日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PARG is essential for Polθ-mediated DNA end-joining by removing repressive poly-ADP-ribose marks

PARG 通过去除抑制性的聚 ADP 核糖标记,对 Polθ 介导的 DNA 末端连接至关重要。

Umeshkumar Vekariya # ,Leonid Minakhin # ,Gurushankar Chandramouly ,Mrityunjay Tyagi ,Tatiana Kent ,Katherine Sullivan-Reed ,Jessica Atkins ,Douglas Ralph ,Margaret Nieborowska-Skorska ,Anna-Mariya Kukuyan ,Hsin-Yao Tang ,Richard T Pomerantz ,Tomasz Skorski

DNA polymerase θ protects leukemia cells from metabolically induced DNA damage

DNA聚合酶θ保护白血病细胞免受代谢引起的DNA损伤

Umeshkumar Vekariya, Monika Toma, Margaret Nieborowska-Skorska, Bac Viet Le, Marie-Christine Caron, Anna-Mariya Kukuyan, Katherine Sullivan-Reed, Paulina Podszywalow-Bartnicka, Kumaraswamy N Chitrala, Jessica Atkins, Malgorzata Drzewiecka, Wanjuan Feng, Joe Chan, Srinivas Chatla, Konstantin Golovine

Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination-Deficient Leukemia Cells

同时靶向 DNA 聚合酶 Theta 和 PARP1 或 RAD52 可在同源重组缺陷型白血病细胞中引发双重合成致死

Katherine Sullivan-Reed #, Monika M Toma #, Malgorzata Drzewiecka, Margaret Nieborowska-Skorska, Reza Nejati, Adam Karami, Mariusz A Wasik, Tomasz Sliwinski, Tomasz Skorski

TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors

TET2 和 DNMT3A 突变对 DNA 修复和白血病细胞对 PARP 抑制剂的敏感性产生不同的影响

Silvia Maifrede ,Bac Viet Le ,Margaret Nieborowska-Skorska ,Konstantin Golovine ,Katherine Sullivan-Reed ,Wangisa M B Dunuwille ,Joseph Nacson ,Michael Hulse ,Kelsey Keith ,Jozef Madzo ,Lisa Beatrice Caruso ,Zachary Gazze ,Zhaorui Lian ,Antonella Padella ,Kumaraswamy N Chitrala ,Boris A Bartholdy ,Ksenia Matlawska-Wasowska ,Daniela Di Marcantonio ,Giorgia Simonetti ,Georg Greiner ,Stephen M Sykes ,Peter Valent ,Elisabeth M Paietta ,Martin S Tallman ,Hugo F Fernandez ,Mark R Litzow ,Mark D Minden ,Jian Huang ,Giovanni Martinelli ,George S Vassiliou ,Italo Tempera ,Katarzyna Piwocka ,Neil Johnson ,Grant A Challen ,Tomasz Skorski

Polθ promotes the repair of 5'-DNA-protein crosslinks by microhomology-mediated end-joining

Polθ通过微同源介导的末端连接促进5’-DNA-蛋白质交联的修复

Gurushankar Chandramouly, Shuren Liao, Timur Rusanov, Nikita Borisonnik, Marissa L Calbert, Tatiana Kent, Katherine Sullivan-Reed, Umeshkumar Vekariya, Ekaterina Kashkina, Tomasz Skorski, Hong Yan, Richard T Pomerantz

TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment

TGFβR-SMAD3信号通路诱导骨髓微环境中对PARP抑制剂的耐药性

Bac Viet Le ,Paulina Podszywalow-Bartnicka ,Silvia Maifrede ,Katherine Sullivan-Reed ,Margaret Nieborowska-Skorska ,Konstantin Golovine ,Juo-Chin Yao ,Reza Nejati ,Kathy Q Cai ,Lisa Beatrice Caruso ,Julian Swatler ,Michal Dabrowski ,Zhaorui Lian ,Peter Valent ,Elisabeth M Paietta ,Ross L Levine ,Hugo F Fernandez ,Martin S Tallman ,Mark R Litzow ,Jian Huang ,Grant A Challen ,Daniel Link ,Italo Tempera ,Mariusz A Wasik ,Katarzyna Piwocka ,Tomasz Skorski

Novel allosteric PARP1 inhibitors for the treatment of BRCA-deficient leukemia

新型变构PARP1抑制剂用于治疗BRCA缺陷型白血病

Elizabeth Hewlett, Monika Toma, Katherine Sullivan-Reed, John Gordo, Tomasz Sliwinski, Alexei Tulin, Wayne E Childers, Tomasz Skorski

Tyrosine kinase inhibitor-induced defects in DNA repair sensitize FLT3(ITD)-positive leukemia cells to PARP1 inhibitors

酪氨酸激酶抑制剂诱导的 DNA 修复缺陷使 FLT3(ITD)阳性白血病细胞对 PARP1 抑制剂敏感

Silvia Maifrede, Margaret Nieborowska-Skorska, Katherine Sullivan-Reed, Yashodhara Dasgupta, Paulina Podszywalow-Bartnicka, Bac Viet Le, Martyna Solecka, Zhaorui Lian, Elizaveta A Belyaeva, Alina Nersesyan, Marcin M Machnicki, Monika Toma, Nicolas Chatain, Malgorzata Rydzanicz, Huaqing Zhao, Jarosla

Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Tumor Cells

同时靶向 PARP1 和 RAD52 可在 BRCA 缺陷肿瘤细胞中引发双重合成致死

Katherine Sullivan-Reed, Elisabeth Bolton-Gillespie, Yashodhara Dasgupta, Samantha Langer, Micheal Siciliano, Margaret Nieborowska-Skorska, Kritika Hanamshet, Elizaveta A Belyaeva, Andrea J Bernhardy, Jaewong Lee, Morgan Moore, Huaqing Zhao, Peter Valent, Ksenia Matlawska-Wasowska, Markus Müschen, S

IGH/MYC Translocation Associates with BRCA2 Deficiency and Synthetic Lethality to PARP1 Inhibitors

IGH/MYC 易位与 BRCA2 缺陷及 PARP1 抑制剂的合成致死性相关

Silvia Maifrede, Kayla Martin, Paulina Podszywalow-Bartnicka, Katherine Sullivan-Reed, Samantha K Langer, Reza Nejati, Yashodhara Dasgupta, Michael Hulse, Daniel Gritsyuk, Margaret Nieborowska-Skorska, Lena N Lupey-Green, Huaqing Zhao, Katarzyna Piwocka, Mariusz A Wasik, Italo Tempera, Tomasz Skorsk