日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Characterisation of an allosteric site in PLCγ enzymes and implications for development of their specific inhibitors

PLCγ酶变构位点的特征及其对特异性抑制剂开发的意义

Bunney, Tom D; Nyvall, Hunter G; Macrae, Calum; Lalović, Damjan; Gregory, Ashley; Le Huray, Kyle I P; Harvey, Nikita; Pinotsis, Nikos; Kalli, Antreas C; Waudby, Christopher A; Burke, John E; Katan, Matilda

Cell-free expression and SMA copolymer encapsulation of a functional receptor tyrosine kinase disease variant, FGFR3-TACC3

无细胞表达和SMA共聚物封装功能性受体酪氨酸激酶疾病变体FGFR3-TACC3

Snow, Alexander J D; Wijesiriwardena, Tharushi; Lane, Benjamin J; Farrell, Brendan; Dowdle, Polly C; Katan, Matilda; Muench, Stephen P; Breeze, Alexander L

Characterization of the membrane interactions of phospholipase Cγ reveals key features of the active enzyme

对磷脂酶Cγ膜相互作用的表征揭示了活性酶的关键特征

Le Huray, Kyle I P; Bunney, Tom D; Pinotsis, Nikos; Kalli, Antreas C; Katan, Matilda

Phosphatidylinositol(4,5)bisphosphate: diverse functions at the plasma membrane

磷脂酰肌醇(4,5)二磷酸:在质膜上的多种功能

Katan, Matilda; Cockcroft, Shamshad

Dynamic Allostery in PLCγ1 and Its Modulation by a Cancer Mutation Revealed by MD Simulation and NMR

分子动力学模拟和核磁共振揭示了PLCγ1的动态变构及其受癌症突变调控的机制。

Koss, Hans; Bunney, Tom D; Esposito, Diego; Martins, Marta; Katan, Matilda; Driscoll, Paul C

NMR backbone assignments of the tyrosine kinase domain of human fibroblast growth factor receptor 3 in apo state and in complex with inhibitor PD173074

人成纤维细胞生长因子受体 3 酪氨酸激酶结构域在无配体状态和与抑制剂 PD173074 复合物状态下的 NMR 骨架归属

Sanfelice, Domenico; Koss, Hans; Bunney, Tom D; Thompson, Gary S; Farrell, Brendan; Katan, Matilda; Breeze, Alexander L

Screening for protein-protein interactions using Förster resonance energy transfer (FRET) and fluorescence lifetime imaging microscopy (FLIM)

利用Förster共振能量转移(FRET)和荧光寿命成像显微镜(FLIM)筛选蛋白质-蛋白质相互作用

Margineanu, Anca; Chan, Jia Jia; Kelly, Douglas J; Warren, Sean C; Flatters, Delphine; Kumar, Sunil; Katan, Matilda; Dunsby, Christopher W; French, Paul M W

Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use

FGFR激酶中激活癌症突变的分布图谱及其对临床应用抑制剂的不同反应

Patani, Harshnira; Bunney, Tom D; Thiyagarajan, Nethaji; Norman, Richard A; Ogg, Derek; Breed, Jason; Ashford, Paul; Potterton, Andrew; Edwards, Mina; Williams, Sarah V; Thomson, Gary S; Pang, Camilla S M; Knowles, Margaret A; Breeze, Alexander L; Orengo, Christine; Phillips, Chris; Katan, Matilda

Quantitative in vivo optical tomography of cancer progression & vasculature development in adult zebrafish.

成年斑马鱼癌症进展和血管发育的定量体内光学断层扫描

Kumar Sunil, Lockwood Nicola, Ramel Marie-Christine, Correia Teresa, Ellis Matthew, Alexandrov Yuriy, Andrews Natalie, Patel Rachel, Bugeon Laurence, Dallman Margaret J, Brandner Sebastian, Arridge Simon, Katan Matilda, McGinty James, Frankel Paul, French Paul M W

Homo-FRET Based Biosensors and Their Application to Multiplexed Imaging of Signalling Events in Live Cells

基于同源FRET的生物传感器及其在活细胞信号事件多重成像中的应用

Warren, Sean C; Margineanu, Anca; Katan, Matilda; Dunsby, Chris; French, Paul M W