Katherine R Singleton相关文献与解析，生知库

MCB-613 exploits a collateral sensitivity in drug resistant EGFR-mutant non-small cell lung cancer through covalent inhibition of KEAP1

MCB-613 通过共价抑制 KEAP1 来发挥耐药性 EGFR 突变非小细胞肺癌的附带敏感性

doi:10.1101/2023.01.17.524094

Christopher F Bassil, Gray R Anderson, Benjamin Mayro, Kayleigh N Askin, Peter S Winter, Samuel Gruber, Tierney M Hall, Jacob P Hoj, Christian Cerda-Smith, Haley M Hutchinson, Shane T Killarney, Katherine R Singleton, Li Qin, Kévin Jubien-Girard, Cécile Favreau, Anthony R Martin, Guillaume Robert, R

Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer

利用拮抗性多效性设计化疗诱导的进化陷阱，以靶向癌症耐药性。

期刊:Nature Genetics

影响因子:31.7

doi:10.1038/s41588-020-0590-9

Kevin H Lin # ，Justine C Rutter # ，Abigail Xie ，Bryann Pardieu ，Emily T Winn ，Reinaldo Dal Bello ，Antoine Forget ，Raphael Itzykson ，Yeong-Ran Ahn ，Ziwei Dai ，Raiyan T Sobhan ，Gray R Anderson ，Katherine R Singleton ，Amy E Decker ，Peter S Winter ，Jason W Locasale ，Lorin Crawford ，Alexandre Puissant ，Kris C Wood

Evolved resistance to partial GAPDH inhibition results in loss of the Warburg effect and in a different state of glycolysis

对部分 GAPDH 抑制的抵抗力导致瓦博格效应丧失，糖酵解状态也不同

期刊:Journal of Biological Chemistry

影响因子:4

doi:10.1074/jbc.RA119.010903

Maria V Liberti, Annamarie E Allen, Vijyendra Ramesh, Ziwei Dai, Katherine R Singleton, Zufeng Guo, Jun O Liu, Kris C Wood, Jason W Locasale

信号转导

发表日期：2020

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Functional RNAi Screens Define Distinct Protein Kinase Vulnerabilities in EGFR-Dependent HNSCC Cell Lines

功能性 RNAi 筛选确定 EGFR 依赖性 HNSCC 细胞系中不同的蛋白激酶弱点

期刊:Molecular Pharmacology

影响因子:3.2

doi:10.1124/mol.119.117804

Trista K Hinz, Emily K Kleczko, Katherine R Singleton, Jacob Calhoun, Lindsay A Marek, Jihye Kim, Aik Choon Tan, Lynn E Heasley

ALK is a critical regulator of the MYC-signaling axis in ALK positive lung cancer

ALK 是 ALK 阳性肺癌中 MYC 信号轴的关键调节剂

期刊:Oncotarget

影响因子:

doi:10.18632/oncotarget.24260

Amanda B Pilling, Jihye Kim, Adriana Estrada-Bernal, Qiong Zhou, Anh T Le, Katherine R Singleton, Lynn E Heasley, Aik Choon Tan, James DeGregori, Robert C Doebele

Melanoma Therapeutic Strategies that Select against Resistance by Exploiting MYC-Driven Evolutionary Convergence

利用 MYC 驱动的进化趋同来选择对抗耐药性的黑色素瘤治疗策略

期刊:Cell Reports

影响因子:7.5

doi:10.1016/j.celrep.2017.11.022

Katherine R Singleton, Lorin Crawford, Elizabeth Tsui, Haley E Manchester, Ophelia Maertens, Xiaojing Liu, Maria V Liberti, Anniefer N Magpusao, Elizabeth M Stein, Jennifer P Tingley, Dennie T Frederick, Genevieve M Boland, Keith T Flaherty, Shannon J McCall, Clemens Krepler, Katrin Sproesser, Meenh

Kinome RNAi Screens Reveal Synergistic Targeting of MTOR and FGFR1 Pathways for Treatment of Lung Cancer and HNSCC

