日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Bacterial colonization of tumors drives immune activation and checkpoint blockade efficacy

肿瘤的细菌定植会激活免疫反应并增强免疫检查点阻断的疗效。

Rolig, Annah S; Ziglari, Tahereh; McGee, Grace Helen; Kasiewicz, Melissa J; Kolbaba, Kenna; Simons, Noah D; Pucilowska, Joanna; Sfanos, Karen; Redmond, William L

The response to anti-PD-1 and anti-LAG-3 checkpoint blockade is associated with regulatory T cell reprogramming

抗PD-1和抗LAG-3检查点阻断疗法的疗效与调节性T细胞重编程有关。

Rolig, Annah S; Peng, Xiyu; Sturgill, Elizabeth R; Holay, Nisha; Kasiewicz, Melissa; Mick, Courtney; Mcgee, Grace Helen; Miller, William; Koguchi, Yoshinobu; Kaufmann, Johanna; Yanamandra, Niranjan; Griffin, Sue; Smothers, James; Adamow, Matthew; Lee, Jasme; Shen, Ronglai; Callahan, Margaret K; Redmond, William L

INBRX-106: a hexavalent OX40 agonist that drives superior antitumor responses via optimized receptor clustering

INBRX-106:一种六价OX40激动剂,可通过优化受体聚集驱动更强的抗肿瘤反应

Holay, Nisha; Yadav, Rashi; Ahn, Sae Jeong; Kasiewicz, Melissa J; Polovina, Anya; Rolig, Annah S; Staebler, Thi; Becklund, Bryan; Simons, Noah D; Koguchi, Yoshinobu; Eckelman, Brendan P; de Durana, Yaiza Diaz; Redmond, William L

Amine headgroups in ionizable lipids drive immune responses to lipid nanoparticles by binding to the receptors TLR4 and CD1d.

可电离脂质中的胺基头部基团通过与受体 TLR4 和 CD1d 结合,驱动对脂质纳米颗粒的免疫反应

Chaudhary Namit, Kasiewicz Lisa N, Newby Alexandra N, Arral Mariah L, Yerneni Saigopalakrishna S, Melamed Jilian R, LoPresti Samuel T, Fein Katherine C, Strelkova Petersen Daria M, Kumar Sushant, Purwar Rahul, Whitehead Kathryn A

GalNAc-Lipid nanoparticles enable non-LDLR dependent hepatic delivery of a CRISPR base editing therapy

GalNAc-脂质纳米粒子可实现非 LDLR 依赖性肝脏递送 CRISPR 碱基编辑疗法

Lisa N Kasiewicz, Souvik Biswas, Aaron Beach, Huilan Ren, Chaitali Dutta, Anne Marie Mazzola, Ellen Rohde, Alexandra Chadwick, Christopher Cheng, Sara P Garcia, Sowmya Iyer, Yuri Matsumoto, Amit V Khera, Kiran Musunuru, Sekar Kathiresan, Padma Malyala, Kallanthottathil G Rajeev, Andrew M Bellinger

Enhancement of anti-tumor efficacy of immune checkpoint blockade by alpha-TEA

α-TEA 增强免疫检查点阻断的抗肿瘤功效

William L Redmond, Melissa J Kasiewicz, Emmanuel T Akporiaye

Galectin-3 inhibition with belapectin combined with anti-OX40 therapy reprograms the tumor microenvironment to favor anti-tumor immunity

贝拉普汀抑制半乳糖凝集素 3 并联合抗 OX40 疗法可重新编程肿瘤微环境,以利于抗肿瘤免疫

Elizabeth R Sturgill, Annah S Rolig, Stefanie N Linch, Courtney Mick, Melissa J Kasiewicz, Zhaoyu Sun, Peter G Traber, Harold Shlevin, William L Redmond

NKTR-214 immunotherapy synergizes with radiotherapy to stimulate systemic CD8(+) T cell responses capable of curing multi-focal cancer.

NKTR-214 免疫疗法与放射疗法协同作用,刺激全身 CD8(+) T 细胞反应,从而治愈多灶性癌症

Walker Joshua M, Rolig Annah S, Charych Deborah H, Hoch Ute, Kasiewicz Melissa J, Rose Daniel C, McNamara Michael J, Hilgart-Martiszus Ian F, Redmond William L

Lipid nanoparticles silence tumor necrosis factor α to improve wound healing in diabetic mice

脂质纳米颗粒抑制肿瘤坏死因子α,从而改善糖尿病小鼠的伤口愈合。

Kasiewicz, Lisa N; Whitehead, Kathryn A

Combination OX40 agonism/CTLA-4 blockade with HER2 vaccination reverses T-cell anergy and promotes survival in tumor-bearing mice

OX40 激动剂/CTLA-4 阻断剂与 HER2 疫苗接种相结合可逆转 T 细胞无能并促进肿瘤小鼠生存

Stefanie N Linch, Melissa J Kasiewicz, Michael J McNamara, Ian F Hilgart-Martiszus, Mohammad Farhad, William L Redmond