日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Bioengineering of coagulation factor VIII for efficient expression through elimination of a dispensable disulfide loop

通过消除不必要的二硫键环,对凝血因子VIII进行生物工程改造,以实现高效表达。

Selvaraj, S R; Scheller, A N; Miao, H Z; Kaufman, R J; Pipe, Steven W

Mechanisms of beta-cell death in response to double-stranded (ds) RNA and interferon-gamma: dsRNA-dependent protein kinase apoptosis and nitric oxide-dependent necrosis.

双链 RNA 和干扰素-γ 诱导 β 细胞死亡的机制:dsRNA 依赖性蛋白激酶凋亡和一氧化氮依赖性坏死

Scarim A L, Arnush M, Blair L A, Concepcion J, Heitmeier M R, Scheuner D, Kaufman R J, Ryerse J, Buller R M, Corbett J A

New ways of initiating translation in eukaryotes

真核生物启动翻译的新途径

Schneider, R; Agol, V I; Andino, R; Bayard, F; Cavener, D R; Chappell, S A; Chen, J J; Darlix, J L; Dasgupta, A; Donzé, O; Duncan, R; Elroy-Stein, O; Farabaugh, P J; Filipowicz, W; Gale, M Jr; Gehrke, L; Goldman, E; Groner, Y; Harford, J B; Hatzglou, M; He, B; Hellen, C U; Hentze, M W; Hershey, J; Hershey, P; Hohn, T; Holcik, M; Hunter, C P; Igarashi, K; Jackson, R; Jagus, R; Jefferson, L S; Joshi, B; Kaempfer, R; Katze, M; Kaufman, R J; Kiledjian, M; Kimball, S R; Kimchi, A; Kirkegaard, K; Koromilas, A E; Krug, R M; Kruys, V; Lamphear, B J; Lemon, S; Lloyd, R E; Maquat, L E; Martinez-Salas, E; Mathews, M B; Mauro, V P; Miyamoto, S; Mohr, I; Morris, D R; Moss, E G; Nakashima, N; Palmenberg, A; Parkin, N T; Pe'ery, T; Pelletier, J; Peltz, S; Pestova, T V; Pilipenko, E V; Prats, A C; Racaniello, V; Read, G S; Rhoads, R E; Richter, J D; Rivera-Pomar, R; Rouault, T; Sachs, A; Sarnow, P; Scheper, G C; Schiff, L; Schoenberg, D R; Semler, B L; Siddiqui, A; Skern, T; Sonenberg, N; Sossin, W; Standart, N; Tahara, S M; Thomas, A A; Toulmé, J J; Wilusz, J; Wimmer, E; Witherell, G; Wormington, M

The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response

哺乳动物IRE1的核糖核酸内切酶活性可自身调节其mRNA,并且是未折叠蛋白反应所必需的。

Tirasophon, W; Lee, K; Callaghan, B; Welihinda, A; Kaufman, R J

The unfolded protein response represses nitrogen-starvation induced developmental differentiation in yeast

未折叠蛋白反应抑制酵母中氮饥饿诱导的发育分化。

Schröder, M; Chang, J S; Kaufman, R J

Correction of genetic disease by making sense from nonsense

通过从无意义中得出有意义的结论来纠正遗传疾病

Kaufman, R J

A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

哺乳动物细胞中,从内质网到细胞核的应激反应通路需要一种新型的双功能蛋白激酶/核糖核酸内切酶(Ire1p)。

Tirasophon, W; Welihinda, A A; Kaufman, R J

Expression of mutant eukaryotic initiation factor 2 alpha subunit (eIF-2 alpha) reduces inhibition of guanine nucleotide exchange activity of eIF-2B mediated by eIF-2 alpha phosphorylation

突变型真核起始因子2α亚基(eIF-2α)的表达降低了eIF-2α磷酸化介导的eIF-2B鸟嘌呤核苷酸交换活性的抑制作用。

Ramaiah, K V; Davies, M V; Chen, J J; Kaufman, R J

Dexamethasone negatively regulates the activity of a chimeric dihydrofolate reductase/glucocorticoid receptor protein

地塞米松负向调节嵌合二氢叶酸还原酶/糖皮质激素受体蛋白的活性。

Israel, D I; Kaufman, R J

Expression of bovine vitamin K-dependent carboxylase activity in baculovirus-infected insect cells

牛维生素K依赖性羧化酶活性在杆状病毒感染的昆虫细胞中的表达

Roth, D A; Rehemtulla, A; Kaufman, R J; Walsh, C T; Furie, B; Furie, B C