Kinome RNAi 筛选揭示 MTOR 和 FGFR1 通路协同靶向治疗肺癌和 HNSCC

期刊:Cancer Research

影响因子:12.5

doi:10.1158/0008-5472.CAN-15-0509

Katherine R Singleton, Trista K Hinz, Emily K Kleczko, Lindsay A Marek, Jeff Kwak, Taylor Harp, Jihye Kim, Aik Choon Tan, Lynn E Heasley

An Inducible TGF-β2-TGFβR Pathway Modulates the Sensitivity of HNSCC Cells to Tyrosine Kinase Inhibitors Targeting Dominant Receptor Tyrosine Kinases

可诱导的 TGF-β2-TGFβR 通路调节 HNSCC 细胞对靶向主要受体酪氨酸激酶的酪氨酸激酶抑制剂的敏感性

期刊:PLoS One

影响因子:2.9

doi:10.1371/journal.pone.0123600

Emily K Kleczko, Jihye Kim, Stephen B Keysar, Lydia R Heasley, Justin R Eagles, Matthew Simon, Marianne E Marshall, Katherine R Singleton, Antonio Jimeno, Aik-Choon Tan, Lynn E Heasley

Systematic identification of signaling pathways with potential to confer anticancer drug resistance

系统地识别可能产生抗癌药物耐药性的信号通路

期刊:Science Signaling

影响因子:

doi:10.1126/scisignal.aaa1877

Colin A Martz, Kathleen A Ottina, Katherine R Singleton, Jeff S Jasper, Suzanne E Wardell, Ashley Peraza-Penton, Gray R Anderson, Peter S Winter, Tim Wang, Holly M Alley, Lawrence N Kwong, Zachary A Cooper, Michael Tetzlaff, Pei-Ling Chen, Jeffrey C Rathmell, Keith T Flaherty, Jennifer A Wargo, Dona

Drug dependence in cancer is exploitable by optimally constructed treatment holidays

癌症患者的药物依赖性可以通过精心设计的治疗假期加以利用。

MCB-613 exploits a collateral sensitivity in drug resistant EGFR-mutant non-small cell lung cancer through covalent inhibition of KEAP1

MCB-613 通过共价抑制 KEAP1 来发挥耐药性 EGFR 突变非小细胞肺癌的附带敏感性

Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer

利用拮抗性多效性设计化疗诱导的进化陷阱，以靶向癌症耐药性。

Evolved resistance to partial GAPDH inhibition results in loss of the Warburg effect and in a different state of glycolysis

对部分 GAPDH 抑制的抵抗力导致瓦博格效应丧失，糖酵解状态也不同

Functional RNAi Screens Define Distinct Protein Kinase Vulnerabilities in EGFR-Dependent HNSCC Cell Lines

功能性 RNAi 筛选确定 EGFR 依赖性 HNSCC 细胞系中不同的蛋白激酶弱点

ALK is a critical regulator of the MYC-signaling axis in ALK positive lung cancer

ALK 是 ALK 阳性肺癌中 MYC 信号轴的关键调节剂

Melanoma Therapeutic Strategies that Select against Resistance by Exploiting MYC-Driven Evolutionary Convergence

利用 MYC 驱动的进化趋同来选择对抗耐药性的黑色素瘤治疗策略

Kinome RNAi Screens Reveal Synergistic Targeting of MTOR and FGFR1 Pathways for Treatment of Lung Cancer and HNSCC

Kinome RNAi 筛选揭示 MTOR 和 FGFR1 通路协同靶向治疗肺癌和 HNSCC

An Inducible TGF-β2-TGFβR Pathway Modulates the Sensitivity of HNSCC Cells to Tyrosine Kinase Inhibitors Targeting Dominant Receptor Tyrosine Kinases

可诱导的 TGF-β2-TGFβR 通路调节 HNSCC 细胞对靶向主要受体酪氨酸激酶的酪氨酸激酶抑制剂的敏感性

Systematic identification of signaling pathways with potential to confer anticancer drug resistance

系统地识别可能产生抗癌药物耐药性的信号通路