日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Autoinhibition of dimeric NINJ1 prevents plasma membrane rupture

二聚体NINJ1的自身抑制可防止质膜破裂

Sergei Pourmal # ,Melissa E Truong # ,Matthew C Johnson # ,Ying Yang # ,Lijuan Zhou ,Kamela Alegre ,Irma B Stowe ,Shalini Gupta ,Phoebe A Chen ,Yingnan Zhang ,Alexis Rohou ,Kim Newton ,Nobuhiko Kayagaki ,Vishva M Dixit ,Ishan Deshpande

Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion

肠道致病菌可逃避ROCK驱动的上皮细胞挤出

Giovanni Luchetti,Marin V Miner,Rachael M Peterson,William P Scott,Praveen Krishnamoorthy,Eric M Kofoed,Angel G Jimenez,Hua Zhang,Man Wah Tan,Rohit Reja,Tommy K Cheung,Elizabeth Skippington,Yuxin Liang,Christopher M Rose,Nobuhiko Kayagaki,Kim Newton,Isabella Rauch,Vishva M Dixit

Author Correction: Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury

作者更正:使用 NINJ1 抗体抑制膜破裂可减少组织损伤

Kayagaki, Nobuhiko; Stowe, Irma B; Alegre, Kamela; Deshpande, Ishan; Wu, Shuang; Lin, Zhonghua; Kornfeld, Opher S; Lee, Bettina L; Zhang, Juan; Liu, John; Suto, Eric; Lee, Wyne P; Schneider, Kellen; Lin, WeiYu; Seshasayee, Dhaya; Bhangale, Tushar; Chalouni, Cecile; Johnson, Matthew C; Joshi, Prajakta; Mossemann, Jan; Zhao, Sarah; Ali, Danish; Goldenberg, Neil M; Sayed, Blayne A; Steinberg, Benjamin E; Newton, Kim; Webster, Joshua D; Kelly, Ryan L; Dixit, Vishva M

NINJ1 mediates plasma membrane rupture during lytic cell death

NINJ1 介导溶菌细胞死亡过程中的质膜破裂

Nobuhiko Kayagaki, Opher S Kornfeld, Bettina L Lee, Irma B Stowe, Karen O'Rourke, Qingling Li, Wendy Sandoval, Donghong Yan, Jing Kang, Min Xu, Juan Zhang, Wyne P Lee, Brent S McKenzie, Gözde Ulas, Jian Payandeh, Merone Roose-Girma, Zora Modrusan, Rohit Reja, Meredith Sagolla, Joshua D Webster, Vick

Selective activation of PFKL suppresses the phagocytic oxidative burst

PFKL 的选择性激活可抑制吞噬细胞的氧化爆发

Neri Amara, Madison P Cooper, Maria A Voronkova, Bradley A Webb, Eric M Lynch, Justin M Kollman, Taylur Ma, Kebing Yu, Zijuan Lai, Dewakar Sangaraju, Nobuhiko Kayagaki, Kim Newton, Matthew Bogyo, Steven T Staben, Vishva M Dixit

Shigella ubiquitin ligase IpaH7.8 targets gasdermin D for degradation to prevent pyroptosis and enable infection

志贺氏菌泛素连接酶IpaH7.8靶向gasdermin D进行降解,从而阻止细胞焦亡并促进感染。

Giovanni Luchetti,Justin L Roncaioli,Roberto A Chavez,Alexander F Schubert,Eric M Kofoed,Rohit Reja,Tommy K Cheung,Yuxin Liang,Joshua D Webster,Isabelle Lehoux,Elizabeth Skippington,Janina Reeder,Benjamin Haley,Man Wah Tan,Christopher M Rose,Kim Newton,Nobuhiko Kayagaki,Russell E Vance,Vishva M Dixit

Evolutionary loss of inflammasomes in the Carnivora and implications for the carriage of zoonotic infections

食肉目动物炎症小体的进化丧失及其对人畜共患感染的影响

Zsofi Digby, Panagiotis Tourlomousis, James Rooney, Joseph P Boyle, Betsaida Bibo-Verdugo, Robert J Pickering, Steven J Webster, Thomas P Monie, Lee J Hopkins, Nobuhiko Kayagaki, Guy S Salvesen, Soren Warming, Lucy Weinert, Clare E Bryant

MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition

MCC950/CRID3 可有效靶向野生型 NLRP3 的 NACHT 结构域,但不靶向疾病相关突变体以抑制炎症小体

Lieselotte Vande Walle, Irma B Stowe, Pavel Šácha, Bettina L Lee, Dieter Demon, Amelie Fossoul, Filip Van Hauwermeiren, Pedro H V Saavedra, Petr Šimon, Vladimír Šubrt, Libor Kostka, Craig E Stivala, Victoria C Pham, Steven T Staben, Sayumi Yamazoe, Jan Konvalinka, Nobuhiko Kayagaki, Mohamed Lamkanfi

Correction: MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition

更正:MCC950/CRID3 能有效靶向野生型 NLRP3 的 NACHT 结构域,但不能靶向与疾病相关的突变体,从而抑制炎症小体。

Walle, Lieselotte Vande; Stowe, Irma B; Šácha, Pavel; Lee, Bettina L; Demon, Dieter; Fossoul, Amelie; Van Hauwermeiren, Filip; Saavedra, Pedro H V; Šimon, Petr; Šubr, Vladimír; Kostka, Libor; Stivala, Craig E; Pham, Victoria C; Staben, Steven T; Yamazoe, Sayumi; Konvalinka, Jan; Kayagaki, Nobuhiko; Lamkanfi, Mohamed

Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death

病原体阻断TAK1可触发caspase-8依赖性的gasdermin D裂解和细胞死亡

Orning, Pontus; Weng, Dan; Starheim, Kristian; Ratner, Dmitry; Best, Zachary; Lee, Bettina; Brooks, Alexandria; Xia, Shiyu; Wu, Hao; Kelliher, Michelle A; Berger, Scott B; Gough, Peter J; Bertin, John; Proulx, Megan M; Goguen, Jon D; Kayagaki, Nobuhiko; Fitzgerald, Katherine A; Lien, Egil