日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Inhibitor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoV

MERS-CoV 木瓜蛋白酶样蛋白酶抑制剂识别特异性可能与 SARS-CoV 不同

Hyun Lee, Hao Lei, Bernard D Santarsiero, Joseph L Gatuz, Shuyi Cao, Amy J Rice, Kavankumar Patel, Michael Z Szypulinski, Isabel Ojeda, Arun K Ghosh, Michael E Johnson

Identification of novel drug scaffolds for inhibition of SARS-CoV 3-Chymotrypsin-like protease using virtual and high-throughput screenings

使用虚拟和高通量筛选鉴定用于抑制 SARS-CoV 3-胰凝乳蛋白酶样蛋白酶的新型药物支架

Hyun Lee, Anuradha Mittal, Kavankumar Patel, Joseph L Gatuz, Lena Truong, Jaime Torres, Debbie C Mulhearn, Michael E Johnson

Synergistic inhibitor binding to the papain-like protease of human SARS coronavirus: mechanistic and inhibitor design implications

协同抑制剂与人类 SARS 冠状病毒木瓜蛋白酶样蛋白酶的结合:机制和抑制剂设计意义

Hyun Lee, Shuyi Cao, Kirk E Hevener, Lena Truong, Joseph L Gatuz, Kavankumar Patel, Arun K Ghosh, Michael E Johnson

High-throughput screening (HTS) and hit validation to identify small molecule inhibitors with activity against NS3/4A proteases from multiple hepatitis C virus genotypes

通过高通量筛选 (HTS) 和命中验证来鉴定对多种丙型肝炎病毒基因型的 NS3/4A 蛋白酶具有活性的小分子抑制剂

Hyun Lee, Tian Zhu, Kavankumar Patel, Yan-Yan Zhang, Lena Truong, Kirk E Hevener, Joseph L Gatuz, Gitanjali Subramanya, Hyun-Young Jeong, Susan L Uprichard, Michael E Johnson