日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A reprogrammed genetic code consisting of 32 distinct amino acids

由32种不同氨基酸组成的重新编程的遗传密码

Katoh, Takayuki; Suga, Hiroaki

Engineering of tRNAPro1E2 anticodon stem enhances multiple/consecutive ribosomal incorporation of N-methyl-l-α-amino acids and d-α-amino acids

tRNAPro1E2反密码子茎的工程改造增强了N-甲基-L-α-氨基酸和D-α-氨基酸的多次/连续核糖体掺入

Hirashima, Ryoichi; Katoh, Takayuki; Suga, Hiroaki

The Alteromonas macleodii ribosome enables consecutive incorporation of bulky D-amino acids into peptides

麦克劳德氏交替单胞菌核糖体能够将体积较大的D-氨基酸连续掺入肽链中。

Katoh, Takayuki; Takada, Hiraku; Sigal, Maxwell; Suga, Hiroaki

The tRNA moieties of both aminoacyl-tRNA substrates of a cyclodipeptide synthase share a common binding site, as revealed by RNA microhelices mimicking tRNA acceptor arms

环二肽合成酶的两个氨酰-tRNA底物的tRNA部分共享一个共同的结合位点,这已通过模拟tRNA受体臂的RNA微螺旋得到证实。

Marouf, Zahra; Tellier-Lebegue, Carine; Glousieau, Matthieu; Morellet, Nelly; Cuniasse, Philippe; Bourand-Plantefol, Alexa; Plancqueel, Stéphane; Mahmoudi, Ikram; Andreani, Jessica; Legrand, Pierre; Ropars, Virginie; Ruedas, Rémi; Hermouet, Léa-Fleur; Moutiez, Mireille; Nhiri, Naïma; Fonvielle, Matthieu; Bressanelli, Stéphane; Katoh, Takayuki; Fernandez Varela, Paloma; Lescop, Ewen; Charbonnier, Jean-Baptiste; Gondry, Muriel

Mirror-Image Random Nonstandard Peptides Integrated Discovery (MI-RaPID) Technology Yields Highly Stable and Selective Macrocyclic Peptide Inhibitors for Matrix Metallopeptidase 7

镜像随机非标准肽整合发现(MI-RaPID)技术可获得高度稳定且选择性的基质金属蛋白酶7大环肽抑制剂

Ghareeb, Hiba; Yi Li, Choi; Shenoy, Anjana; Rotenberg, Naama; Shifman, Julia M; Katoh, Takayuki; Sagi, Irit; Suga, Hiroaki; Metanis, Norman

A super versatile flexizyme system with phenol esters for genetic code reprogramming

一种用途广泛的柔性酶系统,利用酚酯进行基因密码重编程

Choi, Yun-Kyu; Katoh, Takayuki; Beattie, Adam; Suga, Hiroaki

De Novo Discovery of α,α-Disubstituted α-amino Acid-Containing α-helical Peptides as Competitive PPARγ PPI Inhibitors

从头发现含α,α-二取代α-氨基酸的α-螺旋肽作为竞争性PPARγ PPI抑制剂

Sigal, Maxwell; Egner, Markus; Okada, Chikako; Merk, Daniel; Sengoku, Toru; Katoh, Takayuki; Suga, Hiroaki

Promoting ribosomal incorporation of backbone-modifying nonproteinogenic amino acids into nascent peptides by ATP-binding cassette family-F proteins and EF-P

ATP结合盒转运蛋白家族F蛋白和EF-P促进核糖体将骨架修饰的非蛋白源性氨基酸掺入新生肽链中。

Katoh, Takayuki; Suga, Hiroaki

RaPID discovery of cell-permeable helical peptide inhibitors con-taining cyclic β-amino acids against SARS-CoV-2 main protease

快速发现含有环状β-氨基酸的细胞渗透性螺旋肽抑制剂,该抑制剂可抑制SARS-CoV-2主蛋白酶

Kawai, Marina; Malla, Tika R; Chan, H T Henry; Tumber, Anthony; Brewitz, Lennart; Salah, Eidarus; Terasaka, Naohiro; Katoh, Takayuki; Kawamura, Akane; Schofield, Christopher J; Duarte, Fernanda; Suga, Hiroaki

Engineering tRNAs for the Ribosomal Translation of Non-proteinogenic Monomers.

改造 tRNA 以进行非蛋白质单体的核糖体翻译

Sigal Maxwell, Matsumoto Satomi, Beattie Adam, Katoh Takayuki, Suga Hiroaki