日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Virus-free CRISPR knockin of a chimeric antigen receptor into KLRC1 generates potent GD2-specific natural killer cells.

利用无病毒 CRISPR 技术将嵌合抗原受体敲入 KLRC1 中,可产生强效的 GD2 特异性自然杀伤细胞

Shankar Keerthana, Zingler-Hoslet Isabelle, Tabima Diana M, Zima Seth, Shi Lei, Gimse Kirstan, Forsberg Matthew H, Katta Varun, Davis Sage Z, Maldonado Daniel, Russell Brittany E, Murtaza Muhammed, Tsai Shengdar Q, Ayuso Jose M, Capitini Christian M, Saha Krishanu

Population-scale cellular GUIDE-seq-2 and biochemical CHANGE-seq-R profiles reveal human genetic variation frequently affects Cas9 off-target activity

群体规模的细胞 GUIDE-seq-2 和生化 CHANGE-seq-R 分析表明,人类遗传变异经常影响 Cas9 的脱靶活性。

Lazzarotto, Cicera R; Li, Yichao; Flory, Ashley R; Chyr, Jacqueline; Yang, Muyu; Katta, Varun; Urbina, Elizabeth; Lee, GaHyun; Wood, Rachael; Matsubara, Azusa; Rashkin, Sara R; Ma, Jian; Cheng, Yong; Tsai, Shengdar Q

Brain-wide Genome Editing via STEP-RNPs for Treatment of Angelman Syndrome

利用STEP-RNP进行全脑基因组编辑治疗安格曼综合征

Lu, Xiaona; Xie, Ying; Bao, Youmei; Yu, Jiang; Wang, Zefeng; Fan, Jiali; Sheu, Wendy C; Long, Gretchen; Tu, Zewei; Tong, Jie; Manquen, Garret; Li, Yichao; Katta, Varun; Chow, Ryan; Chen, Binfan; Meng, Zhouqi; Ma, Ying-Hong; Qiu, Caihong; Chen, Sidi; Tsai, Shengdar Q; De Kumar, Bony; Hendry, Caroline E; Jiang, Yong-Hui; Zhou, Jiangbing

Virus-free CRISPR knock-in of a chimeric antigen receptor into KLRC1 generates potent GD2-specific natural killer cells

利用无病毒 CRISPR 技术将嵌合抗原受体敲入 KLRC1 基因,可产生强效的 GD2 特异性自然杀伤细胞。

Shankar, Keerthana; Zingler-Hoslet, Isabella; Shi, Lei; Katta, Varun; Russell, Brittany E; Tsai, Shengdar Q; Capitini, Christian M; Saha, Krishanu

Enzyme replacement for GM1-gangliosidosis: Uptake, lysosomal activation, and cellular disease correction using a novel β-galactosidase:RTB lectin fusion

GM1神经节苷脂沉积症的酶替代疗法:利用新型β-半乳糖苷酶:RTB凝集素融合蛋白进行摄取、溶酶体激活和细胞疾病矫正

Condori, Jose; Acosta, Walter; Ayala, Jorge; Katta, Varun; Flory, Ashley; Martin, Reid; Radin, Jonathan; Cramer, Carole L; Radin, David N