日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structure-guided design of partial agonists at an opioid receptor.

基于结构的阿片受体部分激动剂设计

Varga Balazs R, Bernhard Sarah M, El Daibani Amal, Zaidi Saheem A, Lam Jordy H, Aguilar Jhoan, Appourchaux Kevin, Nazarova Antonina L, Kouvelis Alexa, Shinouchi Ryosuke, Hammond Haylee R, Eans Shainnel O, Weinreb Violetta, Margolis Elyssa B, Fay Jonathan F, Huang Xi-Ping, Pradhan Amynah, Katritch Vsevolod, McLaughlin Jay P, Majumdar Susruta, Che Tao

Structural insights into the mechanism of activation and inhibition of the prostaglandin D2 receptor 1.

前列腺素D2受体1激活和抑制机制的结构性见解

Davoudinasab Behnaz, Raskovalov Aleksey, Lee Woojin, Kim Donggyun, Kim Heesoo, Lam Jordy Homing, Han Gye Won, Katritch Vsevolod, Cherezov Vadim

Maternal inheritance suppresses CAA and amyloid plaques in 5xFAD (Tg7031)/APOE4 mice

母系遗传抑制5xFAD (Tg7031)/APOE4小鼠的CAA和淀粉样斑块形成

Saadi, Fareeha; Katritch, Ilia V; Parhizkar, Samira; Lugo, Brisa; Cho, Yoonho; Ulrich, Jason D; Holtzman, David M

Exceptionally Potent Chiral Anandamide Analogs.

超强效手性花生四烯酸乙醇胺类似物。

Georgiadis Markos-Orestis, Ferreras Elena, Ji Lipin, Ferreira Luana Assis, Hainline John, Tong Fei, Dang Vuong Q, Faragher Alexandra, Sadybekov Anastasiia V, Bohn Laura M, Katritch Vsevolod, Hohmann Andrea G, Makriyannis Alexandros, Nikas Spyros P

Novel Tetraolefinic Chain Phenyl Substituted Endocannabinoid Probes.

新型四烯烃链苯基取代内源性大麻素探针。

Georgiadis Markos-Orestis, Ji Lipin, Tong Fei, Dang Vuong Q, Ferreira Luana Assis, Faragher Alexandra, Tran Ngan, Sadybekov Anastasiia V, Ganapathy Suthakar, Zvonok Nikolai, Katritch Vsevolod, Hohmann Andrea G, Bohn Laura M, Makriyannis Alexandros, Nikas Spyros P

Synthesis and Pharmacology of a Morphinan-Derived Dual Mu-Kappa Opioid Receptor Agonist Analgesic.

吗啡烷衍生的双重μ-κ阿片受体激动剂镇痛药的合成与药理学研究

Varga Balazs R, Uprety Rajendra, Paul Barnali, Knoll Alexis, Ramos-Gonzalez Nokomis, Appourchaux Kevin, Taylor Tori, Turgutalp Bengisu, Shinouchi Ryosuke, Eans Shainnel O, Williams Ashai K, Vasquez-Grinnell Steven G, Zaidi Saheem, Nazarova Antonina L, Varadi Andras, Le Rouzic Valerie, Brown Taylor G, Martinez Shani, Ansonoff Michael, Dardashti Rebecca Notis, Hunkele Amanda, Subrath Joan, Welch Matthew, Xu Jin, Rossi Grace C, Pintar John, Pasternak Gavril W, Katritch Vsevolod, McLaughlin Jay P, Pan Ying Xian, Majumdar Susruta

Differential Effects of Sodium on Agonist-Induced Conformational Transitions and Signaling at μ and κ Opioid Receptors

钠对μ和κ阿片受体激动剂诱导的构象转变和信号传导的不同影响

Kuijer, Michael Bram; Fulton, Camryn J; Albert, Talia L; Knobloch, Paloma; Wang, Jing; Krumm, Brian E; Che, Tao; Varga, Balazs R; Majumdar, Susruta; Katritch, Vsevolod; Gumpper, Ryan H; Kenakin, Terry; Huang, Xi-Ping; Roth, Bryan L

Differential effects of sodium on agonist-induced conformational transitions and signaling at μ and κ opioid receptors

钠对μ和κ阿片受体激动剂诱导的构象转变和信号传导的不同影响

Kuijer, Bram; Fulton, Camryn J; Albert, Talia L; Knobloch, Paloma M; Wang, Jing; Krumm, Brian E; Che, Tao; Varga, Balazs R; Majumdar, Susruta; Katritch, Vsevolod; Gumpper, Ryan H; Kenakin, Terry; Huang, Xi-Ping; Roth, Bryan L

Navigating structure-based drug discovery with emerging innovations in physics- and knowledge-based approaches

利用物理学和知识方法的新兴创新,探索基于结构的药物发现之路

Lam, Jordy Homing; Katritch, Vsevolod

The evolution of computational research in a data-centric world

以数据为中心的世界中计算研究的演变

Deshpande, Dhrithi; Chhugani, Karishma; Ramesh, Tejasvene; Pellegrini, Matteo; Shifman, Sagiv; Abedalthagafi, Malak S; Alqahtani, Saleh; Ye, Jimmie; Liu, Xiaole Shirley; Leek, Jeffrey T; Brazma, Alvis; Ophoff, Roel A; Rao, Gauri; Butte, Atul J; Moore, Jason H; Katritch, Vsevolod; Mangul, Serghei