日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

TCRs with Distinct Specificity Profiles Use Different Binding Modes to Engage an Identical Peptide-HLA Complex

具有不同特异性特征的 TCR 使用不同的结合模式与相同的肽-HLA 复合物结合

Charlotte H Coles, Rachel M Mulvaney, Sunir Malla, Andrew Walker, Kathrine J Smith, Angharad Lloyd, Kate L Lowe, Michelle L McCully, Ruth Martinez Hague, Milos Aleksic, Jane Harper, Samantha J Paston, Zoe Donnellan, Fiona Chester, Katrin Wiederhold, Ross A Robinson, Andrew Knox, Andrea R Stacey, Jos

An approved in vitro approach to preclinical safety and efficacy evaluation of engineered T cell receptor anti-CD3 bispecific (ImmTAC) molecules

一种获批准的体外方法,用于评估工程化T细胞受体抗CD3双特异性抗体(ImmTAC)分子的临床前安全性和有效性。

Jane Harper ,Katherine J Adams ,Giovanna Bossi ,Debbie E Wright ,Andrea R Stacey ,Nicole Bedke ,Ruth Martinez-Hague ,Dan Blat ,Laure Humbert ,Hazel Buchanan ,Gabrielle S Le Provost ,Zoe Donnellan ,Ricardo J Carreira ,Samantha J Paston ,Luise U Weigand ,Martina Canestraro ,Joseph P Sanderson ,Sophie Botta Gordon-Smith ,Kate L Lowe ,Karolina A Rygiel ,Alex S Powlesland ,Annelise Vuidepot ,Namir J Hassan ,Brian J Cameron ,Bent K Jakobsen ,Joseph Dukes

Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets

沙门氏菌感染后,炎症通过血小板上的 CLEC-2 引发血栓形成

Jessica R Hitchcock, Charlotte N Cook, Saeeda Bobat, Ewan A Ross, Adriana Flores-Langarica, Kate L Lowe, Mahmood Khan, C Coral Dominguez-Medina, Sian Lax, Manuela Carvalho-Gaspar, Stefan Hubscher, G Ed Rainger, Mark Cobbold, Christopher D Buckley, Tim J Mitchell, Andrea Mitchell, Nick D Jones, N Van

The expression of mouse CLEC-2 on leucocyte subsets varies according to their anatomical location and inflammatory state

小鼠CLEC-2在白细胞亚群上的表达因其解剖位置和炎症状态而异。

Kate L Lowe ,Leyre Navarro-Núñez ,Cécile Bénézech ,Saba Nayar ,Bethany L Kingston ,Bernhard Nieswandt ,Francesca Barone ,Steve P Watson ,Christopher D Buckley ,Guillaume E Desanti

Natriuretic peptides induce weak VASP phosphorylation at Serine 239 in platelets

利钠肽诱导血小板中丝氨酸 239 位点的 VASP 发生弱磷酸化

Alessandra Borgognone, Kate L Lowe, Stephen P Watson, Melanie Madhani

CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development

巨核细胞/血小板谱系中的 CLEC-2 和 Syk 对发育至关重要

Brenda A Finney, Edina Schweighoffer, Leyre Navarro-Núñez, Cecile Bénézech, Francesca Barone, Craig E Hughes, Stacey A Langan, Kate L Lowe, Alice Y Pollitt, Diego Mourao-Sa, Steve Sheardown, Gerard B Nash, Nicholas Smithers, Caetano Reis e Sousa, Victor L J Tybulewicz, Steve P Watson