日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Safety, pharmacokinetics, and pharmacodynamics of Gln-1062, a prodrug of galantamine

加兰他敏前药 Gln-1062 的安全性、药代动力学和药效学研究

Bakker, Charlotte; van der Aart, Jasper; Hart, Ellen P; Klaassen, Erica S; Bergmann, Kirsten R; van Esdonk, Michiel J; Kay, Denis G; Groeneveld, Geert Jan

Neurotrophic effects of progranulin in vivo in reversing motor neuron defects caused by over or under expression of TDP-43 or FUS

体内前粒蛋白的神经营养作用可逆转由TDP-43或FUS过度表达或表达不足引起的运动神经元缺陷

Chitramuthu, Babykumari P; Kay, Denis G; Bateman, Andrew; Bennett, Hugh P J

First in human study with a prodrug of galantamine: Improved benefit-risk ratio?

首次在人体中使用加兰他敏前药:获益风险比是否提高?

Baakman, Anne C; 't Hart, Ellen; Kay, Denis G; Stevens, Jasper; Klaassen, Erica S; Maelicke, Alfred; Groeneveld, Geert J

Progranulin is expressed within motor neurons and promotes neuronal cell survival.

前粒蛋白在运动神经元内表达,并促进神经元细胞存活

Ryan Cara L, Baranowski David C, Chitramuthu Babykumari P, Malik Suneil, Li Zhi, Cao Mingju, Minotti Sandra, Durham Heather D, Kay Denis G, Shaw Christopher A, Bennett Hugh P J, Bateman Andrew

Oligodendrocyte-specific expression of human immunodeficiency virus type 1 Nef in transgenic mice leads to vacuolar myelopathy and alters oligodendrocyte phenotype in vitro.

转基因小鼠中少突胶质细胞特异性表达人类免疫缺陷病毒 1 型 Nef 会导致空泡性脊髓病,并改变体外少突胶质细胞的表型

Radja Fatiha, Kay Denis G, Albrecht Steffen, Jolicoeur Paul

Cardiac disease in transgenic mice expressing human immunodeficiency virus-1 nef in cells of the immune system

转基因小鼠在免疫系统细胞中表达人类免疫缺陷病毒-1 nef 基因,导致心脏疾病

Kay, Denis G; Yue, Ping; Hanna, Zaher; Jothy, Serge; Tremblay, Etienne; Jolicoeur, Paul