日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structure-guided design of purine-based probes for selective Nek2 inhibition

嘌呤类探针的结构引导设计用于选择性 Nek2 抑制

Christopher R Coxon, Christopher Wong, Richard Bayliss, Kathy Boxall, Katherine H Carr, Andrew M Fry, Ian R Hardcastle, Christopher J Matheson, David R Newell, Mangaleswaran Sivaprakasam, Huw Thomas, David Turner, Sharon Yeoh, Lan Z Wang, Roger J Griffin, Bernard T Golding, Céline Cano

Fragment-based screening maps inhibitor interactions in the ATP-binding site of checkpoint kinase 2

基于片段的筛选可绘制检查点激酶 2 的 ATP 结合位点中抑制剂的相互作用

M Cris Silva-Santisteban, Isaac M Westwood, Kathy Boxall, Nathan Brown, Sam Peacock, Craig McAndrew, Elaine Barrie, Meirion Richards, Amin Mirza, Antony W Oliver, Rosemary Burke, Swen Hoelder, Keith Jones, G Wynne Aherne, Julian Blagg, Ian Collins, Michelle D Garrett, Rob L M van Montfort

The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design

通过高通量筛选和结构引导药物设计发现有效的核糖体 S6 激酶抑制剂

Sylvain Couty, Isaac M Westwood, Andrew Kalusa, Celine Cano, Jon Travers, Kathy Boxall, Chiau Ling Chow, Sam Burns, Jessica Schmitt, Lisa Pickard, Caterina Barillari, P Craig McAndrew, Paul A Clarke, Spiros Linardopoulos, Roger J Griffin, G Wynne Aherne, Florence I Raynaud, Paul Workman, Keith Jones

Design of potent and selective hybrid inhibitors of the mitotic kinase Nek2: structure-activity relationship, structural biology, and cellular activity

有丝分裂激酶 Nek2 的强效和选择性混合抑制剂的设计:结构-活性关系、结构生物学和细胞活性

Paolo Innocenti, Kwai-Ming J Cheung, Savade Solanki, Corine Mas-Droux, Fiona Rowan, Sharon Yeoh, Kathy Boxall, Maura Westlake, Lisa Pickard, Tara Hardy, Joanne E Baxter, G Wynne Aherne, Richard Bayliss, Andrew M Fry, Swen Hoelder

Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2

基于结构的设计有效且选择性的 2-(喹唑啉-2-基)苯酚检查点激酶 2 抑制剂

John J Caldwell, Emma J Welsh, Cornelis Matijssen, Victoria E Anderson, Laurent Antoni, Kathy Boxall, Frederique Urban, Angela Hayes, Florence I Raynaud, Laurent J M Rigoreau, Tony Raynham, G Wynne Aherne, Laurence H Pearl, Antony W Oliver, Michelle D Garrett, Ian Collins

Aminopyrazine inhibitors binding to an unusual inactive conformation of the mitotic kinase Nek2: SAR and structural characterization

氨基吡嗪抑制剂与有丝分裂激酶 Nek2 的异常非活性构象结合:SAR 和结构表征

Daniel K Whelligan, Savade Solanki, Dawn Taylor, Douglas W Thomson, Kwai-Ming J Cheung, Kathy Boxall, Corine Mas-Droux, Caterina Barillari, Samantha Burns, Charles G Grummitt, Ian Collins, Rob L M van Montfort, G Wynne Aherne, Richard Bayliss, Swen Hoelder

NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis

NVP-AUY922:一种新型热休克蛋白 90 抑制剂,可抑制异种移植肿瘤的生长、血管生成和转移

Suzanne A Eccles, Andy Massey, Florence I Raynaud, Swee Y Sharp, Gary Box, Melanie Valenti, Lisa Patterson, Alexis de Haven Brandon, Sharon Gowan, Frances Boxall, Wynne Aherne, Martin Rowlands, Angela Hayes, Vanessa Martins, Frederique Urban, Kathy Boxall, Chrisostomos Prodromou, Laurence Pearl, Kar