pezzulo, Alejandro A; Leidinger, Mariah R; Klesney-Tait, Julia A; Karp, Philip H; Tan, Ping; Wohlford-Lenane, Christine; McCray, Paul B Jr; Meyerholz, David K

Motile cilia of human airway epithelia contain hedgehog signaling components that mediate noncanonical hedgehog signaling

人类呼吸道上皮细胞的运动纤毛含有 Hedgehog 信号通路成分,可介导非经典 Hedgehog 信号通路。

Mao, Suifang; Shah, Alok S; Moninger, Thomas O; Ostedgaard, Lynda S; Lu, Lin; Tang, Xiao Xiao; Thornell, Ian M; Reznikov, Leah R; Ernst, Sarah E; Karp, Philip H; Tan, Ping; Keshavjee, Shaf; Abou Alaiwa, Mahmoud H; Welsh, Michael J

Lack of cystic fibrosis transmembrane conductance regulator disrupts fetal airway development in pigs.

囊性纤维化跨膜传导调节因子缺乏会破坏猪胎儿气道发育

Meyerholz David K, Stoltz David A, Gansemer Nick D, Ernst Sarah E, Cook Daniel P, Strub Matthew D, LeClair Erica N, Barker Carrie K, Adam Ryan J, Leidinger Mariah R, Gibson-Corley Katherine N, Karp Philip H, Welsh Michael J, McCray Paul B Jr

Nominal carbonic anhydrase activity minimizes airway-surface liquid pH changes during breathing

碳酸酐酶的正常活性可最大限度地减少呼吸过程中气道表面液体的pH值变化

Thornell, Ian M; Li, Xiaopeng; Tang, Xiao Xiao; Brommel, Christian M; Karp, Philip H; Welsh, Michael J; Zabner, Joseph

Acidic pH increases airway surface liquid viscosity in cystic fibrosis.

囊性纤维化患者的气道表面液体粘度因酸性pH值升高而增加

Tang Xiao Xiao, Ostedgaard Lynda S, Hoegger Mark J, Moninger Thomas O, Karp Philip H, McMenimen James D, Choudhury Biswa, Varki Ajit, Stoltz David A, Welsh Michael J

Medical reversal of chronic sinusitis in a cystic fibrosis patient with ivacaftor

伊伐卡托治疗囊性纤维化患者的慢性鼻窦炎逆转

Chang, Eugene H; Tang, Xiao Xiao; Shah, Viral S; Launspach, Janice L; Ernst, Sarah E; Hilkin, Brieanna; Karp, Philip H; Abou Alaiwa, Mahmoud H; Graham, Scott M; Hornick, Douglas B; Welsh, Michael J; Stoltz, David A; Zabner, Joseph

Chemosensory functions for pulmonary neuroendocrine cells

肺神经内分泌细胞的化学感受功能

Gu, Xiaoling; Karp, Philip H; Brody, Steven L; Pierce, Richard A; Welsh, Michael J; Holtzman, Michael J; Ben-Shahar, Yehuda