日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Differential regulation of mTOR signaling determines sensitivity to AKT inhibition in diffuse large B cell lymphoma

mTOR 信号的差异调节决定了弥漫性大 B 细胞淋巴瘤对 AKT 抑制的敏感性

Scott A Ezell, Suping Wang, Teeru Bihani, Zhongwu Lai, Shaun E Grosskurth, Suprawee Tepsuporn, Barry R Davies, Dennis Huszar, Kate F Byth

AZD5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2, and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts

AZD5438 是一种强效的口服细胞周期依赖性激酶 1、2 和 9 抑制剂,可在人类肿瘤异种移植中引起药效学变化并产生强效的抗肿瘤作用

Kate F Byth, Andrew Thomas, Gareth Hughes, Cheryl Forder, Alexandra McGregor, Catherine Geh, Sandra Oakes, Clive Green, Mike Walker, Nicholas Newcombe, Stephen Green, Jim Growcott, Andy Barker, Robert W Wilkinson