Kay Grobe相关文献与解析，生知库 | 链接生命科学的每一步

A Residual N-Terminal Peptide Enhances Signaling of Depalmitoylated Hedgehog to the Patched Receptor

残留的 N 端肽增强去棕榈酰化 Hedgehog 向 Patched 受体的信号传导

期刊:Journal of Developmental Biology

影响因子:2.2

doi:10.3390/jdb12020011

Sophia F Ehlers, Dominique Manikowski, Georg Steffes, Kristina Ehring, Fabian Gude, Kay Grobe

Hedgehog is relayed through dynamic heparan sulfate interactions to shape its gradient

Hedgehog 通过动态硫酸乙酰肝素相互作用来形成其梯度

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-023-36450-y

Fabian Gude #, Jurij Froese #, Dominique Manikowski #, Daniele Di Iorio, Jean-Noël Grad, Seraphine Wegner, Daniel Hoffmann, Melissa Kennedy, Ralf P Richter, Georg Steffes, Kay Grobe

Drosophila hedgehog signaling range and robustness depend on direct and sustained heparan sulfate interactions

果蝇刺猬信号范围和稳健性取决于直接和持续的硫酸乙酰肝素相互作用

期刊:Frontiers in Molecular Biosciences

影响因子:3.9

doi:10.3389/fmolb.2023.1130064

Dominique Manikowski, Georg Steffes, Jurij Froese, Sebastian Exner, Kristina Ehring, Fabian Gude, Daniele Di Iorio, Seraphine V Wegner, Kay Grobe

Conserved cholesterol-related activities of Dispatched 1 drive Sonic hedgehog shedding from the cell membrane

Dispatched 1 驱动 Sonic hedgehog 从细胞膜脱落的胆固醇相关活性

期刊:Journal of Cell Science

影响因子:3.3

doi:10.1242/jcs.258672

Kristina Ehring, Dominique Manikowski, Jonas Goretzko, Jurij Froese, Fabian Gude, Petra Jakobs, Ursula Rescher, Uwe Kirchhefer, Kay Grobe

Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production

病变边缘的成熟少突胶质细胞限制脱髓鞘，并通过硫酸肝素的产生促进髓鞘修复

期刊:Elife

影响因子:6.4

doi:10.7554/eLife.51735

Magali Macchi #, Karine Magalon #, Céline Zimmer, Elitsa Peeva, Bilal El Waly, Béatrice Brousse, Sarah Jaekel, Kay Grobe, Friedemann Kiefer, Anna Williams, Myriam Cayre, Pascale Durbec

Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis

分泌性金属蛋白酶 ADAMTS9 和 ADAMTS20 在纤毛发生过程中对纤毛囊泡生长具有非典型作用

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-019-08520-7

Sumeda Nandadasa, Caroline M Kraft, Lauren W Wang, Anna O'Donnell, Rushabh Patel, Heon Yung Gee, Kay Grobe, Timothy C Cox, Friedhelm Hildebrandt, Suneel S Apte

囊泡

发表日期：2019

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Soluble Heparin and Heparan Sulfate Glycosaminoglycans Interfere with Sonic Hedgehog Solubilization and Receptor Binding

可溶性肝素和硫酸肝素糖胺聚糖干扰 Sonic Hedgehog 溶解和受体结合

期刊:Molecules

影响因子:4.2

doi:10.3390/molecules24081607

Dominique Manikowski, Petra Jakobs, Hamodah Jboor, Kay Grobe

Proteolytic processing of palmitoylated Hedgehog peptides specifies the 3-4 intervein region of the Drosophila wing

棕榈酰化 Hedgehog 肽的蛋白水解加工指定了果蝇翅脉间 3-4 个区域

期刊:Elife

影响因子:6.4

doi:10.7554/eLife.33033

Sabine Schürmann, Georg Steffes, Dominique Manikowski, Philipp Kastl, Ursula Malkus, Shyam Bandari, Stefanie Ohlig, Corinna Ortmann, Rocio Rebollido-Rios, Mandy Otto, Harald Nüsse, Daniel Hoffmann, Christian Klämbt, Milos Galic, Jürgen Klingauf, Kay Grobe

Disrupting Hedgehog Cardin-Weintraub sequence and positioning changes cellular differentiation and compartmentalization in vivo

破坏 Hedgehog Cardin-Weintraub 序列和定位会改变体内细胞的分化和区室化

期刊:Development

影响因子:3.7

doi:10.1242/dev.167221

Philipp Kastl, Dominique Manikowski, Georg Steffes, Sabine Schürmann, Shyam Bandari, Christian Klämbt, Kay Grobe

Two-way Dispatched function in Sonic hedgehog shedding and transfer to high-density lipoproteins

音猬因子脱落和向高密度脂蛋白转移的双向调度功能

A Residual N-Terminal Peptide Enhances Signaling of Depalmitoylated Hedgehog to the Patched Receptor

残留的 N 端肽增强去棕榈酰化 Hedgehog 向 Patched 受体的信号传导

Hedgehog is relayed through dynamic heparan sulfate interactions to shape its gradient

Hedgehog 通过动态硫酸乙酰肝素相互作用来形成其梯度

Drosophila hedgehog signaling range and robustness depend on direct and sustained heparan sulfate interactions

果蝇刺猬信号范围和稳健性取决于直接和持续的硫酸乙酰肝素相互作用

Conserved cholesterol-related activities of Dispatched 1 drive Sonic hedgehog shedding from the cell membrane

Dispatched 1 驱动 Sonic hedgehog 从细胞膜脱落的胆固醇相关活性

Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production

病变边缘的成熟少突胶质细胞限制脱髓鞘，并通过硫酸肝素的产生促进髓鞘修复

Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis

分泌性金属蛋白酶 ADAMTS9 和 ADAMTS20 在纤毛发生过程中对纤毛囊泡生长具有非典型作用

Soluble Heparin and Heparan Sulfate Glycosaminoglycans Interfere with Sonic Hedgehog Solubilization and Receptor Binding

可溶性肝素和硫酸肝素糖胺聚糖干扰 Sonic Hedgehog 溶解和受体结合

Proteolytic processing of palmitoylated Hedgehog peptides specifies the 3-4 intervein region of the Drosophila wing

棕榈酰化 Hedgehog 肽的蛋白水解加工指定了果蝇翅脉间 3-4 个区域

Disrupting Hedgehog Cardin-Weintraub sequence and positioning changes cellular differentiation and compartmentalization in vivo

破坏 Hedgehog Cardin-Weintraub 序列和定位会改变体内细胞的分化和区室